Indomethacin - instructions for use, dose, side effects, contraindications

Has anti-inflammatory, analgesic, anti-edematous effect associated with nonselective inhibition of cyclooxygenase-1 (COX1) and cyclooxygenase-2 (COX2) regulating the synthesis of anti-inflammatory prostaglandins. Eliminates pain, reduces swelling, erythema, morning stiffness and swelling of the joints, contributes to an increase in the volume of movements.

Pharmacokinetics:

Absorbed through the skin, with repeated use accumulates in the underlying tissues, muscles, joints and synovial fluid. With external application, a clinically insignificant amount of indomethacin can enter the systemic bloodstream, from which it is excreted by the kidneys in the form of metabolites and in an insignificant amount unchanged, and also partially through the gastrointestinal tract.

Indications:

- Inflammatory and degenerative diseases of the musculoskeletal system: articular syndrome with exacerbation of gout, rheumatoid arthritis, juvenile chronic arthritis, ankylosing spondylitis (Bechterew's disease), osteochondrosis with radicular syndrome, osteoarthrosis of various locations, sciatica, inflammatory lesions of ligaments and tendons, sciatica, lumbago ;

- muscular pain of rheumatic and non-rheumatic origin, periarticular diseases: tendonitis, bursitis, tendo bursitis, tendovaginitis;

- posttraumatic inflammation of soft tissues and structures of the musculoskeletal system: injuries and ruptures of ligaments, bruises.

Contraindications:

- Hypersensitivity to indomethacin, other NSAIDs, or other components of the drug (including dimexide);

- complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including in the anamnesis);

- violation of the integrity of the skin at the site of the intended application of the drug;

- pregnancy of the III trimester and the period of breastfeeding;

- Children under 6 years.

Carefully:

Allergic diseases and reactions, violations of the liver and kidneys (in case of application to large areas of the skin surface), erosive and ulcerative lesions of the gastrointestinal tract, disorders of blood clotting (including hemophilia, prolonged bleeding time, a tendency to bleed), concomitant use of NSAIDs, hepatic porphyria (exacerbation), advanced age, children age 6 to 12 years, pregnancy I-II trimesters.

Pregnancy and lactation:

Contraindicated in the III trimester of pregnancy and during breastfeeding.

Dosing and Administration:

Outwardly.

Adults and children from the age of 12 ointment rubbing lightly, a thin layer in the skin over the painful zone of 4-5 cm 3-4 times a day.

Children from 6 to 12 years old apply 2-2.5 cm 2-3 times a day.

The interval between application of the ointment should be at least 6 hours. The course of treatment is 7-10 days.

The total amount of ointment for adults per day should not exceed 15 cm, squeezed out of the tuba, for children - 7.5 cm.

It is not recommended to use occlusive dressings.

Side effects:

Sometimes itching and hyperemia of the skin, burning, rashes, peeling, dry skin can occur.

Rarely develops local edema and vesicular rash, and in some cases - angioedema and dyspnea.

When applied to a large area of the skin surface, systemic reactions may occur, mainly gastrointestinal disturbances (lack of appetite, nausea, vomiting, diarrhea, abdominal pain, bleeding and ulcerations).

In isolated cases - exacerbation of psoriasis.

Overdose:

Extremely low systemic absorption of active components of the drug with external application makes an overdose almost impossible.

The phenomenon of overdose (mainly from the gastrointestinal tract) is not excluded only with prolonged use on a large area of the skin surface.

If the product gets inside, burning in the mucous membrane of the mouth, salivation, nausea, vomiting, in this case, you should wash the mouth and stomach, taking activated charcoal, if necessary symptomatic treatment.

Interaction:

Ointment can enhance the effect of drugs that cause photosensitivity.

Clinically significant interaction with other drugs with this method of use is not described.

Special instructions:

The drug should be applied only to intact and uninfected areas of the skin.

Avoid contact with the eyes, mouth, mucous membranes or open wounds, as in this case there is local irritation - lacrimation, redness, burning, pain (treatment - abundant rinsing of the affected area with running water or 0.9% solution of sodium chloride up to the reduction or disappearance of complaints).

When rashes appear, treatment should be stopped immediately.

With prolonged treatment (more than 10 days), it is recommended to conduct a laboratory control of the content of leukocytes and platelets.

Effect on the ability to drive transp. cf. and fur:

There is no evidence of impairment of the ability to drive a car and engage in other potentially hazardous activities requiring rapidity of psychomotor reactions and increased concentration of attention.

Form release / dosage:Ointment for external use, 10%.

Packaging:

40 grams per tube aluminum.

By 10, 15, 20, 25, 30 or 40 g in cans of dark glass such as BTS made of glass fiber with pull-on lids. The label is self-adhesive on the can.

Each tube or jar, together with the instruction for use, is placed in a cardboard package (bundle).

Storage conditions:

AT protected from light at a temperature of no higher than 20 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-002242

Date of registration:23.09.2013

Expiration Date:23.09.2018

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Representation: & nbspOZONE LLC OZONE LLC Russia

Information update date: & nbsp31.10.2017

Illustrated instructions

Instructions

Indomethacin (Indometacinum)