Inside, on an empty stomach, 30 minutes before meals. For the treatment of tuberculosis, at least one antituberculous agent is combined (
isoniazid,
pyrazinamide,
ethambutol,
streptomycin). Adults with a body weight of less than 50 kg - 450 mg / day; 50 kg and more - 600 mg / day. Children and newborns - 10-20 mg / kg per day; the maximum daily dose is 600 mg.
With tuberculous meningitis, disseminated tuberculosis, spinal cord injury with neurological manifestations,with the combination of tuberculosis with HIV, the total duration of treatment is 9 months, the drug is used daily, the first 2 months in combination with isoniazid, pyrazinamide and ethambutol (or streptomycin), 7 months - in combination with isoniazid.
In the case of pulmonary tuberculosis and detection of mycobacteria in sputum, the following 3 regimens are used (all with a duration of 6 months):
1. The first 2 months - as indicated above; 4 months - daily, in combination with isoniazid.
2. The first 2 months - as indicated above; 4 months - in combination with isoniazid, 2-3 times during each week.
3. Throughout the course - the reception in combination with isoniazid, pyrazinamide and ethambutol (or streptomycin) 3 times during each week. In cases where anti-TB drugs are used 2-3 times a week (as well as in case of exacerbation of the disease or inefficiency of therapy), they should be taken under the supervision of medical personnel.
For treatment of multibacillary types of leprosy (lepromatous, borderline, lepromatous and borderline) adults - 600 mg once a month in combination with dapsone (100 mg once a day) and clofazimine (50 mg once a day + 300 mg once a month ); Children 10 mg / kg once a month in combination with dapsone (1-2 mg / kg / day) and clofazimine (50 mg every other day + 200 mg once a month).The minimum duration of treatment is 2 years.
To treat pausibacillary types of leprosy (tuberculoid and border tuberculoid) adults - 600 mg once a month, in combination with dapsone - 100 mg (1-2 mg / kg) once a day; Children - 10 mg / kg once a month, in combination with dapsone - 1-2 mg / kg / day. Duration of treatment - 6 months.
For the treatment of infectious diseases caused by sensitive microorganisms, it is prescribed in combination with other antimicrobial agents. The daily intake for adults is -0.6-1.2 g; for children and newborns - 10-20 mg / kg. Multiplicity of admission - 2 times a day. For treatment of brucellosis - 900 mg / day once, in the morning on an empty stomach, in combination with doxycycline; the average duration of treatment is 45 days.
For the prevention of meningococcal meningitis - 2 times a day every 12 hours for 2 days. Single doses for adults - 600 mg; for children -10 mg / kg; for newborns - 5 mg / kg. Patients with violations of the excretory function of the kidneys and preserved liver function correction of the dose is required only when it exceeds 600 mg / day.