Dioxydin® (Dioxydin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceHydroxymethylquinoxaline dioxideHydroxymethylquinoxaline dioxide
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    • Dosage form: & nbspsolution for infusion and external use
    Composition:Active substance: hydroxymethylquinoxaline dioxide (dioxidin) - 5 mg.
    Excipient: water for injection - up to 1 ml
    Description:Transparent greenish-yellow liquid.
    Pharmacotherapeutic group:antimicrobial agents, quinoxaline derivatives
    ATX: & nbsp

    J.01.X.X   Other antibacterial drugs

    Pharmacodynamics:
    Antibacterial bactericidal preparation of a wide spectrum of action. It is active against Proteus vulgaris, Pseudomonas aeruginosa, Klebciella pneumoniae, Escherichia coli, Shigella dysenteriae, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp., Staphylococcus spp., Streptococcus spp.,
    pathogenic anaerobes (Clostridium perfringens). It acts on strains of bacteria resistant to other antimicrobial medicines, including antibiotics. Does not have a local irritant effect. Possible development of drug resistance of bacteria. At intravenous introduction is characterized by small therapeutic breadth, in this connection, strict observance of recommended doses is necessary. Treatment of burns and purulent-necrotic wounds promotes faster cleaning of the wound surface, stimulates reparative regeneration and marginal epithelization and favorably influences the course of the wound process.
    In experimental studies, the presence of teratogenic, embryotoxic and mutagenic effects was demonstrated.
    Pharmacokinetics:After intravenous administration, the therapeutic concentration in the blood remains 4-6 hours TCmax in the blood - 1-2 hours after a single injection. Good and quickly penetrates into all organs and tissues, is excreted by the kidneys. With repeated administration does not cumulate.
    Indications:
    Intravenously: septic conditions (including in patients with burn disease), purulent meningitis, purulent-inflammatory processes with symptoms of generalization.
    Locally: wound and burn infection (superficial and deep purulent wounds of various locations, long-term healing wounds and trophic ulcers, soft tissue phlegmon, infected burns, purulent wounds in osteomyelitis), pustular skin diseases.
    Contraindications:Hypersensitivity, adrenal insufficiency (including in the anamnesis), children's age (to 18 years).
    Carefully:Renal failure.
    Pregnancy and lactation:During pregnancy and during breastfeeding, Dioxydin is contraindicated.
    Dosing and Administration:
    Intravenous - drip. In severe septic conditions, the solution is administered, previously diluted in a 5% solution of dextrose or in a 0.9% solution of sodium chloride to a concentration of 0.1-0.2%. The highest single dose is 300 mg, the daily dose is 600 mg.
    Outer - deep wounds are plugged or irrigation is carried out every day or every other day, depending on the condition of the burn wound and the course of the wound process. The maximum daily dose is 2.5 g. The duration of treatment is up to 3 weeks.
    Side effects:
    Allergic reactions. After intravenous administration, headache, chills, hyperthermia, nausea, vomiting, diarrhea,muscle twitching, photosensitizing effect.
    Local reactions: paranasal dermatitis, itching.
    Overdose:With an overdose of Dioxydin, the development of acute adrenal insufficiency is possible, which requires immediate withdrawal of the drug and appropriate hormone replacement therapy.
    Interaction:With increased sensitivity to the drug, Dioxydin is used concomitantly with antihistamines or calcium preparations.
    Special instructions:
    Dioxydin is prescribed only in severe forms of infectious diseases or in the ineffectiveness of other antibacterial drugs, including cephalosporins of II-IV generations, fluoroquinolones, carbapenems.
    In chronic renal failure, the dose is reduced.
    In the case of crystal precipitation during storage (at temperatures below 15 ° C), they are dissolved by heating the ampoules in a boiling water bath with shaking until the crystals are completely dissolved (clear solution). If the crystals do not fall again upon cooling to 36 - 38 ° C, the preparation is usable.
    Effect on the ability to drive transp. cf. and fur:During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities,requiring increased concentration of attention and speed of psychomotor reactions.
    Form release / dosage:

    Solution for infusion and external use 5 mg / ml.

    Packaging:
    5 ml or 10 ml into neutral glass ampoules.
    By 3, 5 or 10 ampoules are placed in a contour mesh package made of a polyvinyl chloride film or tapes
    polyethylene terephthalate and aluminum foil or paper with polyethylene coating or without foil, or without paper.
    For 1 or 2 contour packs with instructions for use and a knife for opening ampoules or a scarifier ampullum is placed in a pack of cardboard.
    When you pack the ampoules with a break ring or break point, the ampoule opener or ampoule scapper is not put in.
    Storage conditions:
    In the dark place at a temperature of 15 to 25 ° C.
    Keep out of the reach of children.
    Shelf life:
    2 years.
    Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:LP-001038
    Date of registration:21.10.2011
    The owner of the registration certificate:VALENTA PHARM, PAO VALENTA PHARM, PAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp12.12.2015
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