Urofuragin - instructions for use, dose, side effects, contraindications

Effective against gram-positive cocci {Staphylococcus spp., Streptococcus spp.), of gram-bacillus sticks {Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp.). Stable Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp., most strains Proteus spp., Serratia spp. The mechanism of action is related to the inhibition of the synthesis of nucleic acids. Depending on the concentration has a bactericidal or bacteriostatic effect. Against most bacteria the bacteriostatic concentration is 10 to 20 μg / ml. The bactericidal concentration is approximately 2 times higher. Under the influence of nitrofurans in microorganisms, the activity of respiratory rate and the cycle of tricarboxylic acids (Krebs cycle) is suppressed, as well as the inhibition of other biochemical processes, which leads to the destruction of their membrane or cytoplasmic membrane.

Pharmacokinetics:

Absorption - in the small intestine, by passive diffusion. Absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segment by 2 and 4 times, respectively. Poorly absorbed in the large intestine.

It is distributed evenly. High concentrations are found in lymph; in bile its concentration is several times higher than in serum, in cerebrospinal fluid - several times lower than in serum; saliva contains up to 30% of its serum concentration; in the blood and tissues the concentration is small, which is associated with its rapid elimination, while its concentration in the urine is much higher than in the blood.The maximum concentration in the serum remains from 3 to 7-8 hours, in urine is detected after 3-4 hours. Does not change the pH of urine, in contrast to nitrofurantoin. Metabolised in the liver (less than 10%), with a decrease in excretory function of the kidneys, the intensity of metabolism increases. It is excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially subjected to reverse reabsorption in tubules. At low concentrations in the urine, the process of filtration and secretion predominates, at high concentrations the secretion decreases and reabsorption increases. Being a weak acid does not dissociate, at acidic values the pH of urine undergoes intensive reabsorption, which can strengthen the systemic side effect.

Indications:

Treatment of infectious and inflammatory diseases caused by microorganisms susceptible to furassidium, urinary tract (cystitis, urethritis, pyelonephritis). Prevention of infectious complications after surgical interventions on the organs of the genitourinary system.

Contraindications:

Hypersensitivity to furazidiyu, other components of the drug;

Hypersensitivity to nitrofuran derivatives;

Impaired renal function;

Violation of the function of the liver;

Pregnancy, the period of breastfeeding;

Children under 18 years;

Deficiency of lactase, sucrose / isomaltase, lactose intolerance, fructose, glucose-galactose malabsorption.

Furagin is not recommended for appointing urosepsis and infections of kidney parenchyma.

Carefully:

With anemia, lung diseases (especially in patients older than 65 years), diseases of the nervous system, diabetes mellitus, porphyria, deficiency of glucose-6-phosphate dehydrogenase, B group vitamins and folic acid.

Dosing and Administration:

Inside, after eating.

For treatment, apply 100-200 mg 2-3 times a day for 7-10 days. If necessary, after a 10-15-day break, the course of treatment is repeated. The maximum daily dose is 600 mg.

For the prevention of infectious complications after surgical interventions on the organs of the genitourinary system apply once 50 mg 30 minutes before the operation.

Side effects:

Disorders from the gastrointestinal tract: nausea, vomiting, decreased appetite, anorexia, diarrhea, pancreatitis.

Disturbances from the nervous system: dizziness, headache, drowsiness, weakness, peripheral neuropathy, the development of polyneuritis. Disturbances on the part of the organ of vision: visual impairment.

Disorders from the liver and bile ducts: a violation of the liver, cholestatic jaundice, hepatitis.

Disorders from the musculoskeletal and connective tissue: myalgia, arthralgia.

Violations from the blood and lymphatic system: agranulocytosis, thrombocytopenia, aplastic anemia, eosinophilia.

Violations of the respiratory system, organs, thoracic and mediastinal disorders: shortness of breath, chest pain, cough with or without sputum, interstitial pneumonitis, pulmonary fibrosis.

Vascular disorders: intracranial hypertension.

Disorders of the skin and subcutaneous tissues: skin rash (including papular..) Enantemy, angioedema, pruritus, urticaria, exfoliative dermatitis, erythema multiforme.

Other: fever, reversible alopecia.

Overdose:

Symptoms: neurotoxic reactions, polyneuritis, impaired function liver, acute toxic hepatitis.

Treatment: removal of the drug, drinking large amounts of fluid, symptomatic therapy, antihistamine drugs, vitamins of group B. No specific antidote.

Interaction:

Ristomycin, chloramphenicol, sulfonamides - the risk of hematotoxic action.

It should avoid the simultaneous use of other derivatives of nitrofuran, as well as drugs that "acidify" urine (including ascorbic acid, calcium chloride). Medicinal preparations, "alkalizing" the urine, accelerate the excretion of furazidine with urine. Ethanol can increase the severity of side effects.

Probenecid and sulfinpyrazone reduce the excretion of furazidine with urine. This can lead to a cumulation of furazidine and an increase in its toxicity.

With the simultaneous use of magnesium-containing antacids decreases absorption of furazidine.

Special instructions:

To prevent the development of side effects, drink plenty of liquids. To prevent the development of neuritis, vitamins of group B should be prescribed. Stains urine in brown color.

With long-term use, monitoring of peripheral blood picture, kidney and liver function, lung function is necessary.

There may be false-positive results in the determination of glucose in urine using enzymatic methods.

When using the drug, it is possible to develop diarrhea caused by Clostridium difficile (pseudomembranous colitis).In mild cases, it is sufficient to cancel the drug, in severe cases it is necessary to prescribe the appropriate treatment. Do not use drugs that inhibit the intestinal peristalsis.

Effect on the ability to drive transp. cf. and fur:

During the period of treatment, one should refrain from driving vehicles and engaging in other activities that require a high concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Tablets 50 mg.

Packaging:

30 tablets per blister of PVC / Al.

Each blister along with the instruction but application in a cardboard box.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LP-003244

Date of registration:08.10.2015

Representation: & nbspAdamed RASHA LLCAdamed RASHA LLCRussia

Information update date: & nbsp10.09.2015

Illustrated instructions

Instructions

Urofuragin (Urofuragin)