Furagin - instructions for use, dose, side effects, contraindications

Effective against gram-positive cocci (Staphylococcus spp., Streptococcus spp.), Gram-negative rods (Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp.). Stable Plasmodium aeruginosa, Enterococcus spp., Acinetobacter spp., most strains Proteus spp., Serratia spp. The mechanism of action is related to the inhibition of the synthesis of nucleic acids. Depending on the concentration has a bactericidal or bacteriostatic effect.

Against most bacteria, the bacteriostatic concentration is 10-20 μg / ml. The bactericidal concentration is approximately 2 times higher. Under the influence of nitrofurans in microorganisms, the activity of the respiratory chain and the cycle of tricarboxylic acids (Krebs cycle) is suppressed, as well as the inhibition of other biochemical processes, which leads to the destruction of their membrane or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms release less toxins, connection with which the improvement of the general condition of the patient is possible even before the expressed suppression of growth of microflora.

Nitrofurans unlike many other antimicrobial medicines not only do not depress the immune system of the body, but on the contrary, activate it (increase the complement titre and the ability of leukocytes to phagocytose microorganisms.

Pharmacokinetics:

Absorption is in the small intestine by passive diffusion.Absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segment by 2 and 4 times, respectively. Poorly absorbed in the large intestine.

It is distributed evenly. High concentrations are found in lymph; in bile its concentration is several times higher than in serum, in cerebrospinal fluid - several times lower than in serum; saliva contains up to 30 % from its concentration in the serum; in the blood and tissues the concentration is small, which is due to its rapid elimination, while its concentration in the urine is much higher than in the blood. The maximum concentration in the serum remains from 3 to 7-8 hours, in urine is detected after 3-4 hours. Does not change the pH of urine, in contrast to nitrofurantoin. Metabolised in the liver (less than 10%), with a decrease in excretory function of the kidneys, the intensity of metabolism increases.

It is excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially subjected to reverse reabsorption in tubules. At low concentrations in the urine, the process of filtration and secretion predominates, at high concentrations the secretion decreases and reabsorption increases.Being a weak acid does not dissociate, with acidic pH values of urine, undergoes intensive reabsorption, which can exacerbate systemic side effects.

Indications:

Treatment of infectious and inflammatory diseases of the urinary tract, prevention of infectious complications after surgical interventions on the organs of the genitourinary system.

Contraindications:

hypersensitivity to nitrofuran derivatives
impaired renal function
violations of the liver
pregnancy and lactation
Children under 18 years of age (for this dosage form)
deficiency of sucrose / isomaltase / lactase
intolerance to fructose / lactose
glucose-galactose malabsorption

Furagin is not recommended for prescribing urosepsis and infections of kidney parenchyma.

Carefully:

Do not use for anemia, lung diseases (especially in patients older than 65 years), diseases of the nervous system, diabetes, glucose-6-phosphate dehydrogenase deficiency, B group vitamins and folic acid.

Dosing and Administration:

Inside, after eating 100-200 mg 2-3 times a day for 7-10 days.

To prevent infections with urological operations, apply once 50 mg 30 minutes prior to surgery.

Side effects:

Possible: dyspeptic manifestations - nausea, vomiting, decreased appetite; dizziness, headache, development of polyneuritis; abnormal liver function; allergic reactions - skin rash (including papular), itching.

Overdose:

Symptoms: neurotoxic reactions, polyneuritis, impaired liver function, acute toxic hepatitis.

Treatment: cancellation of the drug, the intake of a large amount of fluid, symptomatic therapy, antihistamines, B vitamins. There is no specific antidote.

Interaction:

Ristomycin, chloramphenicol, sulfonamides - the risk of hematotoxic action. It should avoid the simultaneous use of other derivatives of nitrofuran, as well as drugs that "acidify" urine (including ascorbic acid, calcium chloride).

Ethanol can increase the severity of side effects.

Special instructions:

To prevent side effects, drink plenty of liquids.

To prevent the development of neuritis, vitamins of group B should be prescribed.

During the period of treatment, it is necessary to refrain from activities that require an increased concentration of attention and speed of psychomotor reactions.

Furagin stains urine in brown.

Form release / dosage:

Tablets of 50 mg.

Packaging:

For 10 tablets in a contour mesh package made of a polyvinyl chloride white film and aluminum foil.

For 3 contour squares, together with the instructions for use, are placed in a pack of cardboard.

Storage conditions:

For 10 tablets in a contour mesh package made of a polyvinyl chloride white film and aluminum foil.

For 3 contour squares, together with the instructions for use, are placed in a pack of cardboard.

Shelf life:

5 years. Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:П N015630 / 01

Date of registration:05.03.2009

The owner of the registration certificate:Olainfarm, AOOlainfarm, AO Latvia

Manufacturer: & nbsp

Olainfarm, AO

Representation: & nbspOLAINFARM JSC OLAINFARM JSC Latvia

Information update date: & nbsp11.11.2015

Illustrated instructions

Instructions

Furagin (Furagin)