The most common side effects: dizziness, headache (5-6% of patients), weakness, diarrhea, dry cough (3%), nausea, vomiting, orthostatic hypotension, skin rash, chest pain (1-3%).
Other side effects (frequency <1%):
From the immune system: (0.1%) angioedema (face, lips, tongue, larynx or epiglottis, upper and lower extremities).
From the cardiovascular system: a pronounced decrease in blood pressure, orthostatic hypotension, impaired renal function, heart rhythm disturbances, palpitations.
From the central nervous system: increased fatigue, drowsiness, convulsive twitching of the muscles of the extremities and lips.
On the part of the hematopoiesis system: possible leukopenia, neutropenia, agranulocytosis, thrombocytopenia, with long-term treatment - a small decrease in the concentration of hemoglobin and hematocrit, erythrocytopenia.
Laboratory indicators: hyperkalemia, azotemia, hyperuricemia, hyperbilirubinemia, increased activity of "hepatic" enzymes, especially in the presence of a history of kidney disease, diabetes and renosvascular hypertension.
Rarely occurring side effects (less than 1%):
From the cardiovascular system: a feeling of palpitations; tachycardia; myocardial infarction; cerebrovascular stroke in patients with an increased risk of the disease, due to a marked decrease in blood pressure.
From the digestive tract: dry mouth, anorexia, dyspepsia, changes in taste, abdominal pain, pancreatitis, hepatocellular or cholestatic jaundice, hepatitis.
From the skin: urticaria, increased sweating, itching, alopecia.
From the urinary system: renal dysfunction, oliguria, anuria, acute renal failure, uremia, proteinuria.
From the immune system: syndrome, which includes the acceleration of erythrocyte sedimentation rate (ESR), arthralgia, and the appearance of antinuclear antibodies.
From the central nervous system: asthenic syndrome, mood lability, confusion, decreased potency.
Other: myalgia, fever, impaired development of the fetus.