Citramon P - instructions for use, dose, side effects, contraindications

Excipients: cocoa - 14 mg, citric acid - 5 mg, potato starch - 63 mg, povidone low molecular weight (polyvinylpyrrolidone low molecular weight medical) - 4 mg, talc - 9 mg, calcium stearate - 5 mg.

Description:

tablets of light brown color with impregnations, flat-cylindrical with a facet and a risk, with the smell of cocoa.

Pharmacotherapeutic group:Analgesic agent (analgesic non-narcotic remedy + psychostimulant + nassteroid anti-inflammatory drug).

ATX: & nbsp

N.02.B.A.51 Acetylsalicylic acid in combination with other drugs, excluding psycholeptics

Pharmacodynamics:

Combined drug.

Acetylsalicylic acid has antipyretic and anti-inflammatory effect, relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and thrombosis, improves microcirculation in the inflammatory focus.

Caffeine increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, dilates the blood vessels of skeletal muscles, the head brain, heart, kidneys, reduces platelet aggregation; reduces drowsiness, fatigue. In this combination caffeine in a small dose practically does not have a stimulating effect on the central nervous system, but it contributes to the regulation of the tone of the vessels of the brain.

Paracetamol has an analgesic, antipyretic and weak anti-inflammatory effect, which is associated with its influence on the center of thermoregulation in the hypothalamus and a weakly expressed ability to inhibit the synthesis of prostaglandins (Pg) in peripheral tissues.

Pharmacokinetics:

Indications:

Pain syndrome of mild and moderate severity (of various origins): headache, migraine, toothache, neuralgia, myalgia, arthralgia, algodismenorea.Feverish syndrome: with acute respiratory diseases (ARI), influenza.

Contraindications:

■ Stomach ulcer and duodenal ulcer in the phase of exacerbation;

■ Gastrointestinal hemorrhage (including in the anamnesis);

■ Pronounced violations of the liver and / or kidney function, gout;

■ Hemorrhagic diathesis, hypocoagulation;

■ Surgical interventions accompanied by heavy bleeding;

■ Pregnancy (I and III trimester), lactation period;

■ Deficiency of glucose-6-phosphate dehydrogenase;

■ Glaucoma;

■ Hypersensitivity to the components of the drug, asthma, induced by the use of acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs;

■ Children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases);

■ Increased excitability, sleep disturbance;

■ Organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis);

■ Severe arterial hypertension

■ Portal hypertension

■ Avitaminosis To

■ Gyenoproteinemia

Carefully:

■ Renal failure of mild to moderate degree, hepatic insufficiency with an increase in the level of transamipase, benign hyperbilirubinemia (incl.Gilbert's syndrome, alcoholic liver damage), alcoholism, epilepsy and propensity to convulsive seizures, elderly age, gout, hypertension.

Pregnancy and lactation:Acetylsalicylic acid when used in the first trimester of pregnancy has a teratogenic effect; in the III trimester leads to inhibition of labor. Stand out with breast milk, so use during lactation is contraindicated.

Dosing and Administration:

The drug should be taken more than 5 days as an analgesic drug and more than 3 days - antipyretic (without appointment and supervision by a doctor).

Inside (during or in a meal), 1 tablet every 4 hours, with pain - 1 - 2 tablets; the average daily dose - 3 - 4 tablets, the maximum daily dose - 8 tablets. The course of treatment - no more than 3-5 days.

Side effects:

Side reactions typical of acetylsalicylic acid, paracetamol and caffeine can occur: anorexia, nausea, vomiting, gastralgia, decreased platelet aggregation, erosive and ulcerative lesions of the gastrointestinal tract and duodenum, gastrointestinal bleeding, allergic reactions, bronchospasm, multiforme exudative erythema (incl.Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), renal failure, hepatic insufficiency, dizziness, tachycardia, increased blood pressure. With long-term use - headache, visual impairment, tinnitus, hypokaogulation, haemorrhagic syndrome (epistaxis, bleeding gums, purpura, etc.), kidney damage with papillary necrosis, Rhine syndrome in children.

Overdose:

Do not exceed the recommended dose and duration of use!

Symptoms:

- with mild intoxication: nausea, vomiting, stomach pain, dizziness, ringing in the ears;

- with severe intoxication: inhibition, drowsiness, collapse, convulsions, shortness of breath, anuria, bleeding.

Treatment: gastric lavage with activated charcoal, symptomatic therapy, depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate or sodium lactate, which increases the excretion of acetylsalicylic acid due to alkalinization of urine.

Interaction:

Strengthens the action of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic drugs.

Simultaneous administration with other non-steroidal anti-inflammatory drugs, methotrexate increases the risk of side effects.

Reduces the effectiveness of pyrones from lacto, furosemide, hypotensive drugs, as well as proizvodivograficheskih drugs that promote the excretion of uric acid.

Barbiturates, rifampicin. salicylamide, antiepileptic drugs and other stimulants of microsomal oxidation contribute to the formation of toxic metabolites of paracetamol that affect liver function.

Metoclopramide accelerates the absorption of paracetamol.

Under the influence of paracetamol, the time of chloramphenicol elimination is increased by 5 times. At repeated reception paracetamol can enhance the effect of anti-coagulum i yigo in (dicumarin derivatives). Caffeine accelerates the absorption of ergotamine.

With the simultaneous administration of the drug and alcohol-containing liquids, the risk of toxic damage to the liver increases.

Special instructions:

Do not prescribe the drug to children under 15 due to the high risk of developing the syndrome. Reye's syndrome is manifested by prolonged vomiting, acute encephalopathy, enlargement of the liver.

Acetylsalicylic acid slows blood clotting. If the patient is to undergo surgery, a doctor should be warned in advance about taking the drug.

In patients with a predisposition to the accumulation of uric acid, taking the drug may trigger a gout attack.

During the intake should refrain from drinking alcohol (increased risk of gastrointestinal bleeding and toxic damage to the liver).

Form release / dosage:Pills.

Packaging:

For 6 or 10 tablets in a contiguous cell-free or cell pack.

1,2, 3 or 5 contour cell packs along with the instruction for use are placed in a bundle. It is allowed to place contiguous mesh and non-jawed packages in a group package.

Storage conditions:Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life:

4 years. The drug should be used before the date indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N000499 / 01

Date of registration:04.08.2010

The owner of the registration certificate:PHARMSTANDART-FORESTRY, OJSC PHARMSTANDART-FORESTRY, OJSC Russia

Manufacturer: & nbsp

PHARMSTANDART-FORESTRY, OJSC Russia

Information update date: & nbsp18.03.2013

Illustrated instructions

Instructions

Citramon P (Citramon P)