The frequency of occurrence, side effects is characterized as often (≥ 1%), rarely (<1%).
The most common side effects: dizziness, headache, fatigue, diarrhea, dry cough, nausea.
From the cardiovascular system: often - marked decrease in blood pressure, orthostatic hypotension; rarely - chest pain, tachycardia, bradycardia, aggravation of symptoms of chronic heart failure, violation of atrioventricular conduction, myocardial infarction.
From the central nervous system: often - paresthesia, lability of mood, confusion, drowsiness, convulsive twitching of the muscles of the extremities and lips, rarely asthenic syndrome.
From the hematopoiesis: rarely - leukopenia, neutropenia, agranulocytosis, thrombocytopenia, with long-term treatment - anemia (reduction of hemoglobin, hematocrit, erythropenia).
From the respiratory system: rarely shortness of breath, bronchospasm.
From the digestive system: rarely dryness of the oral mucosa, anorexia, dyspepsia, taste changes, abdominal pain, pancreatitis, jaundice (hepatocellular or cholestatic), hepatitis.
From the skin: rarely - urticaria, pruritus, increased sweating, alopecia, photosensitivity.
From the genitourinary system: rarely - a violation of kidney function, oliguria, anuria, acute renal failure, uremia, proteinuria, decreased potency.
Laboratory indicators: often - hyperkalemia, hyponatremia; rarely - hyperbilirubinemia, increased activity of "hepatic" transaminases, hypercreatininaemia, increased concentrations of urea and creatinine.
Allergic reactions: rarely angioedema, swelling of the face, limbs, lips, tongue, epiglottis and / or larynx, skin rashes, itchy skin, fever, false positive antinuclear antibody test results, increased erythrocyte sedimentation rate (ESR), eosinophilia, leukocytosis.In rare cases, there is an intestinal angioedema.
Other: rarely - arthralgia / arthritis, vasculitis, myalgia.