Xantinol nicotinate - instructions for use, dose, side effects, contraindications

Xanthinal nicotinate combines the properties of drugs of the theophylline and nicotinic acid group: it has antiplatelet effect; expands peripheral vessels, improves collateral circulation.Blocking adenosine receptors and phosphodiesterase, increases the content of cyclic adenosine monophosphate (cAMP) in the cell, substrate stimulates the synthesis of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADO).
Improves microcirculation, oxygenation and nutrition of tissues. With prolonged use has antiatherosclerotic effect, activates processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, increases the activity of lipoprotein lipase, reduces the viscosity of the blood, reduces the aggregation of platelets.
Reducing overall peripheral vascular resistance and strengtheningwith myocardial staining, increases the minute volume blood circulation and strengthening, cerebral circulation, reduces the severity of the consequences of cerebral hypoxia.

Indications:

As part of complex therapy:

- obliterating atherosclerosis of the vessels of the extremities,

- Rhineb's disease,

- obliterating endarteritis,

- diabetic angiopathy,

- acute thrombophlebitis (superficial and deep veins),

- trophic ulcers of the shins,

- cerebrovascular insufficiency,

- atherosclerosis of cerebral vessels,

- disorders of cerebral circulation,

- atherosclerosis of the coronary arteries,

- hypercholesterolemia, hypertriglyceridemia.

Contraindications:

Hypersensitivity, acute heart failure or

decompensated chronic heart failure; acute bleeding, acute myocardial infarction, mitral stenosis, ulcerative stomach disease andduodenal ulcers in the phase of exacerbation, arterial hypotension, pregnancy, acute renal failure,

glaucoma, increased individual sensitivity to the components of the drug.

The drug is not used in children younger than 2 years, because it includes a component theophylline.

Carefully:not described

Pregnancy and lactation:

Do not use in the first trimester of pregnancy. In the second and third trimester pregnancy and lactation, the use of the drug is permissible only if there are absolute indications and careful monitoring of the doctor for patient.

Dosing and Administration:

Intramuscularly, intravenously (struino or drip). In acute disorders of the blood supply of tissues, the drug is administered intramuscularly at 0.3 g (2 ml of the drug) 1 - 3 times a day. Depending on the from the nature of the disease, the dose can be gradually increased to 0.6-0.9 g (4 - 6 ml of the drug) 2-3 times a day. Duration of treatment is 2-3 of the week.

The drug is injected intravenously slowly in 0.3 g (2 ml of the drug) 1-2 times a day (the patient should be in a horizontal position). The duration of treatment is 5-10 days.

In acute violations of peripheral and cerebral circulation the drug is administered intravenously-dropwise at a rate of 40-50 drops in minute. To do this, 1.5 g (10 ml) of the drug is diluted in 200 - 500 ml 5% glucose solution or 200 ml isotonic sodium solution chloride, the resulting infusion mixture is administered dropwise for 1.5 to 4 hours. Infusion can be repeated up to 4: once a day; durability treatment is 5-10 days.

Side effects:

From the side of the cardiovascular system: possibly lowering blood pressure, dizziness, a feeling of heat, redness of the skin.

From the digestive system: nausea, diarrhea, anorexia, gastralgia.

Other: weakness, tingling of the skin, especially in the head and neck. These symptoms usually disappear after 10-20 minutes, do not require special treatment and refusal to use this drug ..

With long-term administration in high doses, the drug causes a change in glucose tolerance, an increase in the activity of "liver" transaminases, alkaline phosphatase and serum uric acid levels blood.

When unwanted effects appear, not described in this manual, and the increase in the above-mentioned side effects in the treatment with this drug should be reported immediately to the treating physician.

Overdose:

The drug is low toxicity. Acute overdose of xanthinal nicotinate accompanied by arterial hypotension, general weakness, dizziness, tachycardia, abdominal pain and vomiting. When symptoms of an overdose appear symptomatic therapy.

Interaction:

To avoid a sharp drop in blood pressure, the drug can not be apply simultaneously with antihypertensive drugs. Do not use simultaneously with MAO inhibitors, strophanthin.

Special instructions:

Xanthinal nicotinate causes a "nicotine-like" syndrome, accompanied by hyperesthesia of the nasal mucosa and mouth (exacerbates the sensitivity of olfactory and taste buds) in
Due to this, the smell and taste of alcoholic beverages taken during therapy is perceived to be more abrupt and perverted.

When diabetes is necessary to carefully monitor glycemia.

Patients with an implanted pacemaker use the drug in a lower dose.

Avoid contact with eyes or mucous membranes.

Effect on the ability to drive transp. cf. and fur:

Large doses of the drug may cause dizziness, weakness and arterial hypotension, in this connection it is necessary to refrain from management of a vehicle, working with mechanisms and employment, other potentially dangerous activities, requiring increased concentration and speed psychomotor reactions.

Form release / dosage:

Solution for solution for intravenous and intramuscular administration of 150 mg / ml.
Pabout 2 ml or 10 ml into neutral glass ampoules.
For 10 ampoules with instructions for use and a knife ampoule or scarifier ampoule placed in a box of cardboard.

For 5 or 10 ampoules are placed in a contour mesh package made of polyvinyl chloride or polyethylene terephthalate tape and aluminum foil, or paper with polyethylene coating, or without foil, or without paper.
For 1 or 2 contour mesh packages with instructions for use and 1 staple ampoule or scarifier ampullum is placed in a pack of cardboard.

When you pack the ampoules with a break ring or break point, the ampoule opener or ampoule scapper does not insert.

Packaging:Pack of cardboard

Storage conditions:

In the dark place at a temperature of 15 to 25 ° C Keep out of reach of children.

Shelf life:

3 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-001527

Date of registration:21.02.2012

The owner of the registration certificate:NOVOSIBHIMFARM, OJSC NOVOSIBHIMFARM, OJSC Russia

Manufacturer: & nbsp

NOVOSIBHIMFARM, OJSC Russia

Information update date: & nbsp21.02.2012

Illustrated instructions

Instructions

Xantinol nicotinate (Xantinol nicotinate)