Furagin-Aktifur - instructions for use, dose, side effects, contraindications

Excipients: Magnesium carbonate basic water 36.0 mg / 72.0 mg, starch corn re-gelatinized 22.6 mg / 45.2 mg, silicon dioxide colloid (aerosil) 3.15 mg / 6.3 mg, croscarmellose sodium 6.0 mg / 12.0 mg, talc 1.0 mg / 2.0 mg; hard gelatine capsules: body and cap capsule - titanium dioxide 1.3333%, dye quinoline yellow 0.9197%, dye sunset yellow 0.0044%, gelatin - up to 100%.

Description:

Hard gelatin capsules No. 3 (dosage 25 mg) or No. 1 (dosage 50 mg) with a body and a lid of yellow color. The contents of the capsules are orange powder.

Pharmacotherapeutic group:Antimicrobial agent, nitrofuran

ATX: & nbsp

D.08.A.F Nitrofuran derivatives

J.01.X.E Nitrofuran derivatives

Pharmacodynamics:

A broad-spectrum antimicrobial agent belonging to the group of nitrofurans. Resistance to furazidine develops slowly and does not reach a high degree. Active against gram-positive and gram-negative microbes, pathogenic strains Staphylococcus spp. and other microorganisms resistant to antibiotics. Effective against gram-positive cocci (streptococci, staphylococcus), gram-negative rods (eshirichia coli, salmonella, shigella, protea, klebsiella, enterobacteria), protozoa (lamblia). Furazidine more active in relation to staphylococci, Escherichia coli, Aerobacter aerogenes, Bacterium citrovorum, Proteus mirabilis, Proteus morganii, compared c other nitruburans. Furazidine shows a higher activity towards Enterococcus faecalis, Staphylococcus spp. compared with other groups of antimicrobial drugs.

Against most bacteria, the bacteriostatic concentration ranges from 1: 100,000 to 1: 200,000. The bactericidal concentration is approximately twice as large. Under the influence of nitrofurans in microorganisms, the respiratory chain and the cycle of tricarboxylic acids (Krebs cycle) are suppressed, as well as the inhibition of other biochemical processes of microorganisms,as a result of which their shell or cytoplasmic membrane is destroyed. As a result of the action of nitrofurans, microorganisms produce less toxins, so that the improvement of the general state is possible even before the expressed suppression of microflora growth. Nitrofurans, unlike many other antimicrobials, not only do not inhibit the immune system of the body, but on the contrary, activate it (increase the complement titre and the ability of leukocytes to phagocytose microorganisms). In therapeutic doses, nitrofurans stimulate leukopoiesis.

Pharmacokinetics:

Suction

After taking the drug inside furazidine absorbed in the small intestine by passive diffusion. Absorption of nitrofurans from the distal segment of the small intestine exceeds absorption from the proximal and medial segments by 2 and 4 times, respectively (should be taken into account in the simultaneous treatment of urogenital infections and diseases of the gastrointestinal tract, including chronic enteritis). Nitrofurans are poorly absorbed in the large intestine.

Being a mixture of furozidin sodium and magnesium carbonate basic, Furagin-Aktifur with oral administration has a higher bioavailability than simple furazidine (after taking the capsule Furagin-Aktifur in the acidic environment of the stomach, there is no conversion of furazidine sodium into poorly soluble furazidine).

Distribution

In organism furazidine distributed evenly. Clinically important is the high content of the active substance in the lymph (delaying the spread of infection through the lymphatic ways). In bile, its concentration is several times higher than in serum, and in cerebrospinal fluid it is several times lower than in serum. In saliva, the content of furazidine is 30% of its serum concentration. The concentration of furazidine in the blood and tissues is relatively small, which is due to its rapid release, while the concentration in the urine is much higher than in the blood. The maximum concentration in the blood plasma is kept from 3 to 7 or 8 hours, in the urine furazidine is found 3-4 hours after application.

Metabolism

Furazidine slightly biotransformed (less than 10% of the administered dose), with a decrease in excretory function of the kidneys, the intensity of metabolism increases.

Excretion

Unlike nitrofurantoin, urine does not change after taking furazidine. 4 hours after taking the drug, the concentration of furazidine in urine is significantly higher than the concentration that is formed after taking the same dose of nitrofurantoin.It is excreted through the kidneys by glomerular filtration and tubular secretion (85%), partially subjected to reverse reabsorption in tubules. At low the concentration of furazidine in the urine is dominated by the process of filtration and secretion, at high concentrations the secretion decreases and reabsorption increases. Furazidine, being a weak acid in acid urine does not dissociate, undergoes intensive reabsorption, which can increase the development of systemic side effects. With alkalization of urine, excretion of furazidine is enhanced.

Indications:

Infections caused by susceptible to furazidine by microorganisms: urogenital infections (acute cystitis, urethritis, pyelonephritis), gynecological infections.

Prevention of infections in urological operations, cystoscopy, catheterization.

Contraindications:

Hypersensitivity to nitrofuran group preparations.

Pregnancy, the period of breastfeeding.

Severe chronic renal failure.

Impaired renal function.

Children under 3 years.

Carefully:

Deficiency of glucose-6-phosphate dehydrogenase.

Pregnancy and lactation:

The use of furazidine during pregnancy and during breastfeeding is contraindicated.If furazidine is needed during breastfeeding, breast-feeding should be discontinued.

Dosing and Administration:

Inside, after eating, squeezed a lot of liquid.

With urogenital infections (acute cystitis, urethritis, pyelonephritis), gynecological infections:

Adults appoint 50-100 mg 3 times a day.

Children prescribe 25-50 mg 3 times a day (but not more than 5 mg / kg of body weight per day).

The course of treatment is from 7-10 days. If it is necessary to repeat the course of treatment, you should take a break for 10-15 days.

For the prevention of infection in urological operations, cystoscopy, catheterization:

Adults appoint 50 mg once for 30 minutes before the procedure.

Children prescribe 25 mg once for 30 minutes before the procedure.

If you forget to take the next dose, take the next dose at the usual time. Do not take a double dose to replace the missed dose.

Side effects:

The incidence of unwanted reactions is presented according to WHO classification: very often (> 1/10 cases), often (> 1/100 and <1/10 cases) infrequently (> 1/1000 and <1/100 cases), rarely (> 1/10000 and <1/1000 cases) and very rarely (<1/10000 cases).

From the skin and subcutaneous tissues: rarely - allergic reactions (skin rash, papular rashes).

From the nervous system: often - headache; infrequently - dizziness; rarely - polyneuritis.

From the gastrointestinal tract: infrequently - nausea; rarely vomiting, loss of appetite.

From the liver and biliary tract: very rarely - violations of the liver. If any of the unwanted reactions listed in the manual is aggravated, or if you notice other undesirable reactions not listed in the instructions, inform your doctor.

Overdose:

Symptoms: symptoms of a neurotoxic nature, ataxia, tremor.

Treatment: In case of an overdose, drink plenty of fluids. For relief of acute symptoms, antihistamines are used. For the prevention of neuritis, the administration of vitamins (thiamine bromide) is possible.

Interaction:

Do not use furazidine simultaneously with ristomycin, chloramphenicol, sulfonamides, as the risk of oppression of hematopoiesis increases.

During the treatment period, it is advisable to refrain from drinking alcoholic beverages, as may side effects of furazidine.

It is not recommended to apply simultaneously with drugs that can "acidify" urine (including ascorbic acid, calcium chloride).

Special instructions:

To reduce the likelihood of side effects, the drug is washed down with a large amount of liquid.

If side effects occur, the drug should be discontinued (toxic effects are more frequent in patients with reduced renal excretory function).

If any of the side effects indicated in the manual are aggravated, or any other side effects not indicated in the instructions are noted, you should inform the doctor immediately.

Effect on the ability to drive transp. cf. and fur:

Given the possible side effects of furazidine from the nervous system, care must be taken when driving vehicles, and also in other occupations potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Capsules 25 mg and 50 mg.

Packaging:

For 10, 15, 20, 30 capsules in a contour cell box made of a polyvinylchloride film and aluminum foil printed lacquered.

For 1, 2, 3, 4, 5 contour squares with instructions for use in a pack of cardboard.

Storage conditions:

In dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LP-002457

Date of registration:07.05.2014

The owner of the registration certificate:OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Manufacturer: & nbsp

OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Representation: & nbspOBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSCOBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSCRussia

Information update date: & nbsp11.11.2015

Illustrated instructions

Instructions

Furagin Aktifur (Furagin-Aktifur)