Ketoconazole-Altpharm - instructions for use, dose, side effects, contraindications

Active substance - ketoconazole, an imidazole-dioxolane derivative. It has fungicidal and fungistatic action against dermatophytes (Trichophyton spp., Epidermophyton floccosum, Microsporum spp.) and yeast fungi (Pityrosporum spp., Candida spp., incl. Candida albicans). The mechanism of action is to inhibit the biosynthesis of ergosterol and change the lipid composition of the fungal membrane.

The drug is active against staphylococci and streptococci.

Indications:

Treatment of acute and chronic recurrent vaginal mycosis.

Prevention of the occurrence of fungal infections of the vagina with reduced resistance of the body and against treatment with antibacterial agents and other drugs that disrupt the normal microflora of the vagina.

Contraindications:

Hypersensitivity to the components of the drug, pregnancy, lactation.

Carefully:Children under 12 years of age (safety and efficacy not established).

Dosing and Administration:

The drug is used intravaginally, i.e. injected into the vagina.

To remove the suppository from the cell package, break one cell with the suppository on the notch and disconnect the edges of the tape, pull them in different directions. The suppository should be inserted into the vagina with a pointed end, whenever possible deeper.

For the prevention of fungal infections apply suppositories at a dose of 200 mg once a day for 10 days.

For treatment of thrush - Suppositories in a dose of 200 mg 2 times a day or suppositories at a dose of 400 mg once a day for 3 days.

With mycoses of genital organs, acute and chronic vaginal candidiasis - Suppositories in a dose of 200 mg 2 times a day or suppositories at a dose of 400 mg once a day for 5 days.

If necessary, you can combine the use of tablets (inside) and suppositories (intravaginally).

Side effects:

Local and allergic reactions are possible.

Local Reactions: flushing and irritation of the mucous membrane of the vagina, itching of the vagina; rarely - congestion and pain in the penis of a sexual partner.

Allergic reactions: skin rash, hives.

Interaction:

With simultaneous use with rifampicin and isoniazid, the concentration of ketoconazole in the plasma decreases.

When used simultaneously with cyclosporine, indirect anticoagulants and methylprednisolone ketoconazole can increase the concentration of the latter in the plasma.

Ethanol and other hepatotoxic drugs increase the risk of developing the hepatic parenchyma.

Increases the concentration of sulfonylurea derivatives and increases the risk of hypoglycemia.

Weaken the effect of amphotericin B.

Increases the concentration in the plasma of digoxin, midazolam and triazolam.

Increases the bioavailability of indinavir.

Reduces the stimulating effect of corticotropin on the adrenal glands.

When combined with terfenadine, astemizole and cisapride, increases the risk of severe ventricular tachycardia, incl. type "pirouette".

Increases the risk of bleeding "breakthrough" when using single-stage oral contraceptives with a low content of hormones.

Increases the toxicity of phenytoin.

Special instructions:

During treatment, it is necessary to regularly monitor the picture of peripheral blood, the functional state of the liver and kidneys.

Avoid contact with latex products (contraceptive diaphragms, condoms.

Form release / dosage:

Vaginal suppositories 200 mg, 400 mg.

Packaging:

For 5 pieces in a planar cell pack of a polyvinyl chloride film.

One contour pack together with instructions for use in a pack of cardboard.

Storage conditions:

In dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use the drug after the expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-004314/08

Date of registration:03.06.2008

Expiration Date:Unlimited

The owner of the registration certificate:ALTFARM, LLC ALTFARM, LLC Russia

Manufacturer: & nbsp

ALTFARM, LLC Russia

Representation: & nbspALTFARM LLC ALTFARM LLC Russia

Information update date: & nbsp02.01.2018

Illustrated instructions

Instructions

Ketoconazole-Altpharm (Ketoconazole-Altfarm)