Magnesium sulfate - instructions for use, dose, side effects, contraindications

When ingestion acts as a laxative (in connection with the poor absorption of the drug in the intestine it creates a high osmotic pressure, there is an accumulation of water in the intestine, the contents of the intestine liquefy, the peristalsis intensifies). Has choleretic effect. It is an antidote for poisoning with salts of heavy metals (it forms insoluble sulfate complexes of heavy metals and, through laxative action, removes them from the body).

Pharmacokinetics:

When taken orally, poorly absorbed (no more than 20%) in the jejunum and ileum, is reabsorbed from bile, pancreatic and intestinal juice. In the syndrome of malabsorption and the consumption of foods rich in fats, the absorption of magnesium ions decreases. The connection with intracellular proteins and macroergic phosphates is 30%. Time of the maximum concentration in the blood plasma - 4 hours. Magnesium ions are deposited in bones, skeletal musculature, kidneys, liver and myocardium; in small amounts in the tissue fluid and red blood cells. It penetrates the blood-brain and placental barriers created by the concentration in breast milk, twice exceeding those of plasma. Excretion is performed by the kidneys and with feces.

Indications:

Constipation, cleansing of the intestine before the diagnostic manipulations.

Poisoning with salts of heavy metals (mercury, arsenic, tetraethyl lead, barium).

Contraindications:

Hypersensitivity, appendicitis, rectal bleeding, intestinal obstruction, acute inflammatory diseases of the gastrointestinal tract, dehydration, gipermagniemiya, pregnancy, breastfeeding, children under 18 years.

Carefully:

Blockade of the heart, heart failure, chronic renal failure.

Dosing and Administration:

Is taken internally.

Adults - 20-25 g once a day on an empty stomach, previously dissolving the drug in a glass of water (200 ml).

It is possible to use the drug in the form of enemas (50-100 ml of 20-30% solution).

When poisoning with salts of heavy metals, wash the stomach with 1% magnesium sulfate solution or give inside 20 g, dissolved in a glass of water (200 ml). To rinse the stomach, the patient is given a drink of 1% a solution of magnesium sulfate (20 g per 2 liters of water). If vomiting does not occur quickly, then it is caused by mechanical action on the root of the tongue. Rinsing is carried out to clear washings.

Side effects:

Nausea, vomiting, diarrhea, exacerbation of inflammatory diseases of the gastrointestinal tract, flatulence, pain in the abdomen of a spastic nature, thirst, electrolyte balance disorder (fatigue, asthenia, confused consciousness, arrhythmia, seizures), hypermagnesia in the presence of renal failure (early signs of hypermagnesemia : bradycardia, diplopia, sudden "tide" of blood to the skin of the face, headache, dizziness, lowering blood pressure, nausea, shortness of breath, lubricated speech, vomiting, weakness).

In case of occurrence of the above-listed adverse reactions or adverse reactions not indicated in this manual for medical use of the drug, you should consult a doctor.

Overdose:

Symptoms: severe diarrhea.

If you suspect an overdose, you should see a doctor.

Treatment: symptomatic. As an antidote, intravenously (slowly) calcium preparations (calcium chloride and calcium gluconate), peritoneal dyad or hemodialysis, symptomatic agents (corrective functions of the cardiovascular system).

Interaction:

Reduces the effect of oral anticoagulants (including coumarin derivatives or derivatives of indanedione), cardiac glycosides, phenothiazines, (especially chlorpromazine).

Reduces the absorption of ciprofloxacin, etidronic acid, antibiotics of the tetracycline group (forms unabsorbed complexes with oral tetracyclines), weakens the effect of streptomycin and tobramycin (laxative magnesium-containing drugs, should be taken 1-2 hours after the application of the above medicines).

Pharmaceutically compatible (precipitate formed), calcium preparations, ethanol (in high concentrations), carbonates, bicarbonates and phosphates of alkali metals, salts of arsenic acid, barium, strontium, clindamycin phosphate, hydrocortisone sodium succinate, polymyxin B sulfate, procaine hydrochloride, salicylates and tartrates .

Special instructions:

The drug should be taken occasionally (not regularly, in the case of situations indicated in the section "Indications for Use"), systematic use is not recommended. If you do not have a bowel movement after taking the medication, you should consult your doctor.

With cardiac and renal insufficiency, eating disorders (anorexia or bulimia), if you take a laxative during the week, you should consult your doctor.

Effect on the ability to drive transp. cf. and fur:

During the treatment period, patients should refrain from driving and other potentially hazardous activities requiring increased attention and speed of psychomotor reactions (risk of diplopia, dizziness, headache).

Form release / dosage:

Powder for solution for oral administration.

Packaging:

By 20, 25 and 50 g in bags heat-sealing from paper with a polymer-coated packaging or polyethylene coating, or from a material of a combined "Bufleen" type, or into bags of a polyethylene terephthalate film.

1, 2, 3, 4, 6, 8, 10 and 20 heat-seal bags are placed together with the instruction for use in a pack of cardboard box or in bags of wrapping paper.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use after the date shown on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-003463

Date of registration:16.02.2016

Expiration Date:16.02.2021

The owner of the registration certificate:YUZHFARM, LLC YUZHFARM, LLC Russia

Manufacturer: & nbsp

YUZHFARM, LLC Russia

Representation: & nbspYUZHFARM, LLCYUZHFARM, LLC

Information update date: & nbsp25.03.2018

Illustrated instructions

Instructions

Magnesium sulfate (Magnesium sulfate)