The incidence of side effects is characterized as often (≥1%), rarely (<1%).
Most often: dizziness, headache, fatigue, dry cough, nausea, diarrhea.
From the cardiovascular system: often marked decrease in blood pressure, orthostatic hypotension, rarely chest pain, tachycardia, bradycardia, aggravation of symptoms of chronic heart failure, violation of atrioventricular conduction, myocardial infarction.
From the central nervous system: often - paresthesia, lability of mood, confusion, drowsiness, convulsive twitching of the muscles of the limbs and lips, rarely - asthenic syndrome.
On the part of the hematopoiesis system: rarely - leukopenia, neutropenia, agranulocytosis, thrombocytopenia, with prolonged treatment - anemia (decrease in the concentration of hemoglobin, hematocrit, erythrocytopenia).
From the respiratory system: rarely shortness of breath, bronchospasm.
Laboratory indicators: often - hyperkalemia, hyponatremia, sometimes - hyperbilirubinemia, increased activity of "hepatic" enzymes, hypercreatininemia, increased urea and creatinine concentration in blood serum.
From the digestive system: rarely - dryness of the oral mucosa, dyspepsia, changes in taste, anorexia, abdominal pain, pancreatitis, hepatocellular case, cholestatic jaundice, hepatitis.
From the skin: rarely - urticaria, increased sweating, itching, alopecia, photosensitization.
From the genitourinary system: rarely - a violation of kidney function, oliguria, anuria, acute renal failure, uremia, proteinuria, decreased potency.
Allergic reactions: rarely angioedema, swelling of the face, extremities, lips, tongue, epiglottis and / or larynx, skin rashes, itching, fever, positive test results for antinuclear antibodies, increased erythrocyte sedimentation rate (ESR), eosinophilia, leukocytosis. In very rare cases - intestinal angioedema.
Other: rarely - myalgia, arthralgia / arthritis, vasculitis.