Inside, on an empty stomach, 30 minutes before meals.
For the treatment of tuberculosis, at least one antituberculous drug is combined (isoniazid, pyrazinamide, ethambutol, streptomycin). Adults with a body weight of less than 50 kg - 450 mg / day, 50 kg or more - 600 mg / day.
Children older than 3 years - 10-20 mg / kg per day, the maximum daily dose - 600 mg. With tuberculous meningitis,disseminated tuberculosis, spinal cord injury with neurological manifestations, with the combination of tuberculosis with HIV infection, the total duration of treatment is 9 months: the drug is used daily - the first 2 months, in combination with isoniazid, pyrazinamide and ethambutol (ipi streptomycin), 7 months in combination with isoniazid.
In the case of pulmonary tuberculosis and detection of mycobacteria in sputum, the following 3 regimens (all of 6 months) are used:
1. The first 2 months are as above; 4 months - daily, in combination with isoniazid.
2. The first 2 months are as above; 4 months - in combination with isoniazid, 2-3 times during each week.
3. Throughout the course - the reception in combination with isoniazid, pyrazinamide and ethambutol (or streptomycin) 3 times during each week. In cases where anti-TB drugs are used 2-3 times a week (as well as in case of exacerbation of the disease or inefficiency of therapy), they should be taken under the supervision of medical personnel.
To treat multibacillary types of leprosy (lepromatous, borderline-lepromatous and borderline) adults - 600 mg once a month in combinationwith dapsone (100 mg once a day) and clofazimine (50 mg once a day + 300 mg once every 1 month); children older than 3 years - 10 mg / kg once a month in combination with dapsone (1-2 mg / kg / day) and clofazimine (50 mg every other day + 200 mg once a month).
The minimum duration of treatment is 2 years.
To treat pausibacillary types of leprosy (tuberculoid and border tuberculoid): adults - 600 mg once a month, in combination with dapsone - 100 mg (1 - 2 mg / kg) once a day; children older than 3 years - 10 mg / kg once a month, in combination with dapsone - 1 - 2 mg / kg / day. Duration of treatment - 6 months.
To treat infectious diseases caused by sensitive microorganisms, it is prescribed in combination with other antimicrobial agents.
Daily intake for adults - 0.6 - 1.2 g; for children older than 3 years - 10-20 mg / kg. Multiplicity of admission - 2 times a day.
For treatment of brucellosis - 900 mg / day once, in the morning on an empty stomach, in combination with doxycycline; the average duration of treatment is 45 days.
For the prevention of meningococcal meningitis - 2 times a day every 12 hours for 2 days. Single doses for adults - 600 mg; for children over 3 years old -10 mg / kg.
Patients with impaired renal excretory function and preserved liver function need to adjust the dose only when it exceeds 600 mg / day.
Precautions for use
Treatment with rifampicin should be done under close medical supervision. During treatment the skin, mucus, sweat, feces, lacrimal fluid, urine becomes orange-red color. Can persistently stain soft contact lenses.
With non-tuberculosis diseases, it is prescribed only if other antibiotics are ineffective (rapid development of resistance).
To prevent the development of resistance, microorganisms must be used in combination with other antimicrobial agents.
In the case of the development of the flu-like syndrome, not complicated by thrombocytopenia, hemolytic anemia, bronchospasm, dyspnea, shock and renal insufficiency, patients receiving the medication according to the intermittent schedule should consider the possibility of switching to a daily dose. In these cases, the dose is increased slowly: on the first day, 75-150 mg, and the desired therapeutic dose is reached in 3-4 days. In the event that the above serious complications are noted, rifampicin cancel. It is necessary to monitor kidney function; an additional prescription of glucocorticosteroids is possible.
Women of childbearing age during treatment should use reliable methods of contraception (oral hormonal contraceptives and additional non-hormonal methods of contraception).
In the preventive use of meningococcus bacilli carriers, close medical supervision of patients is necessary in order to timely identify the symptoms of the disease in the event of resistance to rifampicin. With prolonged use, systematic monitoring of the peripheral blood pattern and liver function is necessary. During the treatment period, it is impossible to apply microbiological methods for determining the concentration of folic acid and vitamin B12 in the blood serum, Alcohol and taking the drug are incompatible.