Magnesium sulfate - instructions for use, dose, side effects, contraindications

Pharmacodynamics:When ingested, it has a laxative effect. In connection with poor absorption of the drug in the intestine, a high osmotic pressure is created, water accumulates, the contents of the intestine dilute, and the peristalsis intensifies. Has choleretic effect. It is an antidote for poisoning with salts of heavy metals.

Pharmacokinetics:

When taken orally, poorly absorbed (no more than 20%) in the jejunum and ileum, is reabsorbed from the bile,pancreatic and intestinal juice. With the syndrome of malabsorption and eating foods rich in fats, the absorption of magnesium ions decreases. The connection with intracellular proteins and macroergic phosphates is 30%. Time of the maximum concentration in the blood plasma - 4 hours. Magnesium ions are deposited in bones, skeletal musculature, kidneys, liver and myocardium; in small amounts in the tissue fluid and red blood cells. Penetrates through the blood-brain and placental barrier, creates in the mother's milk concentrations that are twice as high as those in the plasma.

Excretion is performed by the kidneys and with feces.

Indications:Constipation, cleansing of the intestine before the diagnostic manipulation. Poisoning with salts of heavy metals (mercury, arsenic, tetraethyl lead, barium).

Contraindications:Increased individual sensitivity, rectal bleeding, intestinal obstruction, acute inflammatory diseases of the gastrointestinal tract, dehydration, severe renal failure, hypermagnesia.

Dosing and Administration:

As a laxative taken inside at night or half an hour before meals,dissolving the contents of the packet (20 g) in 1/2 cup warm water (100 ml); children are prescribed at a rate of 1 g for 1 year of life.

It is possible to use the drug in the form of enemas (100 ml of 20% -30% solution).

When poisoning with salts of heavy metals, wash the stomach with 1% magnesium sulfate solution or give inside 20 g, dissolved in a glass of water (200 ml).

Side effects:Nausea, vomiting, diarrhea, exacerbation of inflammatory diseases of the gastrointestinal tract, flatulence, abdominal pain of a spastic nature, thirst, electrolyte imbalance (fatigue, asthenia, confused consciousness, arrhythmia, seizures), hypermagnesia in the presence of renal failure (early signs of hypermagnesia: bradycardia, diplopia, sudden "tide" of blood to the skin of the face, headache, dizziness, lowering blood pressure, nausea, shortness of breath, blurred speech, vomiting, weakness).

Overdose:

Symptoms: severe diarrhea.

Treatment - symptomatic.

Interaction:

Reduces the effect of oral anticoagulants (including coumarin derivatives or derivatives of indanediol), cardiac glycosides, phenothiazines, (especially chlorproxyazine).

Reduces the absorption of ciprofloxacin, etidronic acid, antibiotics of the tetracycline group, weakens the effects of streptomycin and tobramycin (laxatives containing magnesium should be taken 1-2 hours after the application of the above drugs).

Pharmaceutically compatible (precipitate formed), calcium preparations, ethanol (in high concentrations), carbonates, bicarbonates and phosphates of alkali metals, salts of arsenic acid, barium, strontium, clindamycin phosphate, hydrocortisone sodium succinate, polymyxin B sulfate, procaine hydrochloride, salicylates and tartrates .

Special instructions:

Magnesium sulfate should be taken only in dissolved form!

The drug should be taken occasionally, systematic use is not recommended.

Form release / dosage:Powder for solution for oral administration.

Packaging:For 20 g in heat-sealed bags. Packages, together with an equal number of instructions for use, are placed in a group package.

Storage conditions:

At a temperature not exceeding 20 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N000365 / 01

Date of registration:18.07.2008 / 21.06.2010

Expiration Date:Unlimited

The owner of the registration certificate:MOSCOW PHARMACEUTICAL FACTORY, CJSC MOSCOW PHARMACEUTICAL FACTORY, CJSC Russia

Manufacturer: & nbsp

MOSCOW PHARMACEUTICAL FACTORY, CJSC Russia

Information update date: & nbsp24.03.2018

Illustrated instructions

Instructions

Magnesium sulfate (Magnesium sulfate)