Loperamide - instructions for use, dose, side effects, contraindications

Excipients: lactose monohydrate (sugar milk) - 106.0 mg, corn starch - 26.0 mg, magnesium stearate - 1.0 mg, povidone (polyvinylpyrrolidone) -5.0 mg.

Description:

Tablets from white to white with a yellowish hue of color, flat-cylindrical shape, with a facet on both sides and risk from one side.

Pharmacotherapeutic group:Antidiarrhoeic remedy

ATX: & nbsp

A.07.D.A Drugs that reduce the peristalsis of the digestive tract

A.07.D.A.03 Loperamide

Pharmacodynamics:

Reduces the tone and motility of the smooth muscles of the intestine, slows the passage of the contents of the intestine, reduces the secretion of fluid and electrolytes with feces. Increases the tone of the anal sphincter. The action comes quickly and lasts 4-6 hours.

Pharmacokinetics:

Absorption - 40%. The connection with plasma proteins is 97%. The half-life is 9-14 hours. It does not penetrate the blood-brain barrier. It is almost completely metabolized in the liver by conjugation. It is excreted mainly with bile and kidneys.

Indications:

Symptomatic treatment of acute and chronic diarrhea of various genesis (allergic, emotional, drug, radiation, with a change in diet and qualitative composition of food,at disturbance of a metabolism and an absorption; As an adjuvant for diarrhea of infectious genesis).

Regulation of stool in patients with ileostomy.

Contraindications:

Hypersensitivity to the drug, diverticulosis, intestinal obstruction, ulcerative colitis in the acute stage, diarrhea on the background of acute pseudomembranous enterocolitis, dysentery and other infections of the gastrointestinal tract; pregnancy (I trimester), lactation period, loperamide in tablets are not prescribed for children under 6 years.

Carefully:

Liver failure.

Dosing and Administration:

Inside. Adults with acute and chronic diarrhea are initially assigned 2 tablets (0.004 g), then 1 tablet (0.002 g) after each act of defecation in the case of a loose stool. The maximum daily dose is 8 tablets (0.016 g).

Children over 6 years of age are prescribed 1 tablet (0.002 g) after each act of defecation in the case of a loose stool. The maximum daily dose is 3 tablets (0.006 g).

After normalization of the stool or in the absence of stool for more than 12 hours, treatment with Loperamide should be discontinued.

Side effects:

Headache, gastralgia, dry mouth, allergic reactions (skin rash), drowsiness or insomnia, dizziness, intestinal colic, nausea, vomiting, constipation. Rarely, urine retention. Very rarely - intestinal obstruction.

Overdose:

Symptoms: depression of the central nervous system (stupor, impaired coordination, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.

Treatment: antidote - naloxone; Considering that the duration of action of loperamide is greater than that of naloxone, it is possible to re-introduce the latter. Symptomatic treatment: Activated carbon, gastric lavage, artificial ventilation. Medical surveillance is necessary for at least 48 hours.

Special instructions:

If there is no effect after 2 days of Loperamide use, it is necessary to clarify the diagnosis and exclude the infectious genesis of diarrhea. If the treatment develop constipation or bloating, loperamide should be canceled. In patients with impaired liver function, careful monitoring of signs of toxic damage to the central nervous system is necessary. During the treatment of diarrhea, it is necessary to replenish the loss of fluid and electrolytes.

Effect on the ability to drive transp. cf. and fur:

During the treatment period, care must be taken when driving vehicles and practicing other potentially hazardous activities,requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Tablets 2 mg.

Packaging:

For 10, 20, 25, 30 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

By 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 tablets in cans of polymeric for medicines.

One jar or 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 contour mesh packages together with the instruction for use are placed in a cardboard package (pack) made of cardboard.

Storage conditions:Store in a dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N002105 / 01

Date of registration:17.07.2008 / 09.07.2014

Expiration Date:Unlimited

The owner of the registration certificate:OZONE, LLC OZONE, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp02.04.2018

Illustrated instructions

Instructions

Loperamide (Loperamide)