Active substanceHydroxymethylquinoxaline dioxideHydroxymethylquinoxaline dioxide
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  • Dosage form: & nbspSolution for intravenous administration.
    Composition:
    1 ml of the preparation contains: active substance 5 mg of dioxidine (hydroxymethylquinoxylindioxide), auxiliaries water for injections up to 1ml.
    Description:
    Light yellow with a greenish shade of clear liquid.
    Pharmacotherapeutic group:antimicrobial agent - quinoxaline
    ATX: & nbsp

    J.01.X.X   Other antibacterial drugs

    Pharmacodynamics:
    Antibacterial preparation of a broad spectrum of action from the group of quinoxaline derivatives, has chemotherapeutic activity in infections,caused by vulgar proteus, dysenteric rod, Klebsiella, Pseudomonas aeruginosa, salmonella, staphylococcus, streptococcus, pathogenic anaerobes (including pathogens of gas gangrene), acts on strains of bacteria resistant to other chemotherapies, including antibiotics.
    Possible development of drug resistance of bacteria. At intravenous introduction is characterized by small therapeutic breadth, in this connection strict observance of recommended doses is necessary.
    Pharmacokinetics:
    After intravenous administration, the therapeutic concentration of the drug in the blood persists for 4-6 hours. Good and quickly penetrates into all organs and tissues, is excreted by the kidneys. With repeated administration does not cumulate.
    Indications:
    Purulent bacterial infections caused by sensitive microflora when other chemotherapeutic agents are ineffective or poorly tolerated.
    Severe septic conditions (including patients with burn disease), purulent meningitis, severe purulent-inflammatory processes with symptoms of infection generalization.
    Contraindications:
    Increased sensitivity to dioxin, adrenal insufficiency (including in history), pregnancy, lactation,childhood.
    Carefully:Renal failure.
    Dosing and Administration:
    Intravenously. A 0.5% solution of the drug is injected into the vein, which is diluted with 5% dextrose solution or 0.9% sodium chloride solution isotonic to a concentration of 0.1-0.2%. The daily dose of the drug is administered once or in 3-4 divided doses (fractional administration). The drug is administered at a rate of 60-80 drops per minute for 30 minutes.
    Recommended doses of the preparation depending on the localization of the process:
    1. In the treatment of a purulent urinary tract infection, a daily dose of 200-400 mg of dioxidine, i.e. 40-80 ml of 0.5% solution;
    2. In chronic purulent processes in the lungs, the daily dose of 500-600 mg of dioxidine, i.e. 100-120 ml of 0.5% solution.
    3. With pustular meningitis, the daily dose of 600-700 mg of dioxidine, i.e. 120-140 ml of 0.5% solution.
    4. In severe septic conditions, a 0.5% solution of the drug is injected intravenously intravenously, which is diluted in a 5% solution of dextrose or 0.9% solution of sodium chloride isotonic to a concentration of 0.1-0.2%. The daily dose of 600-900 mg (3-4 times).
    Side effects:With intravenous administration, headache, chills, fever, dyspeptic disorders, convulsive muscle contractions,allergic reactions, photosensitizing effect (the appearance of pigmented spots on the body when exposed to sunlight).
    Special instructions:
    In chronic renal failure, the dose is reduced. Assign only with ineffectiveness of other antibacterial drugs, including cephalosporins II-IV generations, fluoroquinolones, carbapenems.
    When pigmented spots appear, the duration of administration of a single dose is increased to 1.5-2 hours, the dose is reduced, antihistamines are prescribed, or dioxygen is canceled.
    Form release / dosage:Solution for intravenous administration 5 mg / ml.
    Packaging:Ampules of 5 and 10 ml. 10 ampoules together with the instructions for use and the ampoule ampullum in a cardboard box.
    Storage conditions:
    List B. In the dark place at a temperature of 18 to 25 ° C.
    Keep out of the reach of children.
    Shelf life:3 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:P N000806 / 01
    Date of registration:19.11.2007
    The owner of the registration certificate:MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.12.2015
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