- Hypersensitivity to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs) or xanthines; hypersensitivity to other components of the drug;
- erosive and ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation), gastrointestinal bleeding;
- marked violations of the liver or kidneys;
- asthma induced by the use of acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs;
- hemorrhagic diathesis (von Willebrand's disease, hemophilia, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);
- exfoliating aortic aneurysm;
- deficiency of glucose-6-phosphate dehydrogenase;
- portal hypertension, vitamin K deficiency;
- increased excitability, sleep disturbance, anxiety disorders (agoraphobia, panic disorder);
- organic diseases of the cardiovascular system (acute myocardial infarction, severe course of coronary heart disease, arterial hypertension), paroxysmal tachycardia, frequent ventricular extrasystole;
- glaucoma;
- surgical interventions accompanied by bleeding;
- children under 15 years.