According to the World Health Organization (WHO), adverse reactions are classified according to their developmental frequency as follows: very often (≥ 1/10), often (≥1 / 100, <1/10), infrequently (≥1 / 1000, < 1/100), rarely (≥1 / 10000, <1/1000) and very rarely (<1/10000); frequency is unknown - according to available data, it was not possible to establish the frequency of occurrence.
From the immune system: rarely: hypersensitivity, anaphylactic shock (including anaphylactic shock).
From the nervous system: often: headache, dizziness; infrequently: drowsiness; rarely: loss of consciousness, stupor, depressed level of consciousness, hypertension, impaired coordination.
From the sense organs: rarely: miosis.
From the digestive system: often: constipation, flatulence, nausea; infrequently: pain or discomfort in the abdomen, dry mouth, vomiting, indigestion, indigestion; rarely: intestinal obstruction, megacolon, glossalgia, bloating.
From the urinary system: rarely: retention of urination.
From the skin and subcutaneous tissues: infrequently: rashes on the skin; rarely: Bullous rash (including erythema multiforme, toxic epidermal necrolysis and Stevens-Johnson syndrome), angioedema, urticaria, skin itching.
Other: rarely: fatigue.