Menadione sodium bisulfite - instructions for use, dose, side effects, contraindications

Increases coagulability of the blood, stimulating the production of factors II, VII, IX, X in the liver. With a deficiency of vitamin K, the synthetic homologue of which is menadione, there is increased bleeding.

Pharmacokinetics:

After intramuscular injection or ingestion, the drug is absorbed easily and quickly, the effect manifests itself after 12-18 hours. In small amounts, it accumulates in the tissues. After passing a cycle of metabolic activation, it is oxidized to the diol form in the liver. Elimination of the kidneys and feces solely in the form of metabolites.High concentrations of vitamin K in the feces are due to its synthesis by intestinal microflora.

Indications:

Increased bleeding against hypoprothrombinemia: obstructive jaundice, hepatitis.

Parenchymal and capillary bleeding in wounds.

Surgical operations.

Ulcer and radiation sickness.

Hemorrhoidal, uterine, pulmonary and prolonged nasal bleeding.

Hemorrhagic phenomena in prematurity.

Overdose of neodikumarina and other indirect anticoagulants.

ICD-10

III.D65-D69.D67 Hereditary deficiency of factor IX

III.D65-D69.D68.9 Disorder of coagulation, unspecified

IX.I70-I79.I78 Diseases of capillaries

XI.K70-K77.K73 Chronic hepatitis, not elsewhere classified

XI.K90-K93.K92.2 Gastrointestinal bleeding, unspecified

XIV.N80-N98.N93 Other abnormal bleeding from the uterus and vagina

XVIII.R00-R09.R04.0 Nose bleed

XVIII.R00-R09.R04.8 Bleeding from other parts of the respiratory tract

XVIII.R50-R69.R58 Bleeding, not elsewhere classified

XIX.T80-T88.T81.0 Bleeding and hematoma complicating the procedure, not elsewhere classified

Contraindications:

Individual intolerance.

Hypercoagulation.

Thromboembolism.

Hemolytic disease of newborns.

Carefully:

With a deficiency of glucose-6-phosphate dehydrogenase, liver failure.

Pregnancy and lactation:

The category of FDA recommendations is not defined. Application during pregnancy and during lactation is contraindicated.

Dosing and Administration:

Intramuscularly Enter 0.01-0.015 g once a day for 3-4 consecutive days. Repeat the course takes 4 days.

In surgical interventions with the expected high blood loss, the drug is prescribed for 2-3 days before the operation. Higher doses (intramuscularly): single - 0.015 g, daily - 0.03 g.

Inside, adults - 15-30 mg each day, children - 2-15 mg in day, depending on the age.

Side effects:

Blood: hemolytic anemia, hyperbilirubinemia.

Jaundice, especially in prematurity.

Hemolysis in newborns with congenital deficiency of glucose-6-phosphate dehydrogenase.

Allergic reactions.

Overdose:

Hypervitaminosis K is manifested by hyperprothrombinemia, hemolytic anemia, and convulsions are possible in children. Treatment with anticoagulants, drug withdrawal.

Interaction:

Weakens the effects of indirect anticoagulants.

Antacid preparations - a decrease in the absorption of sodium menadione bisulfite due to precipitation of bile salts in the initial section of the small intestine.

Dactinomycin, colestramine, colestipol, mineral oils, sucralfate - Reduction of absorption of sodium menadione bisulphite, which requires an increase in its dose.

Simultaneous administration with broad-spectrum antibiotics, quinidine, quinine, salicylates in high doses, antibacterial sulfonamides requires an increase in the dose of sodium menadione bisulphite (vitamin K).

Means that can cause hemolytic anemia - an increased risk of the latter.

Special instructions:

In diseases that lead to a violation of the outflow of bile, parenteral administration is recommended. With hemophilia and Verlhof's disease is ineffective.

Instructions

Menadione sodium bisulfite (Menadioni natrii bisulfis)