Xanthinal nicotinate-UBF - instructions for use, dose, side effects, contraindications

The drug combines the properties of substances of theophylline and nicotinic acid: causes the expansion of peripheral vessels, improves collateral circulation, improves oxygenation and nutrition of tissues,enhances oxidative phosphorylation and the synthesis of adenosine triphosphate (ATP). Xantinol nicotinate improves cerebral circulation and reduces the phenomenon of cerebral hypoxia. The drug also activates the processes of fibrinolysis, reduces the aggregation of platelets.

Pharmacokinetics:

Xantinol nicotinate is rapidly absorbed in the digestive tract, evenly distributed to all organs and tissues. Dissociates with the formation of xanthinal and nicotinic acid. Metabolism of theophylline is carried out in the liver. Half-life T_1/2 variable - shortens in smokers, with chronic alcoholism, admission of carbamazepine, barbiturates, rifampicin; lengthened with cirrhosis of the liver, heart failure, as well as with the use of cimetidine, ciprofloxacin, erythromycin and oral contraceptives. These changes are of clinical importance, since theophylline characterized by a small breadth of therapeutic effect. Bronchodilating effect of theophylline, as a rule, develops at a concentration in blood plasma equal to 10-20 mg / l. However, when creating such concentrations, side effects usually develop, the frequency and severity of which increases at higher concentrations.

Metabolism of theophylline occurs predominantly in the liver, 5-20% of methylxanthine derivatives are excreted unchanged in the urine.

Indications:Obliterating atherosclerosis and endarteritis of the vessels of the lower extremities; diabetic angiopathy; retinopathy; acute thrombophlebitis of the superficial and deep veins; trophic ulcers of the lower extremities; disturbance of cerebral circulation.

Contraindications:

Acute heart failure, acute myocardial infarction, chronic cardiac insufficiency IIB-III degree, acute hepatic insufficiency, arterial hypotension, acute bleeding, mitral stenosis, pregnancy, lactation, peptic ulcer disease, glaucoma, childhood, increased individual sensitivity to the drug components, lactose deficiency, lactose intolerance, glucose-galactose malabsorption.

Dosing and Administration:Apply the inside after meal, starting with 150 mg 3 times a day, if necessary dose, increase to 300-600 mg 3 times a day. Tablets are taken without chewing. As the patient's condition improves, the dose is reduced to 150 mg 2-3 times a day.The course of treatment usually lasts at least 2 months. Repeated course is possible after consulting a doctor.

Side effects:

Xanthinal nicotinate can cause dizziness, lower blood pressure, general weakness, hot sensations, - tingling and redness of the upper body, especially the neck and head, nausea, diarrhea. These symptoms usually disappear after 10-20 minutes, do not require special treatment and discontinuation of therapy with this drug. When unwanted effects are not described in this instructions, and reinforcing the above-mentioned side effects when taking this medication, you should immediately inform your doctor about it.

With prolonged use in high doses, the drug causes a change in glucose tolerance, increased activity of "liver" transaminases, alkaline phosphatase, hyperuricemia.

If any of the side effects indicated in the manual are aggravated, or if you notice any other side effects not listed in the instructions, report this doctor.

Overdose:Acute overdose of xanthinal with nicotinate is accompanied by a decrease in blood pressure, general weakness, dizziness, tachycardia, abdominal pain and vomiting.When symptoms of an overdose appear symptomatic therapy.

Interaction:

To avoid a sharp drop in blood pressure, the drug should not be used simultaneously with antihypertensive drugs. It can not be combined with therapy with inhibitors of the enzyme monoamine oxidase, uabain.

Special instructions:

Xanthinal nicotinate is used with caution in labile arterial pressure.

When taking the drug in doses exceeding therapeutic, it is possible to lower blood pressure, dizziness, weakness.

During the treatment with xanthine, nicotinate can not be consumed with alcoholic beverages, since the drug causes a "nicotine-like" syndrome accompanied by hyperesthesia of the mucous membrane of the nose and mouth (sharpens the sensitivity of the olfactory and taste buds). Therefore, the smell and taste of alcoholic beverages taken during therapy is perceived as sharp and perverted.

Effect on the ability to drive transp. cf. and fur:When taking Xanthinal nicotinate, you should refrain from driving vehicles and practicing potentially hazardous activities.

Form release / dosage:

Tablets of 150 mg.

Packaging:

For 10 tablets in a contour non-cellular package of paper with polyethylene coating.

10 tablets per contour cell packaging made of polyvinylchloride film and aluminum foil or paper with a polymer coating.

By 20, 30, 40, 50, 60, 100 tablets in cans of polymeric.

Each jar or 1, 2, 3, 4, 5 contour mesh or contour non-jawed packages together with the instruction for use are placed in a bundle.

Banks polymeric, or contour non-cellular packages, or contour mesh packages with an equal number of instructions for use are placed in a bag of polyethylene film or a cardboard box.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N002055 / 01

Date of registration:06.11.2008 / 11.09.2012

Expiration Date:Unlimited

The owner of the registration certificate:URALBIOFARM, OJSC URALBIOFARM, OJSC Russia

Manufacturer: & nbsp

URALBIOFARM, OJSC Russia

Information update date: & nbsp24.01.2018

Illustrated instructions

Instructions

Xanthinal nicotinate-UBF (Xantinol nicotinate-UBF)