Xantinol nicotinate - instructions for use, dose, side effects, contraindications

Xanthinal nicotinate combines the properties of drugs of the theophylline and nicotinic acid group: it has antiaggregant effect, expands peripheral vessels, improves collateral circulation.Blocking adenosine receptors and phosphodiesterase, increases the content of cyclic adenosine monophosphate in the cell, substrate stimulates the synthesis of nicotinamide dinucleotide and nicotinamide dinucleotide phosphate. Improves microcirculation, oxygenation and nutrition of tissues, with prolonged use has antiatherosclerotic effect, activates the processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, enhances the activity of lipoprotein lipase, reduces the viscosity of blood, reduces platelet aggregation.

Reducing the overall peripheral vascular resistance and strengthening myocardial contractions, contributes to an increase in the minute volume of blood and increased cerebral circulation, reduces the severity of cerebral hypoxia.

Xanthinal nicotinate causes a "nicotine-like" syndrome, accompanied by hyperesthesia of the mucous membrane of the nasal cavity and mouth: exacerbates the sensitivity of olfactory and taste sensations. In this regard, the smell and taste of the alcoholic beverages offered during the "nicotine-like" reaction is perceived to be more harsh and unpleasant.

Indications:

In the complex therapy: obliterating atherosclerosis of the vessels of the extremities, Raynaud's disease, obliterating endarteritis, diabetic angiopathy, acute thrombophlebitis (of the superficial and deep veins), trophic ulcers of the shins, cerebrovascular insufficiency; atherosclerosis of cerebral vessels, cerebral circulatory disorders, coronary artery atherosclerosis, hypercholesterolemia, hypertriglyceridemia.

Contraindications:

Hypersensitivity, acute heart failure or decompensated chronic heart failure, acute bleeding, acute myocardial infarction, mitral stenosis, ulcerative disease of the stomach and duodenum (in the phase of exacerbation), arterial hypotension, acute renal failure, glaucoma. Do not use in conjunction with monoamine oxidase inhibitors.

Carefully:

Pregnancy and lactation:

During pregnancy and lactation, the use of the drug is permissible only in the presence of absolute indications and careful observation of the doctor.

Dosing and Administration:

Intravenous (jet or drip), intramuscularly.

In acute circulatory disorders xanthinal nicotinate Enter intramuscularly 300 mg (2 ml) 1-3 times a day. Depending on the nature of the disease, the dose can be gradually increased to 600 mg (4 ml) 2-3 times a day. The duration of therapy is determined by the doctor, an average of 2-3 weeks.

In a hospital xanthinal nicotinate injected intravenously struino - 300 mg (2 ml) 1-2 times a day for 5-10 days. The patient must be in a horizontal position.

The drug can be injected intravenously at a rate of 40-50 drops per minute for 1.5-4 hours. To do this, a single dose of the drug is diluted in 200-500 ml of a 5% dextrose solution or in 200 ml of a 0.9% solution of sodium chloride.

Side effects:

Reduction of blood pressure, fever, hyperemia of the skin, weakness, dizziness, nausea, diarrhea, decreased appetite, gastralgia. With long-term administration in high doses, a change in glucose tolerance, an increase activity of "liver" transaminases alkaline phosphatase, hyperuricemia.

Overdose:

Symptoms: lowering blood pressure, abdominal pain, vomiting.

Treatment: symptomatic.

Interaction:

Caution should be exercised with the simultaneous administration of xanthinal nicotinate and antihypertensive medications (beta-blockers, ergot alkaloids, alpha-adrenergic blockers, sympatholytic drugs,ganglion blockers), as well as strophanthin (strophanthin-K) (possibly a sharp increase in their effect).

Special instructions:

Avoid contact with eyes or mucous membranes.

Effect on the ability to drive transp. cf. and fur:Large doses of the drug may cause dizziness, weakness and arterial hypotension, therefore, one should refrain from driving a vehicle and working with mechanisms.

Form release / dosage:

Solution for intravenous and intramuscular injection 150 mg / ml.

Packaging:2 ml each into neutral glass ampoules of grade НС-3 or USP-1. 10 ampoules are placed in boxes of cardboard. In each box, the instructions for use and the ampoule scaler are put.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N002899 / 01

Date of registration:29.09.2008 / 29.12.2011

Expiration Date:Unlimited

The owner of the registration certificate:MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia

Manufacturer: & nbsp

MOSHIMFARM PREPARATES them. NA Semashko OJSC Russia

Information update date: & nbsp24.01.2018

Illustrated instructions

Instructions

Xantinol nicotinate (Xantinol nicotinate)