Furagin - instructions for use, dose, side effects, contraindications

Excipients: lactose monohydrate (sugar milk) - 36.0 mg, potato starch - 7.0 mg, croscarmellose sodium 2.0 mg, povidone (polyvinylpyrrolidone) 4.0 mg, magnesium stearate 1.0 mg.

Description:

Tablets from yellow to yellow with orange shade of color, flat-cylindrical shape, with a facet on both sides and risk from one side.

Pharmacotherapeutic group:antimicrobial agent, nitrofuran

ATX: & nbsp

D.08.A.F Nitrofuran derivatives

J.01.X.E Nitrofuran derivatives

Pharmacodynamics:

Antimicrobial agent, a derivative of nitrofuran.Effective against gram-positive cocci (Staphylococcus spp., Streptococcus spp.), Gram-negative rods (Escherichia coli, Salmonella spp., Shigella spp, Klebsiella spp.). Stable Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp., most strains Proteus spp., Serratia spp. Furazidine is reduced by bacterial flavoproteins to active compounds that inactivate or damage proteins of bacterial ribosomes and other macromolecules. As a result, aerobic respiration and the processes of protein, cell wall, DNA and RNA synthesis are violated. The multiple mechanism of action explains the weak acquired resistance of microorganisms to nitrofurans. Depending on the concentration has a bactericidal or bacteriostatic effect. Against most bacteria, the bacteriostatic concentration ranges from 10-20 μg / ml. The bactericidal concentration is approximately 2 times higher. As a result of the action of nitrofurans, microorganisms produce fewer toxins, so that an improvement in the general condition of the patient is possible even before the expressed suppression of microflora growth.

Pharmacokinetics:

Absorption in the small intestine, by passive diffusion. Absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segment by 2 and 4 timesrespectively (should be considered when treating diseases of the urinary tract in combination with diseases of the gastrointestinal tract, including chronic enteritis). Poorly absorbed in the large intestine. It is distributed evenly. High concentrations are found in lymph; in bile its concentration is several times higher than in serum, in cerebrospinal fluid - several times lower than in serum; saliva contains up to 30% of its serum concentration; in the blood and tissues the concentration is small, which is associated with its rapid elimination, while its concentration in the urine is much higher than in the blood. The maximum concentration (Stach) in the serum remains from 3 to 7-8 hours, in urine is detected after 3-4 hours. Does not change the pH of urine, in contrast to nitrofurantoin. Metabolised in the liver (less than 10%), with a decrease in excretory function of the kidneys, the intensity of metabolism increases. It is excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially subjected to reverse reabsorption in tubules. At low concentrations in the urine, the process of filtration and secretion predominates, at high concentrations the secretion decreases and reabsorption increases.Being a weak acid does not dissociate at acidic urine pH values, it undergoes intensive reabsorption, which can exacerbate systemic side effects.

Indications:

Infectious and inflammatory diseases: urinary tract (cystitis, urethritis, pyelonephritis); infection of female genital organs; prevention of infections in urological operations, cystoscopy, catheterization.

Contraindications:

Pregnancy;
lactation;
hypersensitivity to nitrofuran derivatives;
impaired renal function;
abnormal liver function;

deficiency of lactase, lactose intolerance, glucose-galactose malabsorption;
childhood.

Carefully:

Deficiency of glucose-6-phosphate dehydrogenase;

diseases of the nervous system.

Dosing and Administration:

Furagin taken internally - 50-100 mg 3 times a day for 7-10 days.

If necessary, you can re-treat after 10-15 days.

To prevent infections in urological operations, cystoscopy, catheterization, apply once 0.05 g for 30 minutes. before surgery or manipulation.

Side effects:

Possible: dyspeptic manifestations - nausea, vomiting, decreased appetite.

From the side of the central nervous system: dizziness, headache, development of polyneuritis.

Violation of the functions of the liver.

Allergic reactions: urticaria, skin itching.

Overdose:

Symptoms: neurotoxic reactions, polyneuritis, impaired liver function, acute toxic hepatitis.

Treatment: cancellation of Furagin, administration of a large amount of fluid, symptomatic therapy, vitamins of group B. There is no specific antidote.

Interaction:

Simultaneous use with ristomycin, chloramphenicol, sulfonamides increases the risk of hematotoxic action. It should avoid the simultaneous use of other derivatives of nitrofuran, as well as drugs "acidifying" urine (incl. ascorbic acid, calcium chloride). Ethanol can increase the severity of side effects.

Special instructions:

To prevent side effects, drink plenty of liquids. To prevent the development of neuritis, vitamins of group B should be prescribed.

Given the possible side effects of the nervous system during the use of the drug, care must be taken when dealing with potentially hazardous activities,requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Tablets 50 mg.

Packaging:

For 10, 30 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

By 10,20, 30,40, 50 or 100 tablets into a polymer container for medicines.

One container or 1, 2, 3, 4, 5, 6, 8 or 10 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Storage conditions:

Store in a dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:PL-000218

Date of registration:16.02.2011

The owner of the registration certificate:OZONE, LLC OZONE, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp11.11.2015

Illustrated instructions

Instructions

Furagin (Furagin)