Alpha-tocopherol acetate (Alfa-tocopherol acetate)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceVitamin EVitamin E
Dosage form: & nbspcapsules
Composition:

For 1 capsule:

Active substance:

Alpha-tocopherol acetate (vitamin E) - 100 mg

Excipient:

Sunflower oil - 100 mg

The composition of the capsule shell in terms of absolutely dry matter: gelatin - 15.00 mg, glycerol - 4.73 mg, methyl parahydroxybenzoate - 0.07 mg, dye Red charming (E-129) - 0.30 mg, purified water 39.90 mg

Weight of capsule contents - 200 mg

Capsule weight with contents - 260 mg

Description:

Soft gelatin capsules spherical in red, filled with oily liquid from light yellow to dark yellow color, without a rancid smell.

Pharmacotherapeutic group:Vitamin
ATX: & nbsp
  • Tocopherol (vitamin E)
    • Pharmacodynamics:Fat-soluble vitamin, is an antioxidant. Participates in the biosynthesis of heme and proteins, cell proliferation, tissue respiration, and other important processes of tissue metabolism; protects tissues from damaging effects of excess amounts of free radicals and peroxide products; stimulates the synthesis of proteins and collagen.
    Pharmacokinetics:

    Absorption from the duodenum (requires the presence of bile salts, fats, normal function of the pancreas) - 50-80%. It binds to beta-lipoproteins of blood. If there is a violation of protein metabolism, transport is difficult. TSmax- 4 hoursIt is deposited in all organs and tissues, especially in adipose tissue. Penetrates through the placenta in insufficient quantities: in the blood of the fetus penetrates 20-30% of the concentration in the blood of the mother. Penetrates into breast milk. Metabolised in the liver to derivatives that have a quinone structure (some of them have vitamin activity). It is excreted with bile - more than 90% (some amount is again absorbed and subjected to enterohepatic circulation), kidneys - 6% (in the form of glucuronides of tocopheronic acid and its gamma-lactone).

    Indications:

    Treatment and prevention of vitamin E vitamin deficiency.

    Contraindications:Increased individual sensitivity to the components of the drug, acute myocardial infarction, children under 18 years of age.
    Carefully:

    Hypoprothrombinemia caused by vitamin K deficiency, severe cardiosclerosis, myocardial infarction, increased risk of thromboembolism.

    Pregnancy and lactation:

    The use of the drug during pregnancy and during breastfeeding is possible only according to the doctor's prescription.

    Dosing and Administration:Inside, 2-4 capsules per day, for 1-2 weeks.
    Side effects:

    From the immune system: allergic reactions (itching, skin hyperemia); from the gastrointestinal tract: diarrhea, nausea, gastralgia, dyspepsia.

    Overdose:

    Symptoms: when taking vitamin E for a long period in doses of 400-800 mg / day - blurred vision, dizziness, headache, nausea, fatigue, diarrhea, gastralgia, asthenia.

    When taking more than 800 mg / day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, a disorder of thyroid hormone metabolism, a disorder of sexual function, thrombophlebitis, thromboembolism, necrotic colitis, sepsis, hyperbilirubinemia, renal failure, haemorrhage in the retina , hemorrhagic stroke, ascites.

    Treatment: abolition of the drug, the appointment of glucocorticosteroid drugs; symptomatic therapy.

    Interaction:

    Vitamin E enhances the effect of glucocorticosteroid drugs, non-steroidal anti-inflammatory drugs, cardiac glycosides.

    The appointment of vitamin E in high doses can cause vitamin A deficiency in the body. Simultaneous use of vitamin E in a dose of more than 400 mg / day with anticoagulants (coumarin derivatives andindandion) increases the risk of hypoprothrombinemia and bleeding. Kolestyramine, colestipol, mineral oils reduce the absorption of alpha-tocopherol acetate. With the simultaneous use of vitamin E with cyclosporin, the absorption of the latter increases.

    Special instructions:

    Do not exceed the recommended dose.

    Effect on the ability to drive transp. cf. and fur:

    The use of the drug does not affect the performance of potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions (dispatcher work, vehicle management, work with moving mechanisms).

    Form release / dosage:

    Capsules 100 mg.

    Packaging:

    10, 20, 30 capsules in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

    By 1, 2, 3, 4 contour mesh packs together with instructions for use are placed in a pack of cardboard.

    For hospitals: 50, 100, 200 contour cell packs, together with an equal number of instructions for use, are placed in boxes of corrugated cardboard.

    By 20, 30, 40 capsules in cans of polymeric with polymer caps.

    Each bank along with the instruction for use is placed in a pack of cardboard.For hospitals: 42 or 54 cans, together with an equal number of instructions for use, are placed in boxes of corrugated cardboard.

    Storage conditions:

    Store in a dry, dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.
    Shelf life:2 years.
    Do not use after expiry date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LP-003534
    Date of registration:29.03.2016
    Expiration Date:29.03.2021
    The owner of the registration certificate:TULA PHARMACEUTICAL FACTORY, LTD. TULA PHARMACEUTICAL FACTORY, LTD. Russia
    Manufacturer: & nbsp
    Information update date: & nbsp17.07.2017
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