Loperamide - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Loperamide, binding to opioid receptors of the intestinal wall (stimulation of cholinergic and adrenergic neurons through guanine nucleotides), reduces tone and motility of the smooth muscles of the intestine, slows the passage of the contents of the intestine, reduces the secretion of fluid and electrolytes with feces. Increases the tone of the anal sphincter, promotes retention of fecal masses and reduced urge to defecate. The action comes quickly and lasts 4-6 hours.

Pharmacokinetics:

Absorption - 40%. The connection with plasma proteins is 97%. The half-life is 9-14 hours. Does not penetrate blood-brain barrier. Getting into the systemic bloodstream, almost completely metabolized in the liver by conjugation.It is excreted mainly with bile, an insignificant part of the kidneys (in the form of conjugated metabolites).

Indications:

Symptomatic treatment of acute and chronic diarrhea of various genesis (allergic, emotional, drug, radiation, with a change in diet and quality of food, in violation of metabolism and absorption, as an auxiliary for diarrhea of infectious genesis).

Regulation of stool in patients with ileostomy.

Contraindications:

Hypersensitivity to the drug, diverticulosis, intestinal obstruction, ulcerative colitis in the acute stage, diarrhea on the background of acute pseudomembranous enterocolitis, in the form of monotherapy - dysentery and other infections of the gastrointestinal tract; pregnancy (I trimester), lactation period, loperamide in tablets are not prescribed for children under 6 years.

Carefully:

Liver failure.

Dosing and Administration:

Inside. Adults with acute and chronic diarrhea initially assigned 2 tablets (4 mg), then 1 tablet (2 mg) after each act of defecation in the case of a loose stool. The maximum daily dose is 8 tablets (16 mg).

Children over 6 years of age are prescribed 1 tablet (2 mg) after each act of defecation in the case of a loose stool. The maximum daily dose is 3 tablets (6 mg).

After normalization of the stool or in the absence of stool for more than 12 hours, treatment with loperamide should be discontinued.

Side effects:

Discomfort in the abdomen, flatulence, gastralgia, dry mouth, allergic reactions (skin rash), intestinal colic, nausea, vomiting, constipation, headache, drowsiness or insomnia, dizziness. Rarely, urine retention. Very rarely - intestinal obstruction.

Overdose:

Symptoms: oppression of the central nervous system (stupor, impaired coordination, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.

Treatment: antidote - naloxone; Considering that the duration of action of loperamide is greater than that of naloxone, it is possible to re-introduce the latter.

Symptomatic treatment: Activated carbon, gastric lavage, artificial ventilation.

Medical surveillance is necessary for at least 48 hours.

Special instructions:

If there is no effect after 2 days of loperamide use, it is necessary to clarify the diagnosis and exclude the infectious genesis of diarrhea.

Effect on the ability to drive transp. cf. and fur:

During the treatment period, care must be taken when driving vehicles and taking other potentially dangerous species activities that require increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Tablets 2 mg.

Packaging:

10 tablets per contour cell pack. For 1 or 2 contour packs with instructions for use in a pack of cardboard.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-004065/09

Date of registration:25.05.2009

Expiration Date:Unlimited

The owner of the registration certificate:BIOKOM, CJSC BIOKOM, CJSC Russia

Manufacturer: & nbsp

BIOKOM, CJSC Russia

Information update date: & nbsp02.04.2018

Illustrated instructions

Instructions

Loperamide (Loperamide)