Active substanceMagnesium sulfateMagnesium sulfate
Similar drugsTo uncover
  • Kormagnezin®
    solution in / in 
  • Magnesium sulfate
    solution in / in 
    GROTEKS, LLC     Russia
  • Magnesium sulfate
    powder inwards 
  • Magnesium sulfate
    solution in / in 
  • Magnesium sulfate
    solution in / in 
  • Magnesium sulfate
    powder inwards 
  • Magnesium sulfate
    solution in / in 
    ATOLL, LLC     Russia
  • Magnesium sulfate
    solution in / in 
  • Magnesium sulfate
    solution w / m in / in 
  • Magnesium sulfate
    solution in / in 
  • Magnesium sulfate
    solution w / m in / in 
  • Magnesium sulfate
    solution in / in 
    Company DEKO, LLC     Russia
  • Magnesium sulfate
    powder inwards 
  • Magnesium sulfate
    solution in / in 
    DALHIMFARM, OJSC     Russia
  • Magnesium sulfate
    solution in / in 
  • Magnesium sulfate
    solution in / in 
  • Magnesium sulfate
    solution in / in 
    ESKOM NPK, OAO     Russia
  • Magnesium sulfate
    powder inwards 
  • Magnesium sulfate
    solution in / in 
    BIOSINTEZ, PAO     Russia
  • Magnesium sulfate
    powder inwards 
  • Magnesium sulfate
    solution in / in 
    Mapichem AG     Switzerland
  • Magnesium sulfate
    powder inwards 
    YUZHFARM, LLC     Russia
  • Magnesium sulfate
    solution in / in 
    SYNTHESIS, OJSC     Russia
  • Magnesium sulfate-Darnitsa
    solution in / in 
  • Dosage form: & nbsp

    Powder for solution for oral administration

    Composition:

    Magnesium sulfate heptahydrate-10 g, 20 g or 25 g.

    Description:Colorless prismatic crystals that weathered in the air.
    Pharmacotherapeutic group:Laxative
    ATX: & nbsp

    A.12.C.C   Preparations of magnesium

    Pharmacodynamics:

    When ingestion acts as a laxative (due to poor absorption of the drug in the intestine it creates a high osmotic pressure, there is accumulation of water in the intestine, the contents of the intestine liquefy, the peristalsis intensifies). Has choleretic effect. It is an antidote for poisoning with salts of heavy metals.

    Pharmacokinetics:

    When taken orally, poorly absorbed (no more than 20%) in the jejunum and ileum, is reabsorbed from bile, pancreatic and intestinal juice.In the syndrome of malabsorption and the consumption of foods rich in fats, the absorption of magnesium ions decreases. The connection with intracellular proteins and macroergic phosphates is 30%. Time of the maximum concentration in the blood plasma - 4 hours. Magnesium ions are deposited in bones, skeletal musculature, kidneys, liver and myocardium; in small amounts in the tissue fluid and red blood cells. Penetrates through the blood-brain and placental barrier, creates in the mother's milk concentrations that are twice as high as those in the plasma. Excretion is performed by the kidneys and with feces.

    Indications:

    Constipation, cleansing of the intestine before the diagnostic manipulation.

    Poisoning with salts of heavy metals (mercury, arsenic, tetraethyl lead, barium).

    Contraindications:

    Hypersensitivity, appendicitis, rectal bleeding, intestinal obstruction, acute inflammatory diseases of the gastrointestinal tract, dehydration, hypermagnesia, pregnancy, the period of breastfeeding.

    Carefully:

    Blockade of the heart, myocardial damage, chronic renal failure.

    Pregnancy and lactation:It is not recommended to take during pregnancy and lactation.
    Dosing and Administration:

    Is taken internally.

    Adults - 20-25 g once a day on an empty stomach, previously dissolving the drug in a glass of water (200 ml).

    Children over 12 years - 10 grams 1 time per day (for 1/2 cup water).

    Children aged 6-12 years are prescribed from 5 to 10 grams (that is, from half to the whole volume of the solution, prepared at the rate of 10 g per 1/2 cup of water).

    In children up to 6 years of age, the drug can be used only as directed by a doctor.

    Daily doses in children are determined from the calculation of 1 g for 1 year of life.

    Possible use of the drug in the form of enemas (50-100 ml 20-30 % solution).

    When poisoning with salts of heavy metals, wash the stomach with 1% magnesium sulfate solution or give inside 20 g, dissolved in a glass of water (200 ml).

    Side effects:

    Nausea, vomiting, diarrhea, exacerbation of inflammatory diseases of the gastrointestinal tract, flatulence, abdominal pain of a spastic nature, thirst, electrolyte imbalance (fatigue, asthenia, confused consciousness, arrhythmia, seizures), hypermagnesia in the presence of renal failure (early signs of hypermagnesia: bradycardia, diplopia, sudden "tide" of blood to the skin of the face, headache, dizziness, lowering blood pressure, nausea, shortness of breath, blurred speech, vomiting, weakness).

    Overdose:

    Symptoms: severe diarrhea.

    Treatment - symptomatic.

    Interaction:

    Reduces the effect of oral anticoagulants (including derivatives of coumarin or indandione derivatives), cardiac glycosides, phenothiazines (especially chlorpromazine). Reduces the absorption of ciprofloxacin etidronovoy acid, tetracycline antibiotics (unabsorbed forms complexes with oral tetracyclines), reduces the effect of streptomycin and tobramycin (laxatives magnesium containing medicines should be taken within 1 -2 hours after the application of the above drugs).

    Pharmaceutically compatible (precipitate formed), calcium preparations, ethanol (in high concentrations), carbonates, bicarbonates and phosphates of alkali metals, salts of arsenic acid, barium, strontium, clindamycin phosphate, hydrocortisone sodium succinate, polymyxin B sulfate, procaine hydrochloride, salicylates and tartrates .

    Special instructions:The drug should be taken occasionally, systematic use is not recommended.
    Form release / dosage:

    Powder for solution for oral administration.

    Packaging:

    By 10 g, 20 g or 25 g in heat-sealing bags of packaging material from the combined materials.

    Packages are placed in a group package together with an equal number of instructions for use.

    Storage conditions:

    In a dry, protected from light place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    5 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-001628
    Date of registration:06.04.2012
    Expiration Date:Unlimited
    The owner of the registration certificate:TULA PHARMACEUTICAL FACTORY, LTD. TULA PHARMACEUTICAL FACTORY, LTD. Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.03.2018
    Illustrated instructions
      Instructions
      Up