Magnesium sulfate - instructions for use, dose, side effects, contraindications

Pharmacodynamics:When ingested, it has a laxative effect. In connection with poor absorption of the drug in the intestine, a high osmotic pressure is created, water accumulates, the contents of the intestine dilute, and the peristalsis intensifies. Has choleretic effect. It is an antidote for poisoning with salts of heavy metals.

Pharmacokinetics:When taken orally, poorly absorbed (no more than 20%) in the jejunum and ileum, is reabsorbed from bile, pancreatic and intestinal juice. In the syndrome of malabsorption and the consumption of foods rich in fats, the absorption of magnesium ions decreases. The connection with intracellular proteins and macroergic phosphates is 30%. Time of the maximum concentration in the blood plasma - 4 hours. Magnesium ions are deposited in bones, skeletal musculature, kidneys, liver and myocardium; in small amounts in the tissue fluid and red blood cells. Penetrates through the blood-brain and placental barrier, creates in the mother's milk concentrations that are twice as high as those in the plasma. Excretion is performed by the kidneys and with feces.

Indications:Constipation, cleansing of the intestine before the diagnostic manipulation. Poisoning with salts of heavy metals (mercury, arsenic, tetraethyl lead, barium).

Contraindications:Increased individual sensitivity, rectal bleeding, intestinal obstruction, acute inflammatory diseases of the gastrointestinal tract, dehydration, severe renal failure, hypermagnesia.

Carefully:

Blockade of the heart, myocardial damage.

Dosing and Administration:

Is taken internally.

Adults - 15-25 g once a day on an empty stomach, previously dissolving the drug in a glass of water (200 ml).

Children over 12 years old - 10 grams 1 time per day (for 1/2 cup water).

Children aged 6-12 years are designated from 5 to 10 g (i.e., from half to the whole volume of the solution, prepared from 10 g per 1/2 cup water).

In children up to 6 years of age, the drug can be used only as directed by a doctor.

Daily doses are determined from the calculation of 1 g for 1 year of life.

It is possible to use the drug in the form of enemas (50-100 ml of 20-30% solution).

When poisoning with salts of heavy metals, wash the stomach with 1% magnesium sulfate solution or give inside 20 g, dissolved in a glass of water (200 ml).

Side effects:Nausea, vomiting, diarrhea, exacerbation of inflammatory diseases of the gastrointestinal tract, bloating, abdominal pain, spastic nature, thirst, electrolyte imbalance (fatigue, asthenia, confusion, arrhythmia, seizures), gipermagniemiya in the presence of renal failure (early signs hypermagnesemia: bradycardia, double vision, a sudden "tide" of blood to the face, headache, dizziness, - decrease in blood pressure, nausea, shortness of breath, slurred speech, vomiting, weakness).

Overdose:

Symptoms: severe diarrhea.

Treatment: symptomatic.

Interaction:

Reduces the effect of oral anticoagulants (including coumarin derivatives or derivatives of indanediol), cardiac glycosides, phenothiazines, (especially chlorpromazine). Reduces the absorption of ciproflbkeacin, etidronic acid, antibiotics of the tetracycline group, weakens the effects of streptomycin and tobramycin (laxatives containing magnesium should be taken 1-2 hours after the application of the above drugs).

Pharmaceutically incompatible with sediments of calcium, ethanol (in high concentrations), carbonates, hydrogen carbonates and phosphates of alkali metals, arsenic acid, barium, strontium, clindamycin, hydrocortisone, polymyxin B, procaine, salicylates and tartrates.

Special instructions:

Magnesium sulfate should be taken only in dissolved form!

The drug should be taken occasionally, systematic use is not recommended.

Form release / dosage:Powder for solution for oral administration.

Packaging:

For 10 g, 20 g and 25 g in packages, heat-sealable; 20 g, 25 g and 50 g in cans of glass and polymer cans.Heat-sealable bags of 10 g are placed on 5, 10, 20, 30, 40 or 50 pieces together with instructions for use in a pack of cardboard. Heat-sealed bags of 20 g and 25 g are placed on 5, 10 or 20 pieces together with instructions for use in a pack of cardboard.

Banks and heat-sealing bags without a bundle are packed in a group container with an enclosure of instructions for use in an amount equal to the number of primary packages (cans or / packages).

Storage conditions:

In a well ukuporennoy packaging at a temperature of no higher than 25 ° C.

In a place inaccessible to children.

Shelf life:

5 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N001466 / 01

Date of registration:29.08.2008

Expiration Date:Unlimited

Date of cancellation:2018-04-02

The owner of the registration certificate:PHARMACEUTICAL FACTORY of St. Petersburg, JSC PHARMACEUTICAL FACTORY of St. Petersburg, JSC Russia

Manufacturer: & nbsp

Pharmaceutical factory of St. Petersburg, JSC Russia

Information update date: & nbsp02.04.2018

Illustrated instructions

Instructions

Magnesium sulfate (Magnesium sulfate)