Ketoconazole - instructions for use, dose, side effects, contraindications

Excipients: butyl hydroxy anisole 0.5 mg, semisynthetic glycerides (Supposir AM) - a sufficient amount to obtain a suppository with a mass of 2000 mg.

Description:

Suppositories of the shape of a cylinder with a pointed end, white or white with a yellowish hue of color. On the cut, an air rod or a funnel-shaped depression is allowed.

Pharmacotherapeutic group:Antifungal agent

ATX: & nbsp

J.02.A.B.02 Ketoconazole

D.01.A.C.08 Ketoconazole

Pharmacodynamics:

Ketoconazole (an imidazole-dioxole derivative) is a synthetic antifungal agent for a wide range of effects for topical application.

It has fungicidal and fungistatic action against dermatophytes: Trichophyton spp., Epidermophyton floccosum, Microsporum spp.; yeast and yeast-like fungi: Candida spp., Pityrosporum spp., Torulopsis, Cryptococcus spp., of dimorphic fungi and eumitsetov. The drug is active against staphylococci and streptococci.The mechanism of action is to inhibit the biosynthesis of ergosterol and change the lipid composition of the fungal membrane.

Pharmacokinetics:

Systemic absorption with intravaginal application is insignificant.

Indications:

Treatment of acute and chronic recurrent vaginal candidiasis: prevention of fungal infections of the vagina with reduced resistance of the body and against treatment with antibacterial agents and other drugs that disrupt the normal microflora of the vagina.

Contraindications:

Hypersensitivity to the components of the drug, pregnancy, lactation, children under 18 years.

Dosing and Administration:

Intravaginal. Preliminarily releasing the suppository from the contour pack, insert it deep into the vagina in the supine position on 1 suppository per day for 3-5 days depending on the course of the disease. In chronic candidiasis, 1 suppository is used for 10 days.

If there is no improvement after treatment or new symptoms appear, you should consult your doctor.

Side effects:

Hyperemia and irritation of the vaginal mucosa, itching of the vagina.

Allergic reactions: skin rash, hives.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Due to low absorption of the drug for intravaginal application in recommended (therapeutic) doses, an overdose is unlikely. If the drug is taken orally, poisoning symptoms may occur. There is no specific antidote. If necessary, take Activated carbon and conduct symptomatic treatment.

Interaction:

Because of low absorption for intravaginal application, interaction with other drugs is unlikely.

Special instructions:

Simultaneous treatment of the sexual partner is recommended to reduce the risk of recurrence of the disease.

In rare cases, penile hyperemia in the sexual partner is possible.

The use of suppositories can reduce the reliability of mechanical contraception (latex-containing condoms and vaginal diaphragms). During treatment it is recommended to select reliable methods of contraception.

During treatment it is necessary to control the picture of peripheral blood, the functional state of the liver and kidneys.

Vaginal suppositories under the action of body temperature are melted, forming a volumetric spreading foam mass, which promotes a uniform distribution of the active substance along the mucous membrane.

Read the instructions carefully before using the product.

Keep the manual, it may be needed again.

If you have any questions, contact your doctor.

The medicinal product that you are being treated is personally intended for you. and it should not be transferred to others, as it can harm them even if you have the same symptoms as you.

Effect on the ability to drive transp. cf. and fur:

The use of the drug does not affect the ability to drive vehicles, moving machinery and engage in potentially hazardous activities.

Form release / dosage:

Vaginal suppositories 400 mg.

Packaging:

5 suppositories per contour cell package.

For 1 or 2 contour mesh packages together with instructions for medical use in a pack of cardboard.

Storage conditions:

In a dry, dark place at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-000760

Date of registration:29.09.2011 / 27.04.2017

Expiration Date:Unlimited

The owner of the registration certificate:AVEKSIMA, JSC AVEKSIMA, JSC Russia

Manufacturer: & nbsp

FARMAPRIM, LLC The Republic of Moldova

Information update date: & nbsp02.01.2018

Illustrated instructions

Instructions

Ketoconazole (Ketoconazole)