Furagin-LekT tablets 50 mg - instructions for use, dose, side effects, contraindications

Excipients: potato starch - 20 mg, lactose monohydrate (milk sugar) - 18.8 mg, granulated sugar - 10 mg, polysorbate-80 (Tween 80) - 0.2 mg, calcium stearate - 1.0 mg.

Description:

Tablets from yellow to yellow - with an orange shade of color, a flat-cylindrical shape

Pharmacotherapeutic group:antimicrobial agent - nitrofuran

ATX: & nbsp

D.08.A.F Nitrofuran derivatives

J.01.X.E Nitrofuran derivatives

Pharmacodynamics:

Effective against gram-positive cocci.(Staphylococcus spp., Streptococcus spp.), Gram-negative rods (E. coli, Salmonella spp., Shigella spp., Klebsiella spp.). Stable Plasmodium, aeruginosa, Enterococcus spp., Acinetobacter spp., most strains Proteus spp., Serratia spp. The mechanism of action is related to the inhibition of the synthesis of nucleic acids. Depending on the concentration has a bactericidal or bacteriostatic effect. Against most bacteria, the bacteriostatic concentration ranges from 10-20 μg / ml. The bactericidal concentration is approximately 2 times higher. Under the influence of nitrofurans in microorganisms, the activity of the respiratory chain and the cycle of tricarboxylic acids (Krebs cycle) is suppressed, as well as the inhibition of other biochemical processes, which leads to the destruction of their membrane or cytoplasmic membrane.

Pharmacokinetics:

Absorbed in the distal segment of the intestine by passive diffusion. It is excreted by the kidneys (6%), creating in the urine concentrations many times higher than bacteriostatic (maximum concentration Сmах in urine-5.7 μg / ml).

Indications:

Apply inside. Inside is prescribed mainly for infectious diseases of the kidneys and urinary tract (acute and chronic pyelonephritis, cystitis, urethritis, infections after surgery) and sometimes with infectious and inflammatory diseases of the respiratory tract.

Contraindications:

hypersensitivity to furazidine, other components of the drug;
kidney failure;
deficiency of lactose, sucrose / isomaltase, lactose intolerance, fructose, glucose-galactose malabsorption;
children's age till 18 years; .
pregnancy: the period between the 38th and 42nd weeks;
lactation period

Carefully:

Chronic renal failure, deficiency of glucose-6-phosphate dehydrogenase, diseases of the liver and nervous system.

Caution should be given Furazidine patients with diabetes mellitus. on the background of the drug may appear symptoms of polyneuropathy.

Pregnancy and lactation:

The use of furazidine is contraindicated between the 38th and 42nd weeks of pregnancy and during lactation.

Dosing and Administration:

Furazidine is applied inside, after eating. For treatment, apply in a dose of 0.05-0.1 g. 3 times a day for 7-10 days. If necessary, after 10 - 15 days, break courses of treatment are repeated. To prevent infections in urological operations, cystoscopy, catheterization apply once 0.05 g for 30 minutes. before surgery or manipulation.

Edit Warnings

In case of impaired renal function furazidine apply in reduced doses.

Side effects:

In a certain category of patients, taking the drug, as well as any other medicinal compounds, can lead to the development of adverse reactions.

It can be:

anorexia;
decreased appetite;
nausea;
vomiting;
dizziness;
allergic reactions (skin rash, enanthema, angioedema, swelling of the joints, itching):

At the expressed by-effects the further reception of a preparation stop. Inform the attending physician about any unwanted or unpleasant reactions or feelings that are not included in this list.

Overdose:

Symptoms: neurotoxic reactions, including ataxia, tremor.

Treatment: drug withdrawal, large amounts of fluid intake, symptomatic therapy, antihistamines, B group vitamins. There is no specific antidote.

Interaction:

Inform the doctor about any medications you take. With the simultaneous application of furazidine and nalidixic acid, a decrease in the bacteriostatic effect of furazidine is noted.

When used simultaneously with uricosuric drugs (probenecid, sulfinpyrazone).decreases the excretion of furazidine in the urine, which leads to a decrease in its therapeutic effectiveness. This can lead to the accumulation of furazidine in the body and increase the toxicity of the drug.

With simultaneous application of furazidine and antacids containing magnesium trisilicate, absorption decreases.

Do not drink alcohol.

Special instructions:

To prevent the development of side effects, the drug is washed down with a large amount of liquid, and if necessary, reduce the dose and conduct desensitizing therapy. Side effects often develop in patients with decreased renal excretory function. During prolonged treatment with the drug should periodically monitor the level of leukocytes in the blood, as well as indicators of liver and kidney function.

Effect on the ability to drive transp. cf. and fur:

The use of furazidine is contraindicated between the 38th and 42nd weeks of pregnancy and during lactation.

Form release / dosage:

Tablets 50 mg.

Packaging:

10 tablets per contour cell pack. By. 10 tablets in a contour non-jawed package. For 30 tablets in cans, such as BDS or jars of low pressure polyethylene.Each jar or 3 contour packs, together with the instruction for use, is placed in pack.

Storage conditions:

Store in a dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LP-001227

Date of registration:16.11.2011

The owner of the registration certificate:Tyumen Chemical - Pharmaceutical Plant, OJSC Tyumen Chemical - Pharmaceutical Plant, OJSC Russia

Manufacturer: & nbsp

Tyumen Chemical - Pharmaceutical Plant, OJSC Russia

Information update date: & nbsp11.11.2015

Illustrated instructions

Instructions

Furagin-lekT tablets 50 mg (Furagin-LekT)