Kofitsil-plus - instructions for use, doses, side effects, contraindications

Excipients: potato starch - 0.1265 g talc - 0.00982 g of stearic acid - 0.0060 g Povidone - 0.00458 g magnesium stearate - 0.0013 g Colloidal silica - 0.0009 g, methylcellulose - 0 , 0009

Description:Tablets from white to white with a pinkish hue of color, flat-cylindrical, with a facet and a risk. A slight smell and marbling on the surface of the tablets is allowed.

Pharmacotherapeutic group:Analgesic agent (analgesic non-narcotic remedy + psychostimulant + non-steroidal anti-inflammatory drug)

ATX: & nbsp

N.02.B.A.51 Acetylsalicylic acid in combination with other drugs, excluding psycholeptics

Pharmacodynamics:

Combined drug, the effect of which is determined by the components that make up its composition.

Acetylsalicylic acid has an analgesic, antipyretic, anti-inflammatory effect associated with the suppression of cyclooxygenases 1 and 2 regulating the synthesis of prostaglandins; inhibits the aggregation of platelets.

Caffeine increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, dilates the blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces drowsiness, a feeling of fatigue, increases mental and physical performance. Paracetamol has antipyretic, analgesic effect.

Indications:

Kofitsil-plus is used in adults with mild to moderate pain syndrome (headache, toothache, neuralgia, myalgia, thoracic radicular syndrome, lumbago, arthralgia, algodismenorea, migraine), in adults and children older than 15 years to reduce fever, with "colds" and other infectious inflammatory diseases.

Contraindications:

- Hypersensitivity to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (NSAIDs) and xanthines;

- erosive and ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation);

- marked violations of the liver or kidney;

- "aspirin asthma";

- hemorrhagic diathesis (von Willebrand's disease, hemophilia, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura);

- exfoliating aortic aneurysm;

- deficiency of glucose-6-phosphate dehydrogenase;

- portal hypertension, vitamin K deficiency;

- anxiety disorders (agoraphobia, panic disorder);

- organic diseases of the cardiovascular system (acute myocardial infarction, arterial hypertension, paroxysmal tachycardia, frequent ventricular extrasystole);

- glaucoma;

- surgical interventions accompanied by bleeding.

The drug is not prescribed as an anesthetic for people under 18 years old, as an antipyretic agent - children under 15 years with acute respiratory diseases caused by viral infections because of the danger of developing Reye syndrome (encephalopathy and acute fatty liver with acute development of liver failure.

Carefully:Hyperuricemia, urate nephrolithiasis, gout, peptic ulcer and / or duodenal ulcer (in the anamnesis), decompensated heart failure.

Pregnancy and lactation:

Contraindicated in pregnancy during the I and III trimester, in the second trimester of pregnancy, one-time intake of the drug at recommended doses is possible only if the expected benefit for the mother does not exceed the potential risk to the fetus.

If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Dosing and Administration:

The drug is used inside after eating 1 -2 tablets 2-3 times a day. The maximum daily dose is 6 tablets. The interval between doses should be at least 4 hours. To reduce the irritant effect on the gastrointestinal tract, the drug should be taken after meals, washed down with water, milk, alkaline mineral water.

If there is a violation of the kidney or liver function, the break between doses is not less than 6 hours.

The drug should not be taken more than 5 days with an appointment as an anesthetic and more than 3 days as an antipyretic.Other dosages and regimens are prescribed by the doctor.

Side effects:

Anorexia, nausea, vomiting, gastralgia, diarrhea, erosive-ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, hepatic and / or renal insufficiency, increased blood pressure, tachycardia.

Allergic reactions: skin rash, Quincke's edema, bronchospasm.

With prolonged use - dizziness, headache, visual disturbances, tinnitus, reduced platelet aggregation, hypocoagulation, hemorrhagic syndrome (epistaxis, bleeding gums, purpura, etc.), kidney damage with papillary necrosis; deafness; Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), Reye's syndrome in children (metabolic acidosis disorders of the nervous system and psyche, vomiting, liver dysfunction).

Overdose:

Nausea, vomiting, pain in the stomach, sweating, pallor of the skin, tachycardia. With light intoxication - ringing in the ears; severe intoxication - incoherent thinking, drowsiness, collapse, convulsions, bronchospasm, shortness of breath, anuria, bleeding.As the intoxication intensifies, progressive paralysis of respiration and dissociation of oxidative phosphorylation cause respiratory acidosis.

If you suspect a poisoning, you should immediately seek medical help.

Treatment: the affected person should rinse the stomach and prescribe adsorbents (Activated carbon).

Interaction:

Enhances the effect of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, anti-arthritis agents that promote the excretion of uric acid.

Increases the side effects of glucocorticosteroids, sulfonylureas, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

Avoid combination of the drug with barbiturates, antiepileptics, zidovudine, rifampicin and alcohol containing beverages (increases the risk of hepatotoxic effect).

Under the influence of paracetamol, the time of chloramphenicol elimination is increased by 5 times. Caffeine accelerates the absorption of ergotamine.

Special instructions:

When the drug is used for a long time, the control of peripheral blood and the functional state of the liver is necessary. Because the acetylsalicylic acid has an antiaggregatory effect, the patient, if he is to undergo surgery, should warn the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid. This can in some cases provoke a gout attack.

During treatment, you should stop using alcohol containing drinks (increased risk of gastrointestinal bleeding).

Acetylsalicylic acid has a teratogenic effect: when applied in the first trimester of pregnancy leads to malformations - the cleavage of the upper palate; in the third trimester - inhibition of labor (inhibition of the synthesis of prostaglandins), the closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circulation. Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the child due to impaired platelet function.

Effect on the ability to drive transp. cf. and fur:

During treatment should be abandoned the employment of potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:

Tablets 300 mg + 50 mg + 100 mg.

Packaging:

For 6 or 10 tablets in a contour cell or cell-free packaging without attachment to a pack of cardboard.

For 500 contour mesh or cellless packages together with an equal number of instructions for use in a cardboard box for consumer packaging (for inpatient).

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002640

Date of registration:07.03.2012

Expiration Date:Unlimited

The owner of the registration certificate:Barnaul Plant of Medical Preparations, LLC Barnaul Plant of Medical Preparations, LLC Russia

Manufacturer: & nbsp

Barnaul Plant of Medical Preparations, LLC Russia

Information update date: & nbsp21.01.2018

Illustrated instructions

Instructions

Kofitsil-plus (Coficil-plus)