Vikasol-Vial (Vikasol-Vial)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceMenadione sodium bisulfiteMenadione sodium bisulfite
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    • Dosage form: & nbspsolution for intramuscular injection
    Composition:1 ml of the solution contains:

    active substance - menadione sodium bisulfite (Vikasol) in terms of sodium hydrate 10 mg:

    Excipients - sodium hydrosulfite, sodium disulphite, acetic acid 36-37%. water for injections.

    Description:Transparent colorless or light yellow liquid.
    Pharmacotherapeutic group:Vitamin K analogue synthetic
    ATX: & nbsp

    B.02.B.A.02   Menadion

    B.02.B.A   Vitamin K

    Pharmacodynamics:Vitamins of group K are included in the composition of enzymes involved in the synthesis of prothrombin (factor II), factors VII,IX and X in the liver, necessary for the formation of active thromboplastin and thrombin, contribute to the normalization of the process of blood coagulation. Has a hemostatic effect (with a deficiency of vitamin K there is increased bleeding).

    The effect manifests itself 8-24 hours after intramuscular injection.

    Pharmacokinetics:After intramuscular injection, it is absorbed easily and quickly. In small amounts, it accumulates in the tissues. After passing the cycle of metabolic activation, it is oxidized to the diol form in the liver. It is excreted by the kidneys and with bile almost exclusively in the form of metabolites. High concentrations of vitamin K in the feces are due to its synthesis by intestinal microflora.
    Indications:Hemorrhagic syndrome associated with hypoprothrombinemia; hypovitaminosis K (including with obstructive jaundice, hepatitis, liver cirrhosis, prolonged diarrhea); bleeding after wounds, injuries and surgical interventions; in the complex therapy of dysfunctional uterine bleeding, menorrhagia. Treatment and prevention of hemorrhagic disease of newborns. Overdose of antagonists of vitamin K (fenindion, acenocoumarol etc.)
    Contraindications:Hypersensitivity to the components of the drug. Increased blood clotting, thromboembolism. Hemolytic disease of newborns.
    Carefully:Deficiency of glucose-6-phosphate dehydrogenase, hepatic insufficiency, pregnancy.
    Pregnancy and lactation:Data on the adverse effects of the drug on the fetus and infants who are breastfed are not available. Therefore, when deciding on the possibility of using a drug, it is necessary to correlate the benefits to the mother and the risk to the fetus or baby.
    Dosing and Administration:The drug is administered intramuscularly.

    For adults, a single dose is 10-15 mg, the maximum single dose is 30 mg, the maximum daily dose is 60 mg.

    In pediatrics:

    newborn

    up to 4 mg / day

    up to 1 year

    2-5 mg / day

    1 -2 years

    6 mg / day

    3-4 years

    8 mg / day

    5-9 years

    10 mg / day

    10-14 years old

    15 mg / day

    From the age of 15 the drug is prescribed the same way. as well as adult patients. Duration of treatment is 3-4 days. after a four-day break, again 3-4 days. The daily dose can be divided into 2-3 doses. When surgical interventions with possible severe parenchymal hemorrhage are prescribed within 2-3 days before the operation.

    Side effects:Allergic reactions: hyperemia of the face, skin rash (incl.erythematous, urticaria), itching of the skin, bronchospasm.

    On the part of the blood system: hemolytic anemia, hemolysis in newborn children with congenital deficiency of glucose-6-phosphate dehydrogenase.

    Local reactions: pain and swelling at the injection site, skin lesions in the form of spots with repeated injections in the same place.

    Other: Hyperbilirubinemia (jaundice), especially in premature infants. Rarely - dizziness, transient lowering of arterial pressure, profuse sweat, tachycardia, "weak" filling of the pulse, a change in taste sensations.

    Overdose:If overdose occurs hypervitaminosis K manifested giperprotrombinemiey, hyperbilirubinemia, rarely, children may have seizures.

    Treatment is symptomatic.

    Interaction:Reduces or blocks the anticoagulant effect of phenyldione, acenocoumarol.

    Does not affect the anticoagulant activity of heparin.

    Simultaneous appointment with antibiotics of a wide spectrum of action, quinidine, quinine, salicylates in high doses, sulfonilamide preparations requires an increase in the dose of vitamin K.

    Special instructions:In hemophilia, Willebrand disease and Verlhof disease, the drug is ineffective.If deficient, glucose-6-phosphate dehydrogenase can cause hemolysis.
    Form release / dosage:Solution for intramuscular administration 10 mg / ml.
    Packaging:1 ml per ampoule of light-protective neutral glass with a broken point. 10 ampoules per contour cell package. One contour mesh package together with the instruction for use is placed in a cardboard box.
    Storage conditions:List B. Store in a dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:3 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-001144/10
    Date of registration:18.02.2010
    Expiration Date:Unlimited
    The owner of the registration certificate:VIAL, LLC VIAL, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspVIAL, LLCVIAL, LLC
    Information update date: & nbsp14.02.2017
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