Xantinol nicotinate - instructions for use, dose, side effects, contraindications

Xanthinal nicotinate combines the properties of drugs of the theophylline and nicotinic acid group: it has anti-aggregative effect, expands peripheral vessels, improves collateral circulation.Blocking adenosine receptors and phosphodiesterase, increases the content of cyclic adenosine monophosphate in the cell, substrate stimulates the synthesis of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Improves microcirculation, oxygenation and nutrition of tissues, with prolonged use has antiatherosclerotic effect, activates the processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, enhances the activity of lipoprotein lipase, reduces the viscosity of blood, reduces the aggregation of platelets.

Reducing the overall peripheral vascular resistance, contributes to an increase in the minute volume of blood and increased cerebral circulation, reduces the severity of cerebral hypoxia.

Indications:

As part of complex therapy:

Atherosclerosis limbs, Raynaud's disease, endarteritis obliterans, diabetic angiopathy, acute thrombophlebitis (superficial and deep veins), leg sores, cerebrovascular insufficiency, cerebral atherosclerosis, stroke, coronary atherosclerosis, hypercholesterolemia, hypertriglyceridemia.

Contraindications:

Chronic heart failure, acute bleeding, acute myocardial infarction, mitral stenosis, peptic ulcer and duodenal ulcer (in the phase of exacerbation), arterial hypotension, pregnancy, acute renal failure, glaucoma; children under 3 years.

Pregnancy and lactation:

In the second and third trimester of pregnancy and during lactation, the use of the drug is permissible only in the presence of absolute indications and careful observation of the doctor.

Dosing and Administration:

Intravenous (jet or drip), intramuscularly.

The degree of severity of the disease, the condition of the patient and the route of administration of the drug are evaluated by a doctor.

With intramuscular injection - 2-6 ml of 15% solution daily for 2-3 weeks.

With intravenous jet injection - 2 ml 15 % solution 1-2 times a day for 5-10 days (the patient should be in a horizontal position).

When intravenous drip introduction - at a speed of 40-50 drops per minute, diluting 10 ml of 15% solution in 200-500 ml of 5% dextrose solution or in 200 ml of 0.9% sodium chloride solution.

Side effects:

Feeling of heat, tingling and redness of the skin of the upper body, especially the neck and head.These symptoms usually disappear after 10-20 minutes, do not require special treatment and discontinuation of therapy with this drug. Reduced blood pressure, weakness, dizziness, nausea, diarrhea, decreased appetite, gastralgia. With long-term administration in high doses, the drug causes a change in glucose tolerance, an increase in the activity of "liver" transaminases, alkaline phosphatase, hyperuricemia.

Overdose:

Acute overdose of xanthinal nicotinate is accompanied by a decrease in blood pressure, weakness, dizziness, tachycardia, abdominal pain and vomiting. When symptoms of an overdose appear symptomatic therapy.

Interaction:

Caution should be exercised with the simultaneous administration of xanthinal nicotinate and antihypertensive medications, including (beta-blockers, alpha-blockers, sympatholytics, ganglioblocators). Do not use in conjunction with monoamine oxidase inhibitors and strophanthin (strophanthin-K).

Special instructions:

The drug may cause dizziness, weakness and low blood pressure,in connection with this, during the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Avoid contact with eyes or mucous membranes.

Form release / dosage:

Solution for intramuscular and intravenous administration of 150 mg / ml 2 ml in ampoules.

Packaging:

5 ampoules per contour cell packaging made of polyvinyl chloride film. 1 or 2 contoured cell packs with scarifier ampoule ceramic or knife for opening ampoules and instructions for use in a pack of cardboard. When using ampoules with a fracture ring or break point, the knife or scarifier is not inserted.

Storage conditions:

Store in a dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years. Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LP-001267

Date of registration:24.11.2011 / 11.11.2015

Expiration Date:24.11.2016

The owner of the registration certificate:BINNOFARM, CJSC BINNOFARM, CJSC Russia

Manufacturer: & nbsp

BINNOFARM, CJSC Russia

Information update date: & nbsp24.01.2018

Illustrated instructions

Instructions

Xantinol nicotinate (Xantinol nicotinate)