Active substanceCalcium chlorideCalcium chloride
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    BIOCHEMIST, OJSC     Russia
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    DALHIMFARM, OJSC     Russia
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    SYNTHESIS, OJSC     Russia
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  • Dosage form: & nbspsolution for intravenous administration
    Composition:

    1 ml of the preparation contains:

    active substance: calcium chloride - 100 mg;

    auxiliary substance: water for injection - up to 1 ml.

    Description:Transparent colorless liquid.
    Pharmacotherapeutic group:Calcium-phosphorus exchange regulator
    ATX: & nbsp

    B.05.X.A   Electrolyte solutions

    B.05.X.A.07   Calcium chloride

    Pharmacodynamics:The calcium supplement Ca2 + replenishes the deficiency of calcium ions (Ca2 +), necessary for the process of nerve impulse transmission, reduction of skeletal and smooth muscles, myocardial activity, bone formation, and blood coagulation.Reduces the permeability of cells and the vascular wall, prevents the development of inflammatory reactions, increases the body's resistance to infections and can significantly enhance phagocytosis (phagocytosis, which decreases after taking sodium chloride (NaCl), increases after administration of Ca2 +). With intravenous injection stimulates the sympathetic division of the autonomic nervous system, enhances the secretion of epinephrine by the adrenal glands, and has a moderate diuretic effect.
    Pharmacokinetics:In plasma about 45% is in complex with proteins. About 20% is excreted by the kidneys, the rest (80%) is removed from the intestinal contents. 95% Ca2 + released by glomerular filtration, undergoes reabsorption in the ascending segment of the Henle loop, as well as in the proximal and distal renal tubules.
    Indications:Increased demand for Ca2 + (pregnancy, lactation period, period of increased body growth); bleeding of various etiology and localization (pulmonary, gastrointestinal, nasal, uterine, etc.); allergic diseases (serum sickness, urticaria, febrile syndrome, itching, angioedema); bites and stings of insects, lead colic; hypoparathyroidism,hypocalcemia, increased vascular permeability (hemorrhagic vasculitis, radiation sickness), poisoning with magnesium salts (Mg2+), oxalic and fluoric acids.
    Contraindications:

    Hypersensitivity to the components of the drug, a tendency to thrombosis, severe atherosclerosis, hypercalcemia.

    Pregnancy and lactation:With increased demand for Ca2+ during pregnancy and lactation, the use of the drug as directed by a doctor is recommended.
    Dosing and Administration:

    Calcium chloride is administered intravenously in a stream or drip with a speed of no more than 0.75-1.5 ml / min. The ampoule with the solution before the introduction is heated to the temperature of the body. After completion of the administration, the patient should a short time to remain in the "lying" position.

    For allergic diseases (urticaria, angioneurotic edema, allergic dermatoses, serum sickness), bites or stings of insects, lead colic, drug overdose Mg2+ - 7,5-15 ml.

    In acute hypocalcemia - 7.5-15 ml for 1-3 days, with The need to repeat is repeated every 1-3 days.

    With hypocalcemic tetany - 5-17.5 ml. The introduction is repeated every 8 h before reaching a therapeutic effect.

    With giperkaliemii (under the control of ECG) - 2.45-15 ml, if necessary, the repeated dose is administered after 1-2 minutes.

    Children - 0.3 ml / kg, the maximum daily dose - 1.5 ml.

    For intravenous drip injection, the solution is previously diluted with 5% dextrose solution or 0.9% sodium chloride solution

    Side effects:

    With rapid administration, there is a feeling of heat, hyperemia of the skin of the face, smack of chalk in the mouth, peripheral vasodilation, lowering of blood pressure, arrhythmia (including bradycardia), fainting. Rarely (with impaired renal function) - hypercalcemia.

    Local reactions: irritation along the veins; skin hyperemia, pain, rash, calcification may indicate extravasation, which can lead to necrosis of surrounding tissues.

    Overdose:

    Symptoms: hypercalcemia (thirst, nausea, vomiting, constipation, polyuria, abdominal pain, muscle weakness, mental disorders, in severe cases - arrhythmia, coma), especially in patients with CRF.

    Treatment: with a slight overdose (concentration of Ca2 + - 2,6-2,9 mmol / l), the administration is stopped and other calcium-containing drugs are canceled.In severe overdose (concentration of Ca2 + more than 2.9 mmol / l), 0.9% solution NaCl, non-diasidic diuretics; The concentration of K + and Mg2+ in the serum, and if necessary - drugs K + Mg2+; control cardiovascular system, the introduction of beta-adrenoblockers for the prevention of arrhythmias, hemodialysis.

    Interaction:

    When used simultaneously with cardiac glycosides, it increases the risk of arrhythmias (concomitant use is contraindicated).

    Reduces the effectiveness of calcium channel blockers.

    Strengthens the action of antihistamines.

    Simultaneous reception with other Ca2 + or Mg2 + -containing drugs increases the risk of hyperkalemia or hypermagnia, respectively, especially in patients with chronic renal failure.

    Reduces the effectiveness of nondepolarizing muscle relaxants. May increase the duration of action of tubocurarine chloride.

    Pharmaceutically incompatible with tetracyclines, magnesium sulfate, drugs containing phosphates, carbonates or tartrates.

    Compatible with 5% dextrose and 0.9 % solution of sodium chloride.

    Special instructions:

    Treatment is carried out under the control of Ca2 + concentration in the blood.

    You can not inject subcutaneously and intramuscularly - necrosis of tissues is possible (high concentrations of calcium chloride (CaCl2), starting at 5%, cause severe irritation of surrounding tissues).

    If pain or hyperemia occurs at the injection site, discontinue administration and exclude extravasation.

    With the intravenous administration of calcium chloride, a sensation of heat in the oral cavity appears, then throughout the body (previously used to determine the rate of blood flow - the time between the moment of its introduction into the vein and the appearance of a sensation of heat).

    Effect on the ability to drive transp. cf. and fur:No data.
    Form release / dosage:

    Solution for intravenous administration is 100 mg / ml.

    Packaging:

    10 ml into neutral glass ampoules. For 10 ampoules together with instructions for use and scarifier ampoule in a box of cardboard.

    Storage conditions:

    Store at temperatures between 2 and 30 ° C. Keep out of the reach of children place.

    Shelf life:5 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LS-000366
    Date of registration:09.04.2010 / 15.06.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:MOSHIMFARM PREPARATES them.N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp20.11.2017
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