Vikasol - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Vitamins of group K are included in the composition of enzymes,participating in the synthesis of prothrombin (factor II), factors VII, IX and X in the liver, necessary for the formation of active thromboplastin and thrombin, contribute to the normalization of the process of blood coagulation. Has a hemostatic effect (with a deficiency of vitamin K there is increased bleeding).

The effect is manifested 12-18 hours after intramuscular injection.

Pharmacokinetics:After intramuscular injection, it is absorbed easily and quickly. In small amounts, it accumulates in the tissues. After passing the cycle of metabolic activation, it is oxidized to the diol form in the liver. It is excreted by the kidneys and with bile almost exclusively in the form of metabolites. High concentrations of vitamin K in the feces are due to its synthesis by intestinal microflora.

Indications:Hemorrhagic syndrome associated with hypoprothrombinemia; hypovitaminosis K (including with obstructive jaundice, hepatitis, liver cirrhosis, prolonged diarrhea); bleeding after wounds, injuries and surgical interventions; in the complex therapy of dysfunctional uterine bleeding, menorrhagia. Treatment and prevention of hemorrhagic disease of newborns. Overdose of drugs - antagonists of vitamin K (fenindion, ethyl biscumacetate, etc.).

Contraindications:Hypersensitivity to the components of the drug. Increased blood clotting, thromboembolism. Hemolytic disease of newborns.

Carefully:Deficiency of glucose-6-phosphate dehydrogenase, hepatic insufficiency, pregnancy.

Pregnancy and lactation:Data on the adverse effects of the drug on the fetus and infants who are breastfed are not available. Therefore, when deciding on the possibility of using a drug, it is necessary to correlate the benefits to the mother and the risk to the fetus or baby.

Dosing and Administration:The drug is administered intramuscularly.

For adults, a single dose is 10-15 mg, the maximum single dose is 30 mg, the maximum daily dose is 60 mg.

In pediatrics:

newborn	up to 4 mg / day
up to 1 year	2-5 mg / day
1-2 years	6 mg / day
3-4 years	8 mg / day
5-9 years	10 mg / day
10-14 years old	15 mg / day

From the age of 15, the drug is prescribed in the same way as adult patients.

Duration of treatment 3-4 days, after a four-day break, again 3-4 days. The daily dose can be divided into 2-3 doses.In surgical interventions with possible severe parenchymal hemorrhage, a 2-3-day operation is prescribed before surgery.

Side effects:Allergic reactions: hyperemia of the face, skin rash (including erythematous, urticaria), skin itching, bronchospasm.

On the part of the blood system: hemolytic anemia, hemolysis in newborn children with congenital deficiency of glucose-6-phosphate dehydrogenase.

Local reactions: pain and swelling at the injection site, skin lesions in the form of spots with repeated injections in the same place.

Other: Hyperbilirubinemia (jaundice), especially in premature infants. Rarely - dizziness, transient lowering of arterial pressure, profuse sweat, tachycardia, "weak" filling of the pulse, a change in taste sensations.

Overdose:When an overdose occurs hypervitaminosis K, manifested by hyperprotrombinemia, hyperbilirubinemia, rarely in children may be seizures.

Treatment is symptomatic.

Interaction:Reduces or blocks the anticoagulant effect of phenyldione and ethyl biscumacetate. Does not affect the anticoagulant activity of heparin.

Simultaneous administration with antibiotics of a wide spectrum of action, quinidine, quinine,salicylates in high doses, sulfanilamide preparations require an increase in the dose of vitamin K.

Special instructions:With hemophilia, Willebrand disease and Verlhof disease, the drug is not effective. If deficient, glucose-6-phosphate dehydrogenase can cause hemolysis.

Form release / dosage:Solution for intramuscular injection 10 mg / ml.

Packaging:1 ml per ampoule of neutral glass. 5 ampoules are placed in a contour mesh box made of a polyvinylchloride film and aluminum foil or without foil. 1 or 2 contour mesh packages with a scarifier ampoule ceramic or knife for opening ampoules and instructions for use are placed in a pack of cardboard. When using ampoules with a fracture ring or break point, the knife or scarifier is not inserted.

Storage conditions:Store in a dark place at a temperature of no higher than 25 ° C. Freezing is not allowed. Keep out of the reach of children.

Shelf life:3 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-004802/10

Date of registration:27.05.2010 / 21.03.2016

Expiration Date:Unlimited

The owner of the registration certificate:BINNOFARM, CJSC BINNOFARM, CJSC Russia

Manufacturer: & nbsp

BINNOFARM, CJSC Russia

Information update date: & nbsp14.02.2017

Illustrated instructions

Instructions

Vikasol (Vikasol)