Intravenous administration
Intravenously drip (at a speed of 60-80 drops per minute) under the supervision of a doctor. Enter a solution of 5 mg / ml, which is previously diluted in a 5% solution of dextrose (glucose) or in a 0.9% solution of sodium chloride to a concentration of 1-2 mg / ml (0.1-0.2%).
The daily dose the drug is administered once or in 3-4 times during the day (fractional administration). The drug is administered at a rate of 60-80 drops / min for 30 minutes.
In severe septic conditions the maximum single dose is 300 mg (60 ml of a solution of 5 mg / ml), the daily dose is 600 mg of hydroxymethylquinoxaline dioxide (ie 120 ml of a solution of 5 mg / ml).
With purulent meningitis daily dose of 600 mg of hydroxymethylquinoxaline dioxide (that is, 120 ml of a solution of 5 mg / ml).
In chronic purulent processes in the lungs in the stage of exacerbation with signs of generalization daily dose of 500-600 mg of hydroxymethylquinoxaline dioxide (that is, 100-120 ml of a solution of 5 mg / ml).
When treating a severe purulent urinary tract infectionth day dose - 200-400 mg of hydroxymethylquinoxaline dioxide (ie 40-80 ml of a solution of 5 mg / ml).
For patients with impaired renal function the dose of the drug is reduced by 2 times.
In elderly patients it may be necessary to reduce the dose in the event of a violation of kidney function.
In the case of precipitation of crystals of hydroxymethylquinoxaline dioxide, the crystals are dissolved in ampoules with a solution, heating ampoules in a boiling water bath with shaking until the crystals dissolve completely (the solution should become transparent). If the crystals do not drop again when the ampoules with the drug are cooled to 36-38 ° C, the preparation is suitable for use.
Local and external use
Apply 1-5 mg / ml solutions of hydroxymethylquinoxaline dioxide. To obtain a solution of the desired concentration, the drug is diluted with a sterile 0.9% solution of sodium chloride or water for injection.
For the treatment of superficial purulent wounds on the wound surface, previously cleaned from purulent-necrotic masses, apply napkins moistened with a solution of the drug. Bandages are changed daily or every other day, depending on the condition of the wound or the course of the wound process.
Deep Wounds after treatment loosely tamponized with tampons moistened with the drug solution. Dressings are done once a day.
The maximum daily dose of hydroxymethylquinoxaline dioxide is 2.5 g (500 ml of a solution of 5 mg / ml). Duration of treatment - up to 3 weeks.
For the treatment of deep purulent wounds in osteomyelitis (wounds of the hand, feet) apply a solution of the drug in the form of trays or special treatment of the wound with the drug for 15-20 minutes (insertion of the solution into the wound at this time), followed by the application of dressings moistened with a solution.
For long-term washing of wounds Apply a solution of hydroxymethylquinoxaline dioxide 1 mg / ml (draining the wound with a thin catheter, rinsing with a few drops for 3-4 hours 1-2 times a day, but not more than 400-500 ml of solution for rinsing).
To prevent infections after surgery 1-2 mg / ml solutions of the drug are used.
According to the indications (patients with osteomyelitis) and with good tolerability, treatment can be carried out daily for 1.5-2 months.
In the case of precipitation of crystals of hydroxymethylquinoxaline dioxide, the crystals are dissolved in ampoules with a solution, heating ampoules in a boiling water bath with shaking until the crystals dissolve completely (the solution should become transparent). If the crystals do not drop again when the ampoules with the drug are cooled to 36-38 ° C, the preparation is suitable for use.