Active substanceXantinol nicotinateXantinol nicotinate
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  • Dosage form: & nbsppills
    Composition:

    For one tablet

    Active substance: xanthinal nicotinate - 0.15 g,

    auxiliary substances (potato starch, milk sugar, low molecular weight polyvinylpyrrolidone, calcium stearate) to a tablet weighing 0.23 g.

    Description:Tablets of white or almost white color are flat-cylindrical with a facet and a risk.
    Pharmacotherapeutic group:Antiaggregate agent
    ATX: & nbsp

    C.04.A.D.02   Xantinol nicotinate

    Pharmacodynamics:

    The drug combines the properties of theophylline and nicotinic acid: causes the expansion of peripheral vessels,improves collateral circulation, improves oxygenation and nutrition of tissues, enhances oxidative phosphorylation and synthesis of ATP. Xantinol nicotinate improves cerebral circulation and reduces the phenomenon of cerebral hypoxia. The drug also activates the processes of fibrinolysis, reduces the aggregation of platelets.

    Indications:

    Obliterating atherosclerosis and endarteritis of the vessels of the lower limbs; diabetic angiopathy; retinopathy; acute thrombophlebitis of the superficial and deep veins; construct a bofbébi- tic syndrome; trophic ulcers of the lower extremities; pressure sores; Meniere's syndrome; Dermatoses associated with a disorder of vascular trophism; disturbance of cerebral circulation.

    Contraindications:

    Acute heart failure, including acute myocardial infarction; chronic heart failure IIB-III degree; mitral stenosis; arterial hypertension; acute bleeding; pregnancy I trimester; peptic ulcer of the stomach and 12 duodenal ulcer in the stage of exacerbation; acute renal insufficiency; glaucoma; childhood; increased individual sensitivity to the components of the drug.

    Pregnancy and lactation:In the second and third trimester of pregnancy and during lactation, the use of the drug is permissible only in the presence of absolute indications and careful observation of the doctor.
    Dosing and Administration:

    Apply inside after meals, starting with 150 mg 3 times a day, if necessary, increase the dose to 300-600 mg 3 times a day. Tablets are taken without chewing. As the patient's condition improves, the dose is reduced to 150 mg 2-3 times a day. The course of treatment usually lasts at least 2 months. Repeated course is possible after consulting a doctor.

    Side effects:

    Xanthinal nicotinate can cause dizziness, lower blood pressure, general weakness, a feeling of heat, tingling and redness of the upper body, especially the neck and head, nausea, anorexia, diarrhea. These symptoms usually disappear after 10-20 minutes, do not require special treatment and discontinuation of therapy with this drug. If unwanted effects not described in this manual occur and if the above side effects are increased with this medication, tell your doctor immediately.

    With long-term administration in high doses, the drug causes a change in tolerance toglucose, increased activity of "liver" transaminases, alkaline phosphatase, hyperuricemia.

    Overdose:The drug is slightly toxic. Acute overdose of xanthinal nicotinate is accompanied by arterial hypotension, general weakness, dizziness, tachycardia, abdominal pain and vomiting. When symptoms of an overdose appear symptomatic therapy.
    Interaction:

    To avoid a sharp decrease in blood pressure, the drug should not be used simultaneously with antihypertensive drugs. It can not be combined with therapy with MAO inhibitors, strophanthin.

    Special instructions:

    Xanthinal nicotinate causes a "nicotine-like" syndrome, accompanied by hyperesthesia of the mucous membrane of the nose and mouth (exacerbates the sensitivity of the olfactory and taste buds) in this regard, the smell and taste of alcoholic beverages taken during therapy is perceived to be more abrupt and perverted.

    Effect on the ability to drive transp. cf. and fur:Large doses of the drug may cause dizziness, weakness and arterial hypotension, therefore, one should refrain from driving a vehicle and working with mechanisms.
    Form release / dosage:

    Tablets of 0.15 g.

    Packaging:For 10 tablets per contour cell or cell-free packaging, 30 or 60 tablets per can of polymer. Each jar or 3, 6 contour squares, together with the instruction for use, is placed in a cardboard pack.
    Storage conditions:

    List B. In a dry, dark place, out of the reach of children.

    Shelf life:3 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:P N003485 / 01
    Date of registration:05.06.2009 / 24.10.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.01.2018
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