Active substanceMenadione sodium bisulfiteMenadione sodium bisulfite
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  • Dosage form: & nbsppills
    Composition:For one tablet:

    Active substances: menadione sodium bisulfite - 15 mg.

    Excipients: lactose monohydrate - 69.7 mg, starch

    potato - 14.1 mg, calcium stearate -1.0 mg, sodium metabisulphite - 0.2 mg.

    Description:Tablets are white or almost white, round, flat-cylindrical, with a bevel.
    Pharmacotherapeutic group:Vitamin
    ATX: & nbsp

    B.02.B.A.02   Menadion

    B.02.B.A   Vitamin K

    Pharmacodynamics:Has a hemostatic effect.

    The drug group vitamin K, Increases blood clotting by increasing the production of liver factors II, VII, IX, X.The effect is manifested 12-18 hours after the / m administration. In the blood, prothrombin (factor II) in the presence of thromboplastin and calcium ions, with the participation of Procon-vertine (factor VII) factors IX and X enters thrombin, under the influence of which fibrinogen turns into fibrin, which forms the basis of a blood clot (thrombus). With a deficiency of vitamin K, the synthetic homologue of which is menadione, there is increased bleeding. Substrate K-vitaminreduktazu stimulate, the activation of vitamin K and ensures its participation in the hepatic synthesis of K-vitaminozavisimyh plasma hemostasis factors. After the / m introduction is easily and quickly absorbed.

    Pharmacokinetics:After the / m introduction is easily and quickly absorbed. After a cycle of metabolic activation, it is oxidized to a diol form. It is excreted by the kidneys.
    Indications:Bleeding (hemorrhage) against hypoprothrombinemia: obstructive jaundice, hepatitis, parenchymal and capillary bleeding at wounds, surgery, and radiation ulcer disease: hemorrhoids, uterine, lung and long epistaxis: hemorrhagic phenomena preterm: overdose neodikumarina et al.indirect anticoagulants.
    Contraindications:Hypersensitivity to the components of the drug; increased blood clotting, thromboembolism; deficiency of lactase, lactose intolerance; hemolytic disease of newborns.
    Carefully:Deficiency of glucose-6-phosphate dehydrogenase, kidney failure.
    Dosing and Administration:Inside, adults - 15-30 mg / day, children - 2-15 mg / day, depending on age.
    Side effects:Allergic reactions: hypersensitivity to one of the components of the drug, facial hyperemia, skin rash (including erythematous), urticaria, skin itching, bronchospasm.

    On the part of the blood system: hemolytic anemia, hemolysis in newborn children with congenital deficiency of glucose-6-phosphate dehydrogenase.

    Other: hyperbilirubinemia, jaundice (including kernicterus in infants), dizziness, a transient decrease in blood pressure, profuse sweating, tachycardia, "weak" filling rate, change in taste.

    Interaction:Weakens the effects of indirect anticoagulants.
    Form release / dosage:Tablets 15 mg.
    Packaging:For 30 tablets in a jar of polymer materials.

    For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

    On 3 contour cellular packs or 1 can of polymeric materials together with the instruction on medical application place in a pack from a cardboard.

    Storage conditions:Store in a dry, dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:3 years. After expiration date the drug should not be used.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-004919/08
    Date of registration:25.06.2008 / 01.07.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:AVEKSIMA, JSC AVEKSIMA, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp14.02.2017
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