alpha-Tocopherol acetate (Vitamin E) - instructions for use, dose, side effects, contraindications

Vitamin E is an antioxidant. Protects the cellular membranes of body tissues from oxidative changes; stimulates the synthesis of heme and heme-containing enzymes - hemoglobin, myoglobin, cytochromes, catalase, peroxidase. It inhibits the oxidation of unsaturated fatty acids and selenium. Inhibits the synthesis of cholesterol. Prevents hemolysis of erythrocytes, increased permeability and fragility of capillaries, disruption of the function of the seminiferous tubules and testicles, placenta, normalizes reproductive function.

Pharmacokinetics:

Absorption from 12 duodenumwki (requires the presence of bile salts, fats, normal pancreatic function) - 50 - 80%. It binds to the beta-lipoproteins of the blood. If there is a violation of protein metabolism, transport is difficult. TS_max - 4 hoursIt is deposited in all organs and tissues, especially in adipose tissue. Penetrates through the placenta in insufficient quantities: in the blood of the fetus penetrates 20-30% of the concentration in the blood of the mother. Penetrates into breast milk. Metabolised in the liver to derivatives that have a quinone structure (some of them have vitamin activity). It is excreted with bile - more than 90% (some amount is again absorbed and subjected to enterohepatic circulation), kidneys - 6% (in the form of glucuronides of tocopheronic acid and its gamma-lactone).

Indications:

Hypovitaminosis E.
In complex therapy: muscular dystrophy; dermatomyositis; atherosclerosis, myocardiodystrophy; disorders of the menstrual cycle; threats of abortion, disorders of the sexual glands in men; dermatoses, psoriasis.

Contraindications:

Increased individual sensitivity to the components of the drug, acute myocardial infarction, children's age.

Carefully:Hypoprothrombinemia, severe cardiosclerosis, advanced myocardial infarction myocardium, an increased risk of thromboembolism.

Pregnancy and lactation:

The drug in this dosage is not recommended for use in normal pregnancy.For pregnant and lactating mothers, a dose of vitamin E is recommended - 10-14 mg.

Dosing and Administration:

Inside for 100-300 mg / day, if necessary up to 1 g / day.

In diseases of the neuromuscular system - 100 mg per day for 1-2 months. Repeated courses in 2-3 months.

With violations of spermatogenesis and potency - 100 - 300 mg per day in combination with hormone therapy for a month.

When threatening abortion - 100 mg per day for 7-14 days, with the usual abortion and deterioration of fetal development - 100 mg per day for the first 2-3 months of pregnancy every day or every other day.

With peripheral vascular diseases, myocardial dystrophy, atherosclerosis - at 100 mg per day (with vitamin A) for 20-40 days, after 3-6 months the course of treatment can be repeated.

In dermatology - 100 mg per day for 20 to 40 days.

Side effects:

Allergic reactions, dyspepsia are possible.

Overdose:

Symptoms: when taking vitamin E for a long period in doses of 400-800 mg / day: - blurred vision, dizziness, headache, nausea, fatigue, diarrhea, gastralgia, asthenia.

When taking more than 800 mg / day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, a metabolic disorder of thyroid hormones,disorders of sexual function, thrombophlebitis, thromboembolism, necrotic colitis, sepsis, hyperbilirubinemia, renal failure, hemorrhage in the retina, hemorrhagic stroke, ascites.

Treatment: symptomatic. Cancellation of the drug, the appointment of glucocorticosteroid drugs.

Interaction:

Vitamin E enhances the effect of glucocorticosteroid drugs, non-steroidal anti-inflammatory drugs, cardiac glycosides.

Reduces the effectiveness and toxicity of vitamins A and D. PovyshThe effectiveness of antiepileptic drugs in patients with epilepsy is high.

It is not recommended to simultaneously take other multivitamin complexes containing vitamin E, in order to avoid an overdose.

Simultaneous intake of large doses of vitamin E with iron, vitamin K or anticoagulants (agents that prevent blood clotting) increases the clotting time.

Special instructions:

Do not exceed the recommended dosage. Do not take twice the dose if you missed the previous dose.

Form release / dosage:

Capsules 100 mg.

Packaging:

10 capsules per circuit cell packaging from film floorandvinyl chloride and paper with a polymer coating or aluminum foil printed lacquered.

By 2, 3, 4 contour mesh packages along with the instruction for use are placed in a pack of chromium-ersatz cardboard or cardboard box.

1, 2, 3, 5, 10, 20, 50 contour mesh packages, together with an equal number of instructions for use, are placed in a polyethylene hermetically sealed bag of lightproof polyethylene film, or of a material combined on paper and cardboard basis, or from a combined " Buflen ", or from a two-layer combined material.

50, 100, 200, 400, 600 contour mesh packages together with an equal number of instructions for use are placed in a sealed polyethylene hermetically sealed bag of light-tight polyethylene film.

Polyethylene packaging is placed in a cardboard box.

For hospitals 50, 100, 200, 400, 600 contour cells, together with the instruction for use, are placed in a cardboard box.

Storage conditions:

Keep in dry the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N001777 / 01

Date of registration:10.12.2008

Expiration Date:Unlimited

The owner of the registration certificate:LYUMI, LLC LYUMI, LLC Russia

Manufacturer: & nbsp

LYUMI, LLC Russia

Representation: & nbspLYUMI, LLCLYUMI, LLC

Information update date: & nbsp17.07.2017

Illustrated instructions

Instructions

alpha-Tocopherol acetate (Vitamin E) (alfa-Tocopherol acetate (vitamin E))