Calcium chloride - instructions for use, dose, side effects, contraindications

Pharmacodynamics:The preparation of calcium replenishes the calcium deficiency necessary for the process of transmission of nerve impulses, the reduction of skeletal and smooth muscles, myocardial activity, the formation of bone tissue, and the coagulation of blood. Reduces permeability of cells and vascular wall.

Pharmacokinetics:In plasma about 45% is in complex with proteins. About 20% is excreted by the kidneys, The remaining amount (80%) is removed from the intestinal contents. 95% of calcium emitted by glomerular filtration undergoes reabsorption in the ascending segment of the Henle loop, as well as in the proximal and distal renal tubules.

Indications:

Allergic diseases (hives, angioedema, allergic dermatoses, serum sickness), bites and stings of insects, hypocalcemia (including hypocalcemia tetany, with hypoparathyroidism), lead colic, hyperkalemia, overdose with magnesium preparations (as part of complex therapy).

Contraindications:

Hypersensitivity, hypercalcaemia, hypercalciuria, severe chronic renal failure (CRF), ventricular fibrillation, urolithiasis, sarcoidosis, simultaneous reception of cardiac glycosides; pregnancy, lactation.

Carefully:

CRF of light, and moderate severity, dehydration, disturbance of electrolyte balance (risk of hypercalcemia), heart disease (risk of arrhythmia), kidney disease, pulmonary heart disease, respiratory acidosis, respiratory failure (risk toxic reactions due to the oxidation of calcium chloride).

Dosing and Administration:

Intravenously spray or drip at a speed of no more than 0.75-1.5 ml / min. After completion of the administration, the patient should remain for a short time in the "lying" position.

For allergic diseases (urticaria, angioneurotic edema, allergic dermatoses, serum sickness), bites and insect stings, lead colic, overdose with magnesium preparations - 7,5-15 ml.

In acute hypocalcemia - 7.5-15 ml for 1-3 days, if necessary, administration - repeat every 1-3 day.

With hypocalcemic tetany 5-17.5 ml. The administration is repeated every 8 hours until a therapeutic effect is achieved.

With giperkaliemii (under the control of ECG) - 2.45-15 ml, if necessary, the repeated dose is administered after 1-2 minutes.

Children - 0.3 ml / kg, the maximum daily dose of 15 ml.

For intravenous drip injection, the solution is previously diluted with 5% dextrose solution or 0.9% sodium chloride solution.

Side effects:

With a quick introduction - a feeling of heat, hyperemia of the face, a taste of chalk in the mouth, peripheral vasodilation, lowering blood pressure, arrhythmia (incl. bradycardia), faint. Rarely (with impaired renal function) - hypercalcemia.

Local reactions: irritation along the veins; skin hyperemia, pain, rash, calcification may indicate extravasation, which can lead to necrosis of surrounding tissues.

Overdose:

Symptoms: hypercalcemia (thirst, nausea, vomiting, constipation, polyuria, abdominal pain, muscle weakness, mental disorders, in severe cases - arrhythmia, coma), especially in patients with CRF.

Treatment: with a slight overdose (concentration of calcium - 2,6-2,9 mmol / l) administration stops and abolishes other calcium-containing drugs. In severe overdose (calcium concentration more than 2.9 mmol / l), 0.9% sodium chloride solution, non-diazide diuretics; control the concentration of potassium and magnesium in the serum, and if necessary - administer potassium and magnesium preparations; control functions of the cardiovascular system, the introduction of beta-adrenoblockers for the prevention of arrhythmias, hemodialysis.

Interaction:

When used simultaneously with cardiac glycosides, it increases the risk of arrhythmias (concomitant use is contraindicated).

Reduces the effectiveness of slow calcium channel blockers.

Simultaneous reception with others calcium- or magnesium-containing drugs increases the risk of hyperkalemia or hypermagnesia respectively, especially in patients with CRF.

Reduces the effectiveness of nondepolarizing muscle relaxants. May increase the duration of action of tubocurarine chloride.

Pharmaceutically incompatible with tetracyclines, magnesium sulfate, drugs containing phosphates, carbonates or tartrates.

Compatible with 5% dextrose and 0.9 % solution of sodium chloride.

Special instructions:

Treatment is carried out under the control of the concentration of calcium in the blood.

Do not administer subcutaneously or intramuscularly - tissue necrosis is possible (high concentrations of calcium chloride, starting at 5%, cause severe irritation surrounding tissues).

If pain or hyperemia occurs at the injection site, discontinue administration and exclude extravasation.

With intravenous administration of calcium chloride, a feeling of heat first appears in the oral cavity, and then throughout the body.

Form release / dosage:Solution for intravenous administration is 100 mg / ml.

Packaging:

In ampoules of 5 ml or 10 ml.

For 10 ampoules with instructions for use, with an ampoule or ampoule ampoule knife in a pack or box of cardboard. When packaging ampoules that have a break ring or an opening point, the ampoule knife or the ampoule scapegrator is not put in.

5 ampoules in a cassette outline package. 2 cassette contour packs with instructions for use in a pack of cardboard.

Storage conditions:

At temperatures from 18 to 25 FROM.

Keep out of the reach of children.

Shelf life:5 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-002097

Date of registration:07.10.2011 / 04.09.2013

Expiration Date:Unlimited

The owner of the registration certificate:MICROGEN FGUP Scientific and Production Association MICROGEN FGUP Scientific and Production Association Russia

Manufacturer: & nbsp

MICROGEN FGUP NGO Russia

Information update date: & nbsp23.11.2017

Illustrated instructions

Instructions

Calcium chloride (Calcium chloride)