Intravenously.
Slowly drip.
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Introduce a solution of the drug 5 mg / ml, which is previously diluted in a 5% solution of dextrose or in a 0.9% solution of sodium chloride to a concentration of hydroxymethylquinoxaline dioxide 1-2 mg / ml.The daily dose of the drug is administered once or in 3-4 divided doses. The drug is administered at a rate of 60-80 drops / min for 30 minutes.
In severe septic states the maximum single dose is 300 mg (corresponding to 60 ml hydroxymethylquinoxaline dioxide solution 5 mg / ml), the daily dose is 600 mg (120 ml hydroxymethylquinoxaline dioxide solution 5 mg / ml).
With purulent meningitis The daily dose is 600 mg of hydroxymethylquinoxaline dioxide (ie 120 ml of a solution of 5 mg / ml).
In chronic purulent processes in the lungs in the acute stage with signs of generalization The daily dose is 500-600 mg of the drug (that is, 100-120 ml of a solution of 5 mg / ml).
When treating a severe purulent urinary tract infection The daily dose is 200-400 mg of hydroxymethylquinoxaline dioxide (ie 40-80 ml of a solution of 5 mg / ml).
For patients with impaired renal function the dose of the drug is reduced by half.
When applying in elderly patients should take into account the possible age-related decline in kidney function, which should also be taken into account in determining the therapeutic dose.
It is necessary to strictly observe the recommended doses, not allowing their excess, since the drug has a narrow therapeutic breadth.
In the case of precipitation of crystals of hydroxymethylquinoxaline dioxide, the crystals are dissolved in ampoules with a solution, heating ampoules in a boiling water bath with shaking until the crystals dissolve completely (the solution should become transparent). If the crystals do not drop again when the ampoules with the drug are cooled to 36-38 ° C, the preparation is suitable for use.