Xantinol nicotinate - instructions for use, dose, side effects, contraindications

Xanthinal nicotinate combines the properties of drugs of the theophylline and nicotinic acid group: it has anti-aggregative effect, expands peripheral vessels, improves collateral circulation.

Blocking adenosine receptors and phosphodiesterase, increases the content of cyclic adenosine monophosphate in the cell, substrate stimulates the synthesis of nicotinamide dinucleotide and nicotinamide dinucleotide phosphate. Improves microcirculation, oxygenation and nutrition of tissues, with prolonged use activates the processes of fibrinolysis, reduces cholesterol and atherogenic lipids, increases lipoprotein lipase activity, reduces blood viscosity, reduces platelet aggregation.

Reducing the overall peripheral vascular resistance, contributes to an increase in the minute volume of blood and increased cerebral circulation, reduces the severity of cerebral hypoxia.

Pharmacokinetics:

Indications:

As part of complex therapy: obliterating atherosclerosis, vessels extremities, Raynaud's disease, obliterating endarteritis, diabetic angiopathy, acute thrombophlebitis (superficial and deep veins), trophic ulcers of the lower legs, cerebrovascular insufficiency, cerebral arteriosclerosis, cerebral circulatory disorders, coronary artery atherosclerosis, hypercholesterolemia, hypertriglyceridemia.

Contraindications:

Hypersensitivity, acute heart failure or decompensated chronic heart failure, acute bleeding, acute myocardial infarction, mitral stenosis, gastric and duodenal ulcer (in the phase of exacerbation), arterial hypotension, pregnancy (especially in the first trimester) and lactation period, acute renal failure , glaucoma.

Carefully:not described

Pregnancy and lactation:

The use of the drug during pregnancy is possible only if prescribed by the doctor in the event that the intended benefit to the mother exceeds the potential risk to the fetus.

If you need to take the drug during lactation, it is necessary to interrupt breastfeeding.

Dosing and Administration:

Intravenous (jet or drip), intramuscularly.

The degree of severity of the disease, the condition of the patient and the route of administration of the drug are evaluated by a doctor.

With intramuscular injection - 2-6 ml 15 % solution daily for 2-3 weeks.

With intravenous jet injection - 2 ml 15 % solution 1-2 times a day for 5-10 days (the patient should be in a horizontal position).

When intravenous drip introduction - at a speed of 40-50 drops / min, diluting 10 ml 15 % solution in 200-500 ml of a 5% solution of dextrose (glucose) or in 200 ml of 0.9 % solution of sodium chloride.

Side effects:

Decrease in blood pressure, fever, hyperemia and tingling of the upper body, especially the neck and head, weakness, golovruzhenie, nausea, diarrhea, decreased appetite, gastralgia. These symptoms usually disappear after 10-20 minutes and do not require special treatment and discontinuation of therapy with this drug.

With prolonged use of high doses, a decrease in glucose tolerance, an increase in the activity of "liver" transaminases and alkaline phosphatase, hyperuricemia.

Overdose:

Symptoms: lowering blood pressure, weakness, dizziness, abdominal pain, vomiting.

Treatment: symptomatic.

Interaction:

Caution should be exercised with the simultaneous administration of xanthinal nicotinate and antihypertensive medications (beta-blockers, alkaloids ergot, alpha-adrenoblockers, sympatholytic, ganglion blockers).

Do not use in conjunction with MAO (monoamine oxidase) inhibitors and strophanthin.

Special instructions:

In the second and third trimester of pregnancy and during lactation, the use of the drug is permissible only in the presence of absolute indications and careful observation of the doctor.

Avoid contact with eyes or mucous membranes.

Effect on the ability to drive transp. cf. and fur:During the treatment period, care should be taken when driving and potentially dangerous mechanisms due to possible dizziness, weakness and lower blood pressure.

Form release / dosage:

Solution for intravenous and intramuscular injection 150 mg / ml.

To 2 ml in the ampoules of neutral glass HC-3.

For 10 ampoules together with instructions for use in a pack of cardboard. Packs are pasted with a label-parcel. It is allowed to put the text of the label-parcel directly on the packet.

5 ampoules per contour mesh box made of polyvinylchloride film and aluminum foil, or paper wrapped with polymer coating, or without paper and foil.

2 contour packs with instructions for use in a pack of cardboard and paste the label-parcel. It is allowed to put the text of the label-parcel directly onto the pack.

In each pack insert knife ampoule or scarifier.

When packaging ampoules with a dot or ring fracture, the ampoule opener or scarifier is not inserted.

Storage conditions:

Store in a dark place at a temperature of no higher than 30 ° C.

Keep out of the reach of children.

Shelf life:

Shelf life 2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-000060

Date of registration:01.12.2010

The owner of the registration certificate:Armavir Biofactory, FKPArmavir Biofactory, FKP Russia

Manufacturer: & nbsp

Armavir Biofactory, FKP

Information update date: & nbsp12.12.2014

Illustrated instructions

Instructions

Xantinol nicotinate (Xantinol nicotinate)