Citramon P - instructions for use, dose, side effects, contraindications

Acetylsalicylic acid has antipyretic and anti-inflammatory effect, relieves pain,especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and thrombus formation, improves microcirculation in the inflammatory focus.

Caffeine increases the excitability of spinal cord reflex, excites the respiratory and vasomotor centers, dilates blood vessels in skeletal muscle, brain, heart, kidneys, reducing platelet aggregation; reduces drowsiness, fatigue. In this combination caffeine in a small dose practically does not stimulatethe effect on the central nervous system, but it contributes to the regulation of the tone of the vessels of the brain.

Paracetamol has analgesic, antipyretic and weak anti-inflammatory effects, which is associated with its influence on the center of thermoregulation in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins (Pg) in peripheral tissues.

Indications:

Pain syndrome of mild and moderate severity (of various origins): headache, migraine, toothache, neuralgia, myalgia, arthralgia, algodismenorea. Feverish syndrome: with acute respiratory diseases (ARI), influenza.

Contraindications:

■ Stomach ulcer and duodenal ulcer in the phase of exacerbation;

■ Gastrointestinal hemorrhage (including in the anamnesis);

■ Pronounced violations of the liver and / or kidney function, gout;

■ Hemorrhagic diathesis, hypocoagulation;

■ Surgical interventions accompanied by heavy bleeding;

■ Pregnancy (I and III trimester), lactation period;

■ Deficiency of glucose-6-phosphate dehydrogenase;

■ Glaucoma;

■ Hypersensitivity to the components of the drug, asthma, induced by the use of acetylsalicylic acid, salicylates and other non-steroidal anti-inflammatory drugs;

■ Children's age (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia on the background of viral diseases);

■ Increased excitability, sleep disturbance;

■ Organic diseases of the cardiovascular system (including acute myocardial infarction, atherosclerosis);

■ Severe arterial hypertension

■ Portal hypertension

■ Avitaminosis To

■ Hypoproteinemia

Carefully:

Renal failure of mild to moderate degree, liver failure with increased transaminase levels, benign hyperbilirubinemia (incl.Gilbert syndrome, alcoholic liver disease), alcoholism, epilepsy and susceptibility to seizures, advanced age, gout, hypertension.

Pregnancy and lactation:

Acetylsalicylic acid when used in the first trimester of pregnancy has a teratogenic effect; in the third trimester - to inhibition of labor. It is excreted in breast milk, therefore it is contraindicated during lactation.

Dosing and Administration:

The drug should not be taken more than 5 days as an analgesic drug and more than 3 days - antipyretic (without appointment and supervision of a doctor).

Inside (during or after a meal), 1 tablet every 4 hours, with pain - 1 - 2 tablets; the average daily dose - 3 - 4 tablets, the maximum daily dose - 8 tablets. The course of treatment - no more than 3-5 days.

Side effects:May experience adverse reactions that are typical of acetylsalicylic acid, acetaminophen and caffeine: anorexia, nausea, gastralgia, decrease platelet aggregation, erosive and ulcerative lesions of the gastrointestinal tract, the duodenum, gastrointestinal haemorrhage, allergic response, bronchoconstriction, multiform exudative erythema (incl.Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), renal failure, hepatic insufficiency, dizziness, tachycardia, increased blood pressure. With prolonged use - headache, visual impairment, tinnitus, hypocoagulation, hemorrhagic syndrome (epistaxis, bleeding gums, purpura, etc.), kidney damage with papillary necrosis, Rhine syndrome in children.

Overdose:

Do not exceed the recommended dose and duration of use!

Symptoms:

- with mild intoxication: nausea, vomiting, stomach pain, dizziness, ringing in the ears;

- with severe intoxication: retardation, drowsiness, collapse, convulsions, shortness of breath, anuria, bleeding.

Treatment: gastric lavage with activated charcoal, symptomatic therapy, depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate or sodium lactate, which increases the excretion of acetylsalicylic acid due to alkalinization of urine.

Interaction:

Strengthens the action of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic drugs.

Simultaneous administration with other non-steroidal anti-inflammatory drugs, methotrexate increases the risk of side effects.

Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, as well as anti-arthritis drugs that promote the excretion of uric acid.

Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other stimulants of microsomal oxidation contribute to the formation of toxic metabolites of paracetamol that affect liver function.

Metoclopramide accelerates the absorption of paracetamol.

Under the influence of paracetamol, the half-life of chloramphenicol increases five-fold. At repeated reception paracetamol can enhance the effect of anticoagulants (derivatives of dicumarin). Caffeine accelerates the absorption of ergotamine.

With the simultaneous administration of the drug and alcohol-containing liquids, the risk of toxic damage to the liver increases.

Special instructions:

Do not prescribe the drug to children under 15 due to the high risk of developing Reye's syndrome. Reye's syndrome is manifested by prolonged vomiting, acute encephalopathy, enlargement of the liver.

Acetylsalicylic acid slows blood clotting. If the patient is to undergo surgery, a doctor should be warned in advance about taking the drug.

In patients with a predisposition to the accumulation of uric acid, taking the drug may trigger a gout attack.

During the intake should refrain from drinking alcohol (increased risk of gastrointestinal bleeding and toxic damage to the liver).

Effect on the ability to drive transp. cf. and fur:not described

Form release / dosage:

Pills.

Packaging:

6 or 10 tablets per circuit gluten-free packaging.

10 tablets per contour cellforging.

1 or 2 contour mesh or junk Packaging with instructionsdicin use is placed in a pack from cardboard.

Contourless gluten-free packaging together with an equal number of instructions for medical use are placed in a group package.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years. The drug should be used before the date indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-000021

Date of registration:28.03.2007

The owner of the registration certificate:PHARMSTANDART-TOMSKHIMFARM, OJSC PHARMSTANDART-TOMSKHIMFARM, OJSC Russia

Manufacturer: & nbsp

PHARMSTANDART-TOMSKHIMFARM, OJSC Russia

Information update date: & nbsp11.05.2012

Illustrated instructions

Instructions

Citramon P (Citramon P)