Included in the formulation
АТХ:D.08.A.F Nitrofuran derivatives
J.01.X.E Nitrofuran derivatives
Pharmacodynamics:It suppresses the respiratory chain and the cycle of tricarboxylic acids, inhibits the biochemical processes of respiration of microorganisms, inhibits the synthesis of nucleic acids, as a result of which their shells or cytoplasmic membranes are destroyed.
Has a bacteriostatic effect against gram-positive cocci: Streptococcus spp., Staphylococcus spp., Gram-negative rods: Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp., Enterobacter spp. and the simplest: Giardia.
Pharmacokinetics:After oral administration, it is absorbed in the thin section of the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 3 hours and remains for 8 hours.
Metabolism in the liver.
The half-life is 4 hours.Elimination by the kidneys.
Indications:Used internally for the treatment of infectious and inflammatory diseases of the urinary tract, infectious complications after surgical intervention on the organs of the genitourinary system.
It is used topically for infectious and inflammatory diseases of the urogenital system, burns, purulent and infected wounds, fistulas, keratitis, conjunctivitis, for bronchial sanitation during medical bronchoscopy, rinsing cavities in peritonitis, empyema of the pleura, purulent arthritis.
XII.L00-L08.L02 Abscess of skin, boil and carbuncle
XII.L00-L08.L03 Phlegmon
XII.L00-L08.L08.0 Pyoderma
XIV.N10-N16.N11 Chronic tubulointerstitial nephritis
XIV.N10-N16.N10 Acute tubulointerstitial nephritis
XIV.N30-N39.N30 Cystitis
XIV.N30-N39.N34 Urethritis and urethral syndrome
XIV.N70-N77.N73.0 Acute parametritis and pelvic cellulite
XXI.Z20-Z29.Z29.2 Another type of preventive chemotherapy
Contraindications:Chronic renal failure, individual intolerance, children under 4 years.
Carefully:Diseases of the nervous system and liver, deficiency of glucose-6-phosphate dehydrogenase, hypersensitivity.
Pregnancy and lactation:Recommendations for FDA - category is not defined. It is used with caution during pregnancy and lactation in cases where the intended benefit exceeds the risk to the fetus and newborn.
Dosing and Administration:Use in children
Contraindicated up to 4 years of age.
Inside for 25-50 mg 3 times a day.
With the goal of preventing postoperative complications: 25 mg once for 30 minutes before surgery.
Adults
Inside after eating 100-200 mg 2-3 times a day.
Outer: solution (1: 13000 in physiological solution) for wetting the dressing and washing the wounds.
Locally: in the form of rinses of the mouth and throat 2-3 times a day.
In order to prevent infection, including urological operations, cystoscopy, catheterization - 50 mg once for 30 minutes before the procedure.
The highest daily dose: 600 mg.
The highest single dose: 200 mg.
Side effects:Central and peripheral nervous system: dizziness, headache, with prolonged use - peripheral neuritis.
Digestive system: anorexia, nausea, vomiting.
Dermatological reactions: itching, papular rashes.
Allergic reactions.
Overdose:Neurotoxic reactions: ataxia, tremor.
Treatment is symptomatic.
Interaction:Tetracycline and aminoglycosides increase antimicrobial activity
With simultaneous use with sulfonamides, ristomycin, chloramphenicol, the risk of oppression of hematopoiesis increases.
Urine-lowering agents reduce the effect, since it speeds up the release of the drug with urine. Means, acidifying urine - increase.
Special instructions:It is necessary to combine the drug with Group B vitamins with long-term use to prevent the development of polyneuritis.