Parenterally - intravenously (intravenously), drip. The injection rate is 60-80 cap / min.
Intravenous administration of the drug is recommended when sharply progressive and common forms destructive pulmonary tuberculosis, severe purulent-septic processes, if necessary to quickly create high concentrations of the drug in the blood and in the source of infection, in cases where the intake of the drug inside is difficult or poorly tolerated by patients. With intravenous administration, the daily dose for adults is 450 mg, in severe, fast-progressive forms - 600 mg, is administered in a single dose.The duration of intravenous administration depends on the tolerability of the drug and is 1 month or more (with a subsequent transition to oral administration). The total duration of admission for tuberculosis is determined by the effectiveness of treatment and can reach 1 year.
With infections of non-tuberculous etiology, the daily dose of Rifampicin-Ferein® is 600-900 mg (maximum is 1200 mg). The daily dose is divided into 2-3 injections. The duration of treatment is set individually,
depends on the effectiveness and can be 7-10 days. Intravenous administration should be discontinued as soon as possible for oral administration. Preparation of the solution for intravenous infusion: dissolve the lyophilizate (600 mg of rifampicin) in 10 ml of water, vigorously shake the vial to ensure complete dissolution of the contents of the vial. The resulting solution is mixed with 500 ml of a 5% dextrose solution. If a smaller dose of rifampicin is needed, the required amount of ml from a vial of dissolved preparation (10 ml = 600 mg of rifampicin, 5 ml to 300 mg of rifampicin, etc.) is taken and mixed with a 5% solution of dextrose. For the treatment of tuberculosis, at least one antituberculous agent is combined (isoniazid, pyrazinamide, ethambutol, streptomycin).Adults with a body weight of less than 50 kg - 450 mg / day; 50 kg and more - 600 mg / day. Children older than 2 months - 10-20 mg / kg / day; the maximum daily dose is 600 mg. With tuberculous meningitis, disseminated tuberculosis, spinal cord injury with neurological manifestations, with a combination of tuberculosis with HIV infection overall treatment duration - 9 months, the drug is used on a daily basis: the first 2 months in combination with isoniazid, pyrazinamide and ethambutol (or streptomycin), 7 months - in combination with isoniazid. In the case of pulmonary tuberculosis and detection of mycobacteria in sputum, apply the following scheme 3 (all of 6 months): The first 2 months - as defined above; 4 months - daily, in combination with isoniazid.
The first 2 months are as above; 4 months - in combination with isoniazid, 2-3 times during each week. Throughout the course - the reception in combination with isoniazid, pyrazinamide and ethambutol (or streptomycin) 3 times during each week. In those cases when antituberculous drugs
apply 2-3 times a week (as well as in case of exacerbation of the disease or inefficiency of therapy), their reception must be carried out under the supervision of medical personnel.To treat multibacillary types of leprosy (lepromatous, borderline, lepromatous and borderline) adults - 600 mg once a month in combination with other antimicrobial drugs, active in relation to Mycobacterium leprae; children older than 2 months - 10 mg / kg once a month in combination with other antimicrobial drugs active against Mycobacterium leprae. The minimum duration of treatment is 2 years. For the treatment of multibacillary types of leprosy (tuberculoid and border tuberculosis) adults - 600 mg once a month, in combination with other antimicrobials, active against Mycobacterium leprae; children older than 2 months - 10 mg / kg once a month, in combination with other antimicrobials, active against Mycobacterium leprae. Duration of treatment - 6 months.
For the treatment of infectious diseases caused by Sensitive microorganisms are prescribed in combination with other antimicrobial agents.
The daily dose for adults is 600-1200 mg; for children older than 2 months - 10-20 mg / kg. Multiplicity of admission - 2 times a day.
For the treatment of brucellosis - 900 mg / day once in combination with doxycycline; mean the duration of treatment is 45 days.For the prevention of meningococcal meningitis - 2 times a day every 12 hours for 2 days. Single doses for adults - 600 mg; for children older than 2 months - 10 mg / kg.
Patients with abnormalities excretory function of the kidneys and
preserved liver function correction dose is required only in the event that,
when it exceeds 600 mg / day.