- Stomach ulcer and duodenal ulcer in the phase of exacerbation;
- Gastrointestinal bleeding (including in the anamnesis);
- Pronounced violations of the liver and / or kidney function, gout;
- Hemorrhagic diathesis, hypocoagulation, hypoprothrombinemia;
- Surgical interventions accompanied by heavy bleeding;
- Deficiency of glucose-6-phosphate dehydrogenase;
- Glaucoma;
- Hypersensitivity to the drug components, intolerance to acetylsalicylic acid, bronchial asthma, induced by the use of acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs, polyposis of the nose;
- Children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases);
- Increased excitability, sleep disturbance;
- Organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis);
- Arterial hypertension;
- Portal hypertension;
- Avitaminosis K.