Calcium chloride - instructions for use, dose, side effects, contraindications

The preparation of calcium replenishes the calcium deficiency necessary for the process of transmission of nerve impulses, the reduction of skeletal and smooth muscles, myocardial activity, the formation of bone tissue, and the coagulation of blood. Reduces the permeability of vascular wall cells.

Pharmacokinetics:

About 45% is in complex with plasma proteins. It is excreted by the kidneys (20%) and the intestine (80%). 95% of calcium released by glomerular filtration, undergoes reabsorption in the ascending segment of the Henle loop, as well as in the proximal and distal renal tubules.

Indications:

Allergic diseases (urticaria, angioedema, allergodermatosis, serum sickness), insect bites and stings, hypocalcemia (including hypocalcemia tetany, with hypoparathyroidism), lead colic, hyperkalemia, overdose with magnesium preparations (as part of complex therapy).

Contraindications:

Hypersensitivity to the drug, hypercalcemia_,hypercalciuria, severe chronic renal failure, ventricular fibrillation, urolithiasis, sarcoidosis, simultaneous reception of cardiac glycosides; pregnancy, lactation.

Carefully:Chronic renal failure of mild to moderate severity, dehydration, electrolyte balance disorder (risk of hypercalcemia), heart disease (risk of arrhythmia), kidney disease, pulmonary heart disease, respiratory acidosis, respiratory failure (risk of toxic reactions due to calcium chloride oxidation).

Dosing and Administration:

Intravenously spray (slow) or drip at a speed of no more than 0.75 - 1.5 ml / min.

After completion of the administration, the patient should remain for a short time in the "lying" position.

For allergic diseases (urticaria, angioneurotic edema, allergic dermatoses, serum sickness), bites and insect stings, lead colic, overdose with magnesium preparations - 7,5-15 ml.

In acute hypocalcemia - 7,5-15 ml for 1-3 days, if necessary, the administration is repeated every 1-3 days.

With hypocalcemia tetany - 5-17,5 ml. The administration is repeated every 8 hours until a therapeutic effect is achieved.

With giperkaliemii (under the control of ECG) - 2.45-15 ml, if necessary, the repeated dose is administered after 1-2 minutes.

Children - 0.3 ml / kg, the maximum daily dose of 15 ml.

For intravenous drip, the solution is previously diluted 5%. solution of dextrose or 0.9% solution of sodium chloride.

Side effects:

With a quick introduction - a feeling of heat, flushing of the face, smack of chalk in, mouth, peripheral vasodilation, lowering of arterial pressure, arrhythmia (including bradycardia), fainting. Rarely (with impaired renal function) - hypercalcemia.Local reactions: irritation along the veins; skin hyperemia, pain, rash, calcification may indicate extravasation, which can lead to necrosis of surrounding tissues.

Overdose:

Symptoms: hypercalcemia (thirst, nausea, vomiting, constipation, polyuria, abdominal pain, muscle weakness, mental disorders, in severe cases - arrhythmia, coma), especially in patients with chronic renal failure.

Treatment: with a slight overdose (calcium concentration - 2,6 - 2,9 mmol / l), the administration is stopped and other calcium-containing medicines. In severe overdose (calcium concentration more than 2.9 mmol / l), 0.9% sodium chloride solution, non-diazide diuretics; control the concentration of potassium and magnesium in the serum, and if necessary - administer potassium and magnesium preparations; control of cardiovascular function, the introduction of beta-adrenoblockers for the prevention of arrhythmias, hemodialysis.

Interaction:

When used simultaneously with cardiac glycosides, it increases the risk of arrhythmias (concomitant use is contraindicated).

Reduces the effectiveness of blockers of "slow" calcium channels.

Simultaneous reception with other calcium - and magnesium-containing drugs increases the risk of hyperkalemia or hypermagnia, respectively, especially in patients with chronic renal failure.

Reduces the effectiveness of nondepolarizing muscle relaxants.

May increase the duration of action of tubocurarine chloride.

Pharmaceutically incompatible with tetracyclines, magnesium sulfate, drugs containing phosphates, carbonates or tartrates.

Compatible with 5% solution of dextrose and 0.9% solution of sodium chloride.

Special instructions:

Treatment is carried out under the control of the concentration of calcium in the blood.

Do not administer subcutaneously or intramuscularly - tissue necrosis is possible (high concentrations of calcium chloride, starting at 5%, cause severe irritation of surrounding tissues).

If pain or hyperemia occurs at the injection site, discontinue administration and exclude extravasation.

With the intravenous administration of calcium chloride, a sensation of heat appears first in the oral cavity, and then throughout the body.

Form release / dosage:

Solution for intravenous administration is 100 mg / ml.

Packaging:

5 ml or 10 ml into neutral glass ampoules.

For 10 ampoules, together with the instruction for use and the ampoule opening opener or ampoule scarifier, is placed in a cardboard box.

When using ampoules with break points, incisions, rings, a knife for opening ampoules or an ampoule scarifier is allowed not to be put.

Storage conditions:

Store at a temperature of 5 to 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-000510

Date of registration:06.05.2010

The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia

Manufacturer: & nbsp

DALHIMFARM, OJSC Russia

Information update date: & nbsp14.09.2015

Illustrated instructions

Instructions

Calcium chloride (Calcium chloride)