Loperamide - instructions for use, dose, side effects, contraindications

Excipients: lactose monohydrate 100 mg, corn starch 30 mg, magnesium stearate 1.36 mg, stearic acid 2.64 mg, povidone (low molecular weight polyvinylpyrrolidone medical) 4 mg.

Description:Tablets from white to white with a yellowish hue of color, flat-cylindrical with a facet on both sides.

Pharmacotherapeutic group:Antidiarrhoeic remedy

ATX: & nbsp

A.07.D.A Drugs that reduce the peristalsis of the digestive tract

A.07.D.A.03 Loperamide

Pharmacodynamics:Loperamide, communicating with the opioid receptors of the intestinal wall, reduces the tone and motility of the smooth muscles of the intestine. Slows down the passage of the contents of the intestine, reduces the secretion of fluid and electrolytes with feces. Increases the tone of the anal sphincter. The action comes quickly and lasts 4-6 hours.

Pharmacokinetics:Absorption - 40%. The connection with plasma proteins is 97%. The half-life is 9-14 hours. It does not penetrate the blood-brain barrier. It is almost completely metabolized by the liver by conjugation. It is excreted mainly with bile, an insignificant part is excreted by the kidneys (in the form of conjugated metabolites).

Indications:Symptomatic treatment of acute and chronic diarrhea of various genesis (allergic,emotional, medicinal, radiation; when changing the diet and quality of food, in violation of metabolism and absorption; as an aid for diarrhea of infectious genesis). Regulation of stool in patients with ileostomy.

Contraindications:Hypersensitivity to the drug, diverticulosis, intestinal obstruction, ulcerative colitis in the acute stage, diarrhea on the background of pseudomembranous enterocolitis, in the form of monotherapy - dysentery and other infections of the gastrointestinal tract, pregnancy (I trimester), lactation period, loperamide in tablets are not prescribed for children under 6 years.

Carefully:With caution should apply the drug to people with hepatic insufficiency.

Dosing and Administration:

Inside. Adults with acute and chronic diarrhea initially assigned 2 tablets (4 mg), then 1 tablet (2 mg) after each act of defecation in the case of a loose stool. The maximum daily dose is 8 tablets (16 mg).

Children over 6 years of age are prescribed 1 tablet (2 mg) after each act of defecation in the case of a loose stool. The maximum daily dose is 3 tablets (6 mg).

After normalization of the stool or in the absence of stool for more than 12 hours, the drug should be discontinued.

Side effects:Allergic reactions (skin rash), drowsiness, dizziness, hypovolemia, electrolyte disorders, dry mouth, gastralgia, abdominal discomfort, nausea, vomiting, constipation, flatulence. Rarely, urine retention. Very rarely - intestinal obstruction.

Overdose:

Symptoms: depression of the central nervous system (stupor, impaired coordination, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.

Treatment: antidote - naloxone; Considering that the duration of action of loperamide is greater than that of naloxone, it is possible to re-introduce the latter. Symptomatic treatment, Activated carbon, gastric lavage, artificial ventilation. Medical surveillance is necessary for at least 48 hours.

Interaction:It is undesirable to prescribe the drug together with atropine and other anticholinergic drugs in order to avoid amplification of their effect.

Special instructions:

In the absence of effect after 2 days of drug use, it is necessary to clarify the diagnosis and exclude the infectious genesis of diarrhea. If the treatment develops constipation or bloating, the drug should be discarded.In patients with impaired liver function, careful monitoring of signs of toxic damage to the central nervous system is necessary ..

During the treatment of diarrhea, it is necessary to replenish the loss of fluid and electrolytes.

Effect on the ability to drive transp. cf. and fur:During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

Form release / dosage:Tablets of 2 mg.

Packaging:For 10 tablets in a planar cell pack of a polyvinyl chloride film. For 1 or 2 contour packs with instructions for use in a pack of cardboard.

Storage conditions:In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

5 years.

Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:П N014424 / 01

Date of registration:19.11.2007

Expiration Date:Unlimited

The owner of the registration certificate:LEKHIM-KHARKOV, CJSC LEKHIM-KHARKOV, CJSC Ukraine

Manufacturer: & nbsp

LEKHIM-KHARKOV, CJSC Ukraine

Representation: & nbspAlfa Grand TD, LLCAlfa Grand TD, LLCRussia

Information update date: & nbsp02.04.2018

Illustrated instructions

Instructions

Loperamide (Loperamide)