Vikasol - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Synthetic water-soluble analogue of vitamin K, promotes the synthesis of prothrombin and proconvertin, increases blood coagulability by enhancing the synthesis of II, VII, IX, X coagulation factors. Has a hemostatic effect (with a deficiency of vitamin K there is increased bleeding). In the blood, prothrombin (factor II) in the presence of thromboplastin and calcium ions, with the participation of proconvertin (factor VII), coagulation factors IX (the factor of Christ), X (the Stewart-Plower factor) thrombin, under the influence of which fibrinogen turns into fibrin, which forms the basis of a blood clot (thrombus). Substrate stimulates vitamin K-epoxy-reductase, which activates vitamin K and ensures its participation in hepatic synthesis of K-vitamin-dependent plasma factors of hemostasis.

Pharmacokinetics:After oral administration, it is easily and quickly absorbed. In small amounts, it accumulates in the tissues. After passing a cycle of metabolic activation, it is oxidized to the diol form in the liver. It is excreted by the kidneys and with bile almost exclusively in the form of metabolites. High concentrations of vitamin K in the feces are due to its synthesis by intestinal microflora.

Indications:Hemorrhagic syndrome associated with hypoprothrombinemia; hypovitaminosis K (including with obstructive jaundice, hepatitis, liver cirrhosis, prolonged diarrhea); bleeding after wounds, injuries and surgical interventions; in the complex therapy of dysfunctional uterine bleeding, menorrhagia. Overdose of preparations-antagonists of vitamin K (ethyl biscumacetate, fenindione, etc.).

Contraindications:Hypersensitivity, hypercoagulability, thromboembolism, sugarase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, hemolytic disease of newborns, children under 3 years.

Carefully:Deficiency of glucose-6-phosphate dehydrogenase, hepatic insufficiency.

Pregnancy and lactation:It is used strictly according to the indications in the last months of pregnancy (to eliminate bleeding from the mother) under the supervision of the attending physician.

Dosing and Administration:Inside. Assign within 3-4 days, after a four-day break, again 3-4 days. The daily dose can be divided into 2-3 doses. When surgical interventions with possible severe parenchymal hemorrhage are prescribed within 2-3 days before the operation.

The maximum single dose for adults is 15-30 mg, the maximum daily dose to -7 for adults - 60 mg.

In pediatrics: 3-4 years - 8 mg / day, 5-9 years -10 mg / day, 10-14 years - 15 mg / day.

Side effects:Allergic reactions: hyperemia of the face, skin rash (including erythematous, urticaria), skin itching, bronchospasm.

On the part of the blood system: hemolytic anemia, hemolysis in newborn infants with congenital deficiency of glucose-6-dehydrogenase.

Other: hyperbilirubinemia, jaundice (including kernicterus in infants), dizziness, a transient decrease in blood pressure, profuse sweating, tachycardia, "weak" filling rate, change in taste.

Overdose:Symptoms: If overdose occurs hypervitaminosis K manifested giperprotrombinemiey, hyperbilirubinemia, rarely, children may have seizures.

Treatment: symptomatic.

Interaction:It reduces or blocks the anticoagulant effect of indirect anticoagulants - etilbiskumatsetata and phenindione. Does not affect the anticoagulant activity of heparin. Antacids reduce absorption due to precipitation of bile salts in the initial part of the small intestine.Simultaneous use with broad-spectrum antibiotics, quinidine, quinine, salicylates in high doses, sulfonamides requires an increase in the dose of vitamin K. Kolestyramine, colestipol, mineral oils, sucralfate, dactinomycin reduce the absorption of vitamin K, which requires an increase in its dose. Simultaneous use with drugs that cause hemolysis increases the risk of side effects.

Special instructions:In diseases that lead to a violation of outflow of bile, it is recommended to use another dosage form - injection solution. In hemophilia and von Willebrand disease, the use of the drug is not effective. The drug does not normalize the function of pathologically altered platelets. Preventive prescription of vitamin K in the III trimester of pregnancy is ineffective due to low permeability for the placenta.

Form release / dosage:Tablets 15 mg.

Packaging:10 tablets in a contour mesh box made of a polyvinylchloride film and aluminum foil.

30 tablets in a can of orange glass of the BTS type, sealed with a lid of a stretchable with sealing element or in a can of polymer type BP.

Each bank or 1, 2, 3 contoured cells with instructions for use are placed in a pack of cardboard.

Storage conditions:In dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LS-001664

Date of registration:29.07.2011

Expiration Date:Unlimited

The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia

Manufacturer: & nbsp

BIOSINTEZ, PAO Russia

Information update date: & nbsp14.02.2017

Illustrated instructions

Instructions

Vikasol (Vikasol)