Vikasol - instructions for use, dose, side effects, contraindications

Excipients: sucrose (sugar) - 60.9 mg, potato starch-20.4 mg, sodium disulfite (sodium metabisulphite) 1.0 mg, stearic acid 0.9 mg, talc (talcum powder) -1.6 mg, silicone emulsion (emulsion of CE 10-12) - 0.2 mg.

Description:Tablets are white or almost white in color, flat-cylindrical with a bevel.

Pharmacotherapeutic group:Vitamin

ATX: & nbsp

B.02.B.A.02 Menadion

B.02.B.A Vitamin K

Pharmacodynamics:Synthetic water-soluble analogue of vitamin K, promotes the synthesis of prothrombin and proconvertin,increases the coagulability of blood by increasing the synthesis of II. VII. IX. X. Coagulation factors.

Has a hemostatic effect (with a deficiency of vitamin K there is increased bleeding).

In the blood, prothrombin (factor II) in the presence of thromboplastin and calcium, with the participation of proconvertin (factor VII). factors IX (the Crystal factor), X (the Stewart-Plower factor) goes into thrombin, under the influence of which fibrinogen turns into fibrin, which forms the basis of a blood clot (thrombus).

Substrate stimulates K-vitamin reductase, which activates vitamin K and ensures its participation in the hepatic synthesis of K-vitamin-dependent plasma factors of hemostasis.

The onset of the effect is 7-12 hours after ingestion.

Pharmacokinetics:After oral administration, it is easily and quickly absorbed. In small amounts, it accumulates in the tissues. After passing a cycle of metabolic activation, it is oxidized to the diol form in the liver. It is excreted by the kidneys (up to 70%) and with bile almost exclusively in the form of metabolites. High concentrations of vitamin K in the feces are due to its synthesis by intestinal microflora.

Indications:Hemorrhagic syndrome associated with hypoprothrombinemia: hypovitaminosis K (including with obstructive jaundice, hepatitis, cirrhosis, prolonged diarrhea).

Bleeding after wounds, injuries and surgical interventions: as a part of complex therapy of dysfunctional uterine bleeding, menorrhagia. Hypoprothrombinemia due to a decrease in the content of factors II. VII. IX. X. on the background of taking some medicines (coumarin and indanedione derivatives, salicylates, some antibiotics).

Contraindications:Hypersensitivity to the components of the drug. Increased blood clotting, thromboembolism, hemolytic disease of the newborn. Deficiency of sugar and / or isomaltase, intolerance to fructose, glucose-galactose malabsorption.

Children under 3 years.

Carefully:Deficiency of glucose-6-phosphate dehydrogenase, hepatic insufficiency, pregnancy, lactation period, diabetes mellitus.

With obstructive jaundice, the injectable form of the drug should be preferred.

Pregnancy and lactation:The use of the drug is possible only if the intended benefit to the mother exceeds the potential risk to the fetus and the baby.

Preventive prescription of vitamin K in the III trimester of pregnancy is ineffective due to low permeability for the placenta.

Dosing and Administration:Inside.

The drug is prescribed for 3-4 days, after a four-day break, the course is repeated. The daily dose can be divided into 2-3 doses.

The maximum single dose for adults is 30 mg, the maximum daily dose for adults is 60 mg.

When surgical interventions with possible severe parenchymal hemorrhage are prescribed within 2-3 days before the operation.

In pediatrics: from 3 to 5 years - 7.5 mg / day, from 5 to 14 years - 15 mg / day, over 14 years -30 mg / day.

Side effects:Allergic reactions: hyperemia of the face, skin rash (including erythematous, urticaria), skin itching, bronchospasm.

On the part of the blood system: hemolytic anemia, hemolysis in children with congenital deficiency of glucose-6-phosphate dehydrogenase.

Other: hyperbilirubinemia, jaundice, rarely - dizziness, transient lowering of arterial pressure, "profuse" sweat, tachycardia, "weak" filling of the pulse, change in taste sensations.

Overdose:When an overdose occurs hypervitaminosis K, manifested by hyperprotrombinemia, hyperbilirubinemia, rarely in children may be seizures.

Interaction:Reduces or blocks the anticoagulant effect of neodicumarin and phenidine.

Does not affect the anticoagulant activity of heparin.

Antacids reduce absorption due to precipitation of bile salts in the initial part of the small intestine.

Simultaneous administration with antibiotics of a wide spectrum of action, minidin, quinine, salicylates in high doses, antibacterial sulfonamides requires an increase in the dose of vitamin K.

Kolestyramine, colestipol, mineral oils, sucralfate, dactinomycin I reduce the absorption of vitamin K, which requires an increase in its dose.

Special instructions:In hemophilia, Willebrand disease and Verlhof disease, the drug is ineffective.

In diseases that lead to a violation of the outflow of bile, parenteral administration is recommended.

Effect on the ability to drive transp. cf. and fur:During the period of application of the drug, care should be taken when driving vehicles and various mechanisms, as well as in other potentially hazardous activities requiring increased attention and speed of mental and motor reactions.

Form release / dosage:Pills.

Packaging:For 10 or 20 pieces in a planar cell package.For 1, 2 or 3 contour mesh packages in a pack of cardboard along with instructions for use.

Storage conditions:Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life:3 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LS-002164

Date of registration:23.07.2010 / 28.02.2014

Expiration Date:Unlimited

The owner of the registration certificate:PHARMSTANDART-FORESTRY, OJSC PHARMSTANDART-FORESTRY, OJSC Russia

Manufacturer: & nbsp

PHARMSTANDART-FORESTRY, OJSC Russia

Information update date: & nbsp14.02.2017

Illustrated instructions

Instructions

Vikasol (Vikasol)