From the digestive system: NSAIDs-gastropathy, nausea, heartburn, decreased appetite, abdominal pain, hemorrhages and ulcers, vomiting (including bloody), diarrhea, constipation, melena, ulcerative stomatitis, increased activity of "liver transaminases" (ALAT, ACAT) , transient increase in bilirubin; rarely - toxic hepatitis with or without jaundice; very rarely - fulminant hepatitis. With prolonged use in large doses - ulceration of the mucous membrane of the gastrointestinal tract.
From the nervous system: headache, dizziness, insomnia, agitation, irritability, excessive fatigue, drowsiness, depression, peripheral neuropathy.
From the sense organs: diplopia, blurred vision, hearing loss, tinnitus, impaired taste, corneal opacity, conjunctivitis.
From the cardiovascular system: tachyarrhythmia, edematous syndrome, increased arterial pressure, the development (aggravation) of chronic heart failure.
From the urinary system: renal dysfunction, nephrotic syndrome, proteinuria, hematuria, interstitial nephritis, papillary necrosis.
On the part of the organs of hematopoiesis and the system of hemostasis: bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), leukopenia, thrombocytopenia, agranulocytosis, anemia (including hemolytic and aplastic), eosinophilia, thrombocytopenic purpura.
Allergic reactions: usually itchy skin, skin rash; rarely - urticaria, bronchospasm, asthmatic attacks, angioedema; very rarely - bullous eruptions, skin redness, eczema, exfoliative dermatitis, allergic-type purpura, Stevens-Johnson syndrome; in isolated cases - photosensitivity, toxic epidermal necrolysis (Lyell's syndrome), erythema nodosum, anaphylactic shock.
Laboratory indicators: agranulocytosis, leukopenia, thrombocytopenia, hyperglycemia, glucosuria, hyperkalemia.
Local reactions: irritation, heaviness in the anorectal area, exacerbation of hemorrhoids.
Other: aseptic meningitis (more often in patients with autoimmune diseases), increased sweating, aplastic anemia, autoimmune hemolytic anemia.